Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 286 - 286
Опубликована: Фев. 17, 2024
Transdermal
drug
delivery
systems
are
rapidly
gaining
prominence
and
have
found
widespread
application
in
the
treatment
of
numerous
diseases.
However,
they
encounter
challenge
a
low
transdermal
absorption
rate.
Microneedles
can
overcome
stratum
corneum
barrier
to
enhance
Among
various
types
microneedles,
nanoparticle-loaded
dissolving
microneedles
(DMNs)
present
unique
combination
advantages,
leveraging
strengths
DMNs
(high
payload,
good
mechanical
properties,
easy
fabrication)
nanocarriers
(satisfactory
solubilization
capacity
controlled
release
profile).
Consequently,
hold
considerable
clinical
potential
precision
medicine
era.
Despite
this
promise,
no
DMN
products
been
approved
thus
far.
The
lack
understanding
regarding
their
vivo
fate
represents
critical
bottleneck
impeding
translation
relevant
products.
This
review
aims
elucidate
current
research
status
elaborate
necessity
investigate
from
diverse
aspects.
Furthermore,
it
offers
insights
into
entry
points
for
DMNs,
aiming
foster
further
advancements
field.
JACS Au,
Год журнала:
2023,
Номер
3(7), С. 1835 - 1842
Опубликована: Июль 7, 2023
The
design
and
regulation
of
phosphors
are
attractive
but
challenging
because
the
spin-forbidden
intersystem
crossing
(ISC)
process.
Here,
a
new
perspective
on
enhancement
ISC
is
proposed
demonstrated.
Different
from
current
strategies,
yield
(ΦISC)
enhanced
by
decreasing
fluorescence
radiative
transition
rate
constant
(kF)
via
rational
molecular
designing
rather
than
boosting
spin–orbit
coupling
decorating
skeleton
with
heavy
atom,
heteroatom,
or
carbonyl.
kF
designed
molecule
in
this
case
associated
substituent
position
methoxy
group,
which
alters
distribution
front
orbitals.
S0
→
S1
these
compounds
evolves
bright
state
to
dark
gradually
variation
position,
accompanied
decrease
increase
ΦISC.
emission
switched
phosphorescence
successfully
regulating
kF.
This
work
provides
an
alternative
strategy
efficient
room-temperature
material.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(51)
Опубликована: Авг. 26, 2024
Abstract
Pathogenic
infectious
diseases
have
persistently
posed
significant
threats
to
public
health.
Phototheranostics,
which
combines
the
functions
of
diagnostic
imaging
and
therapy,
presents
an
extremely
promising
solution
block
spread
pathogens
as
well
outbreak
epidemics
owing
its
merits
a
wide‐spectrum
activity,
high
controllability,
non‐invasiveness,
difficult
acquire
resistance.
Among
multifarious
phototheranostic
agents,
second
near‐infrared
(NIR‐II,
1000–1700
nm)
aggregation‐induced
emission
luminogens
(AIEgens)
are
notable
by
virtue
their
deep
penetration
depth,
excellent
biocompatibility,
balanced
radiative
nonradiative
decay
aggregation‐enhanced
theranostic
performance,
making
them
ideal
option
for
combating
pathogens.
This
minireview
provides
systematical
summary
latest
advancements
in
NIR‐II
AIEgens
with
emphasis
on
molecular
design
nanoplatform
formulation
fulfill
high‐efficiency
treating
bacterial
viral
pathogens,
classified
disease
models.
Then,
current
challenges,
potential
opportunities,
future
research
directions
presented
facilitate
further
progress
this
emerging
field.
