Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges

Advanced Functional Materials, Год журнала: 2024, Номер 34(16)

Опубликована: Янв. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Язык: Английский

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Single‐Atom Manganese‐Catalyzed Oxygen Evolution Drives the Electrochemical Oxidation of Silane to Silanol

Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(3)

Опубликована: Дек. 7, 2023

The oxygen evolution reaction (OER), characterized by a four-electron transfer kinetic process, represents significant bottleneck in improving the efficiency of hydrogen production from water electrolysis. Consequently, extensive research efforts have been directed towards identifying single-atom electrocatalysts with exceptional OER performance. Despite comprehensive understanding mechanism, its application to other valuable synthetic reactions has limited. Herein, we leverage MOOH intermediate, key species Mn-N-C catalyst (Mn-SA@NC), which can be cyclically delivered OER. We exploit this intermediate' s capability facilitate electrophilic silane, enabling efficient silane oxidation under electrochemical conditions. SAC electrocatalytic system exhibits remarkable performance loadings as low 600 ppm and an turnover number 9132. Furthermore, catalytic method demonstrates stability 10 mmol flow chemistry setup. By serving electrocatalyst, Mn-SA@NC drives entire reaction, establishing practical Mn SAC-catalyzed organic electrosynthesis system. This synthesis approach not only presents promising avenue for utilization but also highlights potential SACs attractive platform investigations.

Язык: Английский

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Atomic-level coordination structures meet graphitic carbon nitride (g-C3N4) for photocatalysis: Energy conversion and environmental remediation

Applied Catalysis B Environment and Energy, Год журнала: 2024, Номер unknown, С. 123683 - 123683

Опубликована: Янв. 1, 2024

Язык: Английский

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Accelerating photocatalytic hydrogen production by anchoring Pt single atoms on few-layer g-C₃N₄ nanosheets with Pt–N coordination

Journal of Materials Chemistry C, Год журнала: 2024, Номер 12(10), С. 3437 - 3449

Опубликована: Янв. 1, 2024

g-C 3 N 4 nanosheets are modified with Pt single atoms at 1.5 at% through a low-temperature incipient wetness impregnation method followed by high-temperature pyrolysis, increasing the photocatalytic H 2 production rate two orders of magnitude.

Язык: Английский

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NIR-enhanced Pt single atom/g-C3N4 nanozymes as SOD/CAT mimics to rescue ATP energy crisis by regulating oxidative phosphorylation pathway for delaying osteoarthritis progression

Bioactive Materials, Год журнала: 2024, Номер 36, С. 1 - 13

Опубликована: Фев. 21, 2024

Osteoarthritis (OA) progresses due to the excessive generation of reactive oxygen and nitrogen species (ROS/RNS) abnormal ATP energy metabolism related oxidative phosphorylation pathway in mitochondria. Highly active single-atom nanozymes (SAzymes) can help regulate redox balance have shown their potential treatment inflammatory diseases. In this study, we innovatively utilised ligand-mediated strategies chelate Pt

Язык: Английский

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Hybridization State Transition under Working Conditions: Activity Origin of Single-Atom Catalysts

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(22), С. 15640 - 15647

Опубликована: Май 21, 2024

Single-atom catalysts (SACs) have been widely investigated and emerged as a transformative approach in electrocatalysis. Despite their clear structure, the origin of exceptional activity remains elusive. Herein, we elucidate common phenomenon hybridization state transition metal centers, which is responsible for across various SACs different reactions. Focusing on N-doped carbon-supported Ni SAC (NiN4 SAC) CO2 reduction reaction (CO2RR), our comprehensive computations successfully clarify under working conditions its relation with activity. This transition, triggered by intermediates applied potential, converts center from inert dsp2 to active d2sp3 state. Importantly, calculated selectivity CO2RR over d2sp3-hybridized are consistent experimental results, offering strong support proposed hypothesis. work suggests universal principle electronic structure evolution that could revolutionize catalyst design, also introduces new paradigm manipulating states enhance catalytic performance, implications reactions platforms.

