Chemistry of Heterocyclic Compounds, Год журнала: 2023, Номер 59(8), С. 525 - 533
Опубликована: Авг. 1, 2023
Язык: Английский
Chemistry of Heterocyclic Compounds, Год журнала: 2023, Номер 59(8), С. 525 - 533
Опубликована: Авг. 1, 2023
Язык: Английский
Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(8), С. 6851 - 6879
Опубликована: Авг. 17, 2023
The search for new drugs has been greatly accelerated by the emergence of viruses and drug-resistant strains known pathogens. Nucleoside analogues (NAs) are a prospective class antivirals due to safety profiles, which important rapid repurposing in fight against emerging Recent improvements research methods have revealed unexpected details mechanisms action NAs that can pave way approaches further development effective drugs. This review accounts advanced techniques viral polymerase targeting, host enzyme targeting approaches, prodrug-based strategies antiviral NAs.
Язык: Английский
Процитировано
19Natural Product Reports, Год журнала: 2024, Номер 41(6), С. 873 - 884
Опубликована: Янв. 1, 2024
This Highlight offers a perspective on recent strategies for synthesising purine nucleoside antibiotics, an untapped source of natural products developing novel antimicrobial agents.
Язык: Английский
Процитировано
9Critical Reviews in Biotechnology, Год журнала: 2024, Номер unknown, С. 1 - 21
Опубликована: Авг. 12, 2024
Natural products have long served as critical raw materials in chemical and pharmaceutical manufacturing, primarily which can provide superior scaffolds or intermediates for drug discovery development. Over the last century, natural contributed to more than a third of therapeutic production. However, traditional methods producing drugs from become less efficient expensive over past few decades. The combined utilization genome mining synthetic biology based on sequencing, bioinformatics tools, big data analytics, genetic engineering, metabolic systems promises counter this trend. Here, we reviewed recent (2020–2023) examples used resolve challenges production products, such variety, poor efficiency, low yield. Additionally, emerging design principles, building strategies its application prospects NPs synthesis also been discussed.
Язык: Английский
Процитировано
9ACS Infectious Diseases, Год журнала: 2024, Номер 10(5), С. 1780 - 1792
Опубликована: Апрель 23, 2024
The recent COVID-19 pandemic underscored the limitations of currently available direct-acting antiviral treatments against acute respiratory RNA-viral infections and stimulated major research initiatives targeting anticoronavirus agents. Two novel nsp5 protease (MPro) inhibitors have been approved, nirmatrelvir ensitrelvir, along with two existing nucleos(t)ide analogues repurposed as nsp12 polymerase inhibitors, remdesivir molnupiravir, but a need still exists for therapies improved potency systemic exposure oral dosing, better metabolic stability, reduced resistance toxicity risks. Herein, we summarize our toward identifying that led to nucleoside 10e 10n, which showed favorable pan-coronavirus activity in cell-infection screens, were metabolized active triphosphate nucleotides cell-incubation studies, demonstrated target (nsp12) engagement biochemical assays.
Язык: Английский
Процитировано
5Organic Letters, Год журнала: 2024, Номер 26(6), С. 1212 - 1217
Опубликована: Фев. 1, 2024
As an inexpensive industrial chemical, chlorodifluoromethane (Freon-22), despite its relatively low reactivity, can serve as a practical CF
Язык: Английский
Процитировано
4Tetrahedron Chem, Год журнала: 2024, Номер 9, С. 100068 - 100068
Опубликована: Фев. 24, 2024
Язык: Английский
Процитировано
3Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
Comprehensive Summary Dragocins A—C are structurally unique marine natural products featuring an uncommon tri‐oxa‐tricyclic[6.2.1]undecane moiety. However, their extremely low abundance has hindered extensive screening of bioactivities. We hereby describe efficient and modular approach to synthesizing dragocins analogues using commercially available inexpensive anisomycin D‐ribosyl thioglycoside derivative as the starting materials. A key feature our synthesis is construction skeleton. This challenging architecture achieved by stereocontrolled formation β‐ribofuranosidic bond DDQ (2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone)‐promoted intramolecular cross‐dehydrogenative etherification at benzylic position. Our also characterized successful installation a chlorine atom methoxy group tertiary C‐4' position via late‐stage silver‐catalyzed decarboxylative chlorination reaction electrophilic enol intermediate. Cytotoxicity evaluations synthesized compounds revealed demethyl dragocin A, N ‐demethylated potential anticancer candidate due its strong cytotoxicity against A549 lung, HCT116 colorectal MCF7 breast cancer cell lines. work demonstrated preliminary structure‐activity relationship this compound, setting solid foundation for developing novel candidates.
Язык: Английский
Процитировано
0Bioorganic & Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 118243 - 118243
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Molecular Catalysis, Год журнала: 2023, Номер 547, С. 113360 - 113360
Опубликована: Июль 7, 2023
Язык: Английский
Процитировано
6European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(31)
Опубликована: Июль 12, 2023
Abstract A visible light‐induced perfluoroalkylative cyclization of 3‐aza‐1,5‐dienes leading to pentasubstituted 1,3‐dihydropyrrole‐2‐ones is presented. The reaction regiospecific, for the radical adds across acrylamido moiety, whereas enaminic double bond functions as a built‐in trap. It could be carried out on 2‐gram scale, and sunlight usable light source. Other virtues protocol include short time, low catalyst loading, mild conditions broad substrate scope.
Язык: Английский
Процитировано
6