Applied Sciences,
Год журнала:
2023,
Номер
13(7), С. 4095 - 4095
Опубликована: Март 23, 2023
The
C-3
functionalization
of
1H-indazole
could
produce
a
lot
highly
valuable
pharmaceutical
precursors,
which
be
used
for
the
treatment
cancer
and
many
other
inflammatory
diseases.
This
work
was
focused
on
through
Suzuki–Miyaura
cross-coupling
3-iodo-1H-indazole
with
organoboronic
acids,
catalyzed
by
various
palladium
catalysts
immobilized
over
imidazolium
ionic
liquids,
as
well
catalyst
recycling.
A
series
reaction
parameters,
including
substrate,
catalyst,
liquid,
were
fully
investigated.
It
is
significant
to
note
that
yields
present
mainly
determined
solvent
used,
more
than
chemical
structure
substrate.
Furthermore,
ferrocene-based
divalent
complexes
showed
better
catalytic
outputs
compared
simple
salts.
Moreover,
using
two
BMImX
(BMIm+
=
1-n-butyl-3-methylimidazolium,
X−
BF4−,
PF6−)
not
only
improved
cross-coupled
products,
but
also
avoided
formation
Pd(0)
black,
non-ionic
liquid
facilitated
reactions,
simultaneously
making
recycling
effective.
On
average,
BMImBF4
performed
BMImPF6.
Additionally,
scientific
calculations
revealed
1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride
dichloromethane
complex
(PdCl2(dppf))
lower
energy
barrier
in
intermediates
[1,1′-bis(di-tert-butylphosphino)ferrocene]dichloropalladium(II)
(PdCl2(dtbpf)),
leading
higher
outputs.
may
contribute
development
1H-indazole-derived
new
pharmaceuticals.
Green Chemistry,
Год журнала:
2023,
Номер
25(21), С. 8459 - 8493
Опубликована: Янв. 1, 2023
This
review
comprehensively
summarizes
visible
light-induced
difunctionalization
strategies
for
alkene
and
alkyne
systems
in
metal-free
conditions
with
literature
coverage
up
to
July
2023.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(8), С. 1591 - 1628
Опубликована: Янв. 1, 2023
Photoredox
catalysis
has
demonstrated
rapid
evolution
in
the
field
of
synthetic
organic
chemistry.
On
other
hand,
splendour
cascade
reactions
providing
complex
molecular
architectures
renders
them
a
cutting-edge
research
area.
Therefore,
merging
photocatalysis
with
synthesis
brings
out
paradigm
immense
potential.
The
development
photocascade
for
target
molecule
particular
skeleton
and
stereochemical
framework
presents
certain
challenges
but
provides
robust
environmentally
benign
alternative.
This
comprehensive
review
assembles
all
accomplishments
highlights
visible-light-induced
literature
coverage
up
to
October
2022.
ACS Catalysis,
Год журнала:
2024,
Номер
14(2), С. 1193 - 1204
Опубликована: Янв. 9, 2024
Herein,
the
C3–H
alkylation
of
2H-indazoles
and
indoles
with
sulfoxonium
ylides
is
developed
under
visible-light
photocatalysis.
This
protocol
employs
easily
accessible
reagents,
a
wide
range
2H-indazoles,
indoles,
are
suitable
for
this
reaction
to
afford
desired
products
benign
conditions.
Synergistic
experimental
computational
studies
suggest
that
involving
photocatalysis
could
proceed
via
different
mechanistic
pathways.
For
C3-alkylation
triplet
energy
transfer
pathway
proposed
quenching
excited
photocatalyst.
Subsequently,
formed
state
undergo
radical
attack
on
C═S
moiety
ylides.
After
dissociation
DMSO
1,2-H
migration,
final
product
be
yielded.
However,
such
not
applicable
indoles.