Язык: Английский

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Single‐Atom Iron Catalyst as an Advanced Redox Mediator for Anodic Oxidation of Organic Electrosynthesis

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(27)

Опубликована: Апрель 23, 2024

Homogeneous electrocatalysts can indirect oxidate the high overpotential substrates through single-electron transfer on electrode surface, enabling efficient operation of organic electrosynthesis catalytic cycles. However, problems this chemistry still exist such as dosage, difficult recovery, and low efficiency. Single-atom catalysts (SACs) exhibit atom utilization excellent activity, hold great promise in addressing limitations homogeneous catalysts. In view this, we have employed Fe-SA@NC an advanced redox mediator to try change situation. was synthesized using encapsulation-pyrolysis method, it demonstrated remarkable performance a range reported reactions, construction various C-C/C-X bonds. Moreover, potential exploring new synthetic method for electrosynthesis. We develop electro-oxidative ring-opening transformation cyclopropyl amides. reaction system, showed good tolerance drug molecules with complex structures, well flow electrochemical syntheses gram-scale transformations. This work highlights SACs electrosynthesis, thereby opening avenue chemistry.

Язык: Английский

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Materials Containing Single‐, Di‐, Tri‐, and Multi‐Metal Atoms Bonded to C, N, S, P, B, and O Species as Advanced Catalysts for Energy, Sensor, and Biomedical Applications

Advanced Science, Год журнала: 2024, Номер 11(33)

Опубликована: Июль 1, 2024

Abstract Modifying the coordination or local environments of single‐, di‐, tri‐, and multi‐metal atom (SMA/DMA/TMA/MMA)‐based materials is one best strategies for increasing catalytic activities, selectivity, long‐term durability these materials. Advanced sheet supported by metal atom‐based have become a critical topic in fields renewable energy conversion systems, storage devices, sensors, biomedicine owing to maximum utilization efficiency, precisely located centers, specific electron configurations, unique reactivity, precise chemical tunability. Several offer excellent support are attractive applications energy, medical research, such as oxygen reduction, production, hydrogen generation, fuel selective detection, enzymatic reactions. The strong metal–metal metal–carbon with metal–heteroatom (i.e., N, S, P, B, O) bonds stabilize optimize electronic structures atoms due interfacial interactions, yielding activities. These provide models understanding fundamental problems multistep This review summarizes substrate structure‐activity relationship different active sites based on experimental theoretical data. Additionally, new synthesis procedures, physicochemical characterizations, biomedical discussed. Finally, remaining challenges developing efficient SMA/DMA/TMA/MMA‐based presented.

Язык: Английский

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Atmosphere Engineering of Metal-Free Te/C3N4 p-n Heterojunction for Nearly 100% Photocatalytic Converting CO2 to CO

Advanced Powder Materials, Год журнала: 2024, Номер unknown, С. 100243 - 100243

Опубликована: Сен. 1, 2024

Язык: Английский

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Metal‐Free Modification Overcomes the Photocatalytic Limitations of Graphitic Carbon Nitride: Efficient Production and In Situ Application of Hydrogen Peroxide

Advanced Energy Materials, Год журнала: 2024, Номер 14(39)

Опубликована: Июль 22, 2024

Abstract Graphitic carbon nitride (g‐C 3 N 4 ) assisted photocatalytic production of hydrogen peroxide (H 2 O has already attracted the interest many researchers due to its environmental sustainability. Nevertheless, inherent drawbacks g‐C limit progress. Metal‐free modification strategies, including nanostructure design, defect introduction, doping, and heterojunction construction, have been developed improve efficiency H production. Compared metal modification, metal‐free strategies avoid use precious metals leaching heavy ions, which advantages good stability friendliness. However, a comprehensive review from modified by is still lacking. This first recaps mechanism , photoexcitation, carrier separation redox reactions. Then, perspective advances in photocatalysts are presented, with special focus on kernel connection between different based pivotal stages Subsequently, recent applications ‐based for situ generated mainly water purification organic synthesis, briefly discussed. Finally, prospects envisioned hope that it will “something do” field

Язык: Английский

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