European Journal of Organic Chemistry, Год журнала: 2022, Номер 2022(48)

Опубликована: Дек. 5, 2022

Abstract A simple, metal‐free, and green approach has been established for N−H functionalization of sulfoximines under mild reaction conditions to offer sulfoximinated‐oxime conjugates. The works well in EtOH at room temperature proceeds smoothly without using any base or expensive ligands. This protocol applied on various aryl‐, heteroaryl‐ as variety chloro‐oximes. Both the substrates tolerated a wide range functional groups, resulting good excellent yields. It can serve directing group organic synthesis, precursor building block, demonstrating product's applicability importance field. applications have demonstrated sulfoximination some natural products. strategy could be useful drug discovery medicinal chemistry fine‐tuning physicochemical properties product scaffolds lead candidates.

Язык: Английский