Instead,
converted
C-centered
in
presence
KH2PO4
photoredox
The
can
C3-site
thus
lead
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2186 - 2208
Опубликована: Апрель 4, 2024
Abstract
This
review
presents
an
outline
of
current
advancements
in
the
photochemical
and
electrochemical
synthesis
oxazoles
isoxazoles.
Oxazole
isoxazole
are
important
building
blocks
for
a
variety
medicinally
useful
compounds.
Therefore,
these
heterocycles
via
sustainable
technologies
is
worth
demanding.
Photochemical
two
among
few
technologies.
covers
brief
discussion
on
reaction
parameters
like
catalysts,
substrates
scope,
temperature,
solvents,
electrodes,
electrolytes
(in
case
process),
light
source
process)
individual
reaction.
Detailed
mechanistic
insight
each
also
presented.
Finally,
summary,
future
direction
toward
development
effective
methods
isoxazoles
ACS symposium series,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Май 14, 2024
Copper-based
nanomaterials
offer
a
fascinating
array
of
properties
that
make
them
pivotal
in
various
technological
applications.
These
materials,
when
scaled
down
to
the
nanoscale,
exhibit
enhanced
electrical
conductivity,
surpassing
their
bulk
counterparts.
This
book
chapter
primarily
focuses
on
properties,
synthesis,
and
characterization
copper
nanoparticles
while
also
discussing
metal
oxide
nanoparticles.
Their
large
surface-to-volume
ratios
enable
efficient
electron
transport,
making
valuable
components
electronics
conductive
inks
for
flexible
devices.
Furthermore,
possess
exceptional
thermal
crucial
heat
management
advanced
interface
materials.
Copper
have
positive
economic
environmental
effects.
catalytic
render
important
diverse
chemical
reactions
as
energy
storage
systems
like
batteries
supercapacitors.
Additionally,
tunability
optical
makes
suitable
photonic
optoelectronic
applications,
ranging
from
sensors
light-emitting
The
multifaceted
copper-based
continue
drive
innovation
across
broad
spectrum
industries.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(23), С. 4157 - 4165
Опубликована: Окт. 18, 2022
Abstract
We
have
developed
an
electrochemical
method
for
phosphorothiolation
of
2
H
‐indazoles
using
S
‐hydrogen
phosphorothioates
via
cross
dehydrogenative
coupling
reaction
under
metal‐free
and
electrolyte‐free
conditions.
This
protocol
is
compatible
with
electron
donating
groups
like
−Me,
−OMe,
halogen
elctron
withdrawing
such
as
−COOEt,
affording
respective
indazolyl
in
62%‐91%
yields.
Comprehensive
mechanistic
studies
indicate
that
the
proceeds
through
a
radical
pathway.
magnified
image
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(39), С. 7746 - 7764
Опубликована: Янв. 1, 2022
2H-Indazoles
are
one
class
of
the
most
important
nitrogen-containing
heterocyclic
compounds.
The
2H-indazole
motif
is
widely
present
in
bioactive
natural
products
and
drug
molecules
that
exhibit
distinctive
bioactivities.
Therefore,
much
attention
has
been
paid
to
access
diverse
derivatives.
Among
them,
late-stage
functionalization
2H-indazoles
via
C-H
activation
recognized
as
an
efficient
approach
for
increasing
complexity
diversity
In
this
review,
we
summarized
recent
achievements
2H-indazoles,
including
C3-functionalization
through
transition
metal-catalyzed
or
a
radical
pathway,
ortho
C2'-H
remote
at
benzene
ring
2H-indazoles.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(7)
Опубликована: Янв. 19, 2024
Abstract
A
Minisci‐type
carbamoylation
of
azauracils
was
developed
to
afford
6‐carbamoyl
in
yields
up
94
%.
In
this
transformation,
oxamic
acids
were
employed
as
the
carbamoyl
radical
sources
under
metal‐free
conditions.
It
features
high
atom
economy,
good
functional
group
compatibility
and
convenient
operation.
