Human
sweat
has
the
potential
to
be
sufficiently
utilized
for
noninvasive
monitoring.
Given
complexity
of
secretion,
sensitivity
and
selectivity
monitoring
should
further
improved.
Here,
we
developed
an
olfactory-inspired
separation-sensing
nanochannel-based
electronic
sensitive
selective
monitoring,
which
was
simultaneously
endowed
with
interferent
separation
target
detection
performances.
The
special
strategy
imparts
functional
composite
membranes
a
high
113
mV
dec–1
potassium
detection.
excellent
mechanical
properties
conformability
Kevlar
aramid
nanofiber
layer
bring
well-wearing
performances
realize
continuous
wireless
recognition
between
molecules
ions
is
proved
at
molecular
level
in
detail
article.
replacement
proves
universality
performance
enhancement
intricate
biofluid
analysis
systems.
Advanced Materials,
Год журнала:
2024,
Номер
36(18)
Опубликована: Янв. 19, 2024
Abstract
Effective
detection
of
bio‐molecules
relies
on
the
precise
design
and
preparation
materials,
particularly
in
laser
desorption/ionization
mass
spectrometry
(LDI‐MS).
Despite
significant
advancements
substrate
performance
single‐structured
substrates
remains
suboptimal
for
LDI‐MS
analysis
complex
systems.
Herein,
designer
Au@SiO
2
@ZrO
core‐shell
are
developed
LDI‐MS‐based
early
diagnosis
prognosis
pancreatic
cancer
(PC).
Through
controlling
Au
core
size
ZrO
shell
crystallization,
signal
amplification
metabolites
up
to
3
orders
is
not
only
achieved,
but
also
synergistic
mechanism
LDI
process
revealed.
The
optimized
enables
a
direct
record
serum
metabolic
fingerprints
(SMFs)
by
LDI‐MS.
Subsequently,
SMFs
employed
distinguish
PC
(stage
I/II)
from
controls,
with
an
accuracy
92%.
Moreover,
prognostic
prediction
scoring
system
established
enhanced
efficacy
predicting
survival
compared
CA19‐9
(p
<
0.05).
This
work
contributes
material‐based
prognosis.
ACS Sensors,
Год журнала:
2024,
Номер
9(5), С. 2540 - 2549
Опубликована: Апрель 18, 2024
Clinical
diagnosis
of
ovarian
cancer
lacks
high
accuracy
due
to
the
weak
selection
specific
biomarkers
along
with
circumstance
localization.
Clustering
analysis
proteins
transported
on
exosomes
enables
a
more
precise
screening
effective
biomarkers.
Herein,
through
bioinformatics
and
exosome
proteomes,
two
coexpressed
proteins,
EpCAM
CD24,
specifically
enriched,
were
identified,
together
development
an
as-derived
dual-aptamer
targeted
exosome-based
strategy
for
screening.
In
brief,
DNA
ternary
polymer
aptamers
targeting
CD24
was
designed
present
logic
gate
reaction
upon
recognizing
exosomes,
triggering
rolling
circle
amplification
chemiluminescent
signal.
A
dynamic
detection
range
6
orders
magnitude
achieved
by
quantifying
exosomes.
Moreover,
clinical
samples,
this
could
accurately
differentiate
from
healthy
persons,
other
patients,
enabling
promising
ACS Nano,
Год журнала:
2024,
Номер
18(12), С. 9043 - 9052
Опубликована: Март 14, 