Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 393 - 419
Опубликована: Ноя. 1, 2024
Язык: Английский
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Язык: Английский
Процитировано
19
Chemical Engineering Journal, Год журнала: 2022, Номер 452, С. 139248 - 139248
Опубликована: Сен. 16, 2022
Язык: Английский
Процитировано
51
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(8), С. 11062 - 11075
Опубликована: Фев. 14, 2023
Conductive hydrogel-based ionic skins have attracted immense attention due to their great application prospects in wearable electronic devices. However, simultaneously achieving a combination of single hydrogel system and excellent comprehensive performance (i.e., mechanical durability, electrical sensitivity, broad-spectrum antibacterial activity, biocompatibility) remains challenge. Thus, novel poly(ionic liquid) consisting poly(acrylamide-co-lauryl methacrylate-co-methyl-uracil-imidazolium chloride-co-2-acryloylamino-2-methyl-1-propane sulfonic acid) (AAm-LMA-MUI-AMPS) was prepared by micellar copolymerization method. Herein, MUI serves as supramolecular crosslinker conductive bacteriostatic components. Owing the multiple crosslinks hydrophobic association network, exhibits properties (624 kPa breaking stress 1243 compression stress), skin-like modulus (46.2 kPa), stretchability (1803%), durability (200 cycles under 500% strain can be completely recovered). Moreover, with coordinated each monomer, unique advantage high conductivity (up 59.34 mS/cm). Hence, further assembled an skin sensor, which exhibited gauge factor (GF) 10.74 7.27 without LiCl over broad range (1-1000%), respectively. Furthermore, sensor could monitor human movement different ranges, including body vocal cord vibration. In addition, activity biocompatibility were investigated. These findings present new strategy for design new-generation devices functions.
Язык: Английский
Процитировано
32
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 331, С. 103244 - 103244
Опубликована: Июнь 26, 2024
Ionic liquids (ILs) play a crucial role in the design of novel materials. The ionic nature ILs provides numerous advantages drug delivery, acting as green solvent or active ingredient to enhance solubility, permeability, and binding efficiency drugs. They could also function structuring agent development nano/micro particles for including micelles, vesicles, gels, emulsion, more. This review summarize IL-based gel structures with their advanced delivery applications. first part focuses on formulation applications delivery. second offers comprehensive overview recent gel. It aims offer new perspectives attract more attention open up avenues biomedical gels.
Язык: Английский
Процитировано
14
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
The rapid increase in the number of stimuli-responsive polymers, also known as smart has significantly advanced their applications various fields. These polymers can respond to multiple stimuli, such temperature, pH, solvent, ionic strength, light, and electrical magnetic fields, making them highly valuable both academic industrial sectors. Recent studies have focused on developing hydrogels with self-healing properties that autonomously recover structural integrity mechanical after damage. hydrogels, formed through dynamic covalent reactions, exhibit superior biocompatibility, responsiveness particularly pH changes. However, conventional are limited by weak brittle nature. To address this, ionizable moieties within polyelectrolytes be tuned create ionically cross-linked leveraging natural alginate, chitosan, hyaluronic acid, cellulose. integration liquids into these enhances conductivity, positioning significant agents. This review focuses emerging field ionic-based explores potential dermal tissue engineering.
Язык: Английский
Процитировано
2
Journal of Molecular Liquids, Год журнала: 2024, Номер 399, С. 124403 - 124403
Опубликована: Март 5, 2024
Ionic liquids (ILs) have a long and successful history of application as materials special interest in various fields, particularly biomedicine. When polymerized at the nanoscale, polymeric ILs (PILs) combine attractive properties with united advantages solid polymer structures nanoparticulate matter. As rapidly developing nanomaterials biomedical importance, they afford new prospects for treatment diseases. In particular, due to their greatly tunable composition, biocompatibility wide specific surface area, PIL nanoparticles offer potential delivery systems different medications. This brief review introduces emerging landscape drug-delivery summarizes actual applications available from recent literature (after 2018). Special attention is paid methods fabricating nano-sized PILs responsible controlled drug release. Critically discussed are diverse examples using nanostructures based on variable morphology designed drug-vehicle vectors. Also brought into focus challenges preclinical development future perspectives nanocarriers.
Язык: Английский
Процитировано
7
Materials Today Physics, Год журнала: 2022, Номер 30, С. 100925 - 100925
Опубликована: Ноя. 21, 2022
Язык: Английский
Процитировано
28
Journal of Materials Chemistry A, Год журнала: 2023, Номер 11(26), С. 14159 - 14168
Опубликована: Янв. 1, 2023
A soft and solid-state poly(ionic liquid) (PIL) filler is synthesized to increase the dielectric constant decrease Young's modulus of composite elastomers, thereby improving actuation performance safety elastomer actuators (DEAs).
Язык: Английский
Процитировано
17
Green Chemistry, Год журнала: 2023, Номер 25(22), С. 9001 - 9019
Опубликована: Янв. 1, 2023
Polymer chains endow PILs with unique aggregation structures and morphologies that are inaccessible to monomeric ILs, making them a sustainable material allowing be used in various applications.
Язык: Английский
Процитировано
17
European Polymer Journal, Год журнала: 2023, Номер 203, С. 112657 - 112657
Опубликована: Дек. 3, 2023
Язык: Английский
Процитировано
12