The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
In
this
work,
a
switchable
synthesis
of
β-ketosulfone
and
α-chloroketone
through
radical
difunctionalization
alkenes
is
reported.
The
transformation
works
well
under
iron
peroxo
species/photoredox
dual
catalysis
an
open-flask
atmosphere,
the
reaction
highlighted
with
good
yields
broad
scope.
Mechanism
studies
show
that
initiated
by
formal
[4
+
2]
cyclization
sulfonyl
in
regioselective
manner.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(5), С. 3509 - 3524
Опубликована: Фев. 16, 2024
A
photocatalytic
annulation
cascade
of
unactivated
N-alkene-linked
indoles
with
Langlois'
reagent
by
a
radical
relay
is
developed
at
room
temperature
under
blue
LED
irradiation.
The
reaction
afforded
series
tri/difluoromethylated
pyrrolo[1,2-a]indoles
in
moderate
to
good
yields.
DFT
study
suggests
that
the
ascribed
rhodamine
6G-induced
cyclization
involving
vinyl
addition-radical
and
hydrogen-atom-abstraction
(HAA)
processes,
interestingly,
are
applied
as
fluorescent
dyes
into
fluorescence
spectrum
live-cell
imaging.
This
paper
represents
an
initial
example
on
cascades
HAA
process.
ACS Catalysis,
Год журнала:
2024,
Номер
14(6), С. 4329 - 4339
Опубликована: Март 6, 2024
An
iron-catalyzed
lactonization
reaction
via
intramolecular
C(sp3)-H
functionalization
is
described.
The
process
employs
easily
accessible
hydroxamate
derivatives
from
which
the
noncommon
insertion
of
oxygen
occurred
through
a
1,5-hydrogen
atom
transfer.
A
mixture
water
and
hexafluoroisopropanol
as
solvent
appeared
to
be
key
parameter
this
transformation
reach
high
selectivity
efficiency.
A
general
and
efficient
method
for
the
direct
alkynylation
oxidation
of
remote
C(sp3)-H
bonds
under
photoirradiation
is
described.
In
this
reaction,
Pd
catalyst
acts
as
both
a
photocatalyst
to
generate
nitrogen
radical
cross-coupling
with
terminal
alkyne.
Attractive
features
system
include
good
functional
group
tolerance,
scalability,
convenient
reagents,
an
operating
system.
The
utility
protocol
highlighted
by
its
application
derivatization
several
valuable
aza-heterocycles
such
caspase-3
inhibitor
azepinone
derivatives.
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 26, 2025
Abstract
Photo‐assisted,
iron‐catalyzed
C─H
functionalizations
represent
nowadays
a
sustainable
tool
to
develop
unprecedented
transformations,
unviable
by
common
catalytic
organometallic
approaches
promoted
transition
metals.
In
fact,
the
use
of
this
new
technology
allows
for
more
efficient
synthetic
transformations
increasing
chemo‐,
regio‐
and
site‐selectivity
catalysis
while
reducing
formation
by‐products
shortening
reaction
times.
Further,
replacement
precious
transition‐metals
with
iron
catalysts
is
highly
desiderable
development
environmentally‐friendly
methods.
Within
review,
we
aim
summarize
latest
achievements
combining
most
abundant
safe
metal
in
“outer‐sphere”
functionalization
reactions
mediated
light
C─C
C─Het
bonds,
including
challenging
C─N,
C─P,
C─B
C─S
bonds.
Particular
attention
has
been
directed
toward
description
mechanistic
aspects
application
methods
late‐stage
polymers,
marketed
drugs,
biologically‐active
compounds
materials.
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
In
this
review,
we
have
showcased
the
diverse
aspects
of
transition-metal
catalysis,
biocatalysis,
and
photocatalytic
C(sp
3
)–H
bond
functionalization
to
access
lactones
lactams.
Chemical Communications,
Год журнала:
2023,
Номер
59(89), С. 13309 - 13312
Опубликована: Янв. 1, 2023
This
study
describes
an
iron-catalyzed
divergent
oxidation
of
styrene
into
β-hydroxylmethylketone
and
ketone
under
photo-irradiation.
divergence
is
ascribed
to
the
use
with
various
substituents.
More
importantly,
methanol
oxidized
formaldehyde
in
reaction
serves
as
a
C1
synthon.
Mechanism
investigations
show
that
initiated
by
oxidative
SET
transfer
cation
radical.
The
pathway
undergoes
HAT
β-hydride
elimination
well
concerted
cyclization.
Particularly,
several
drug-like
molecules,
such
melperone
analogue,
lenperone
haloperidol
are
synthesized.
In
addition,
this
method
also
applicable
synthesis
natural
product
(R)-atomoxetine.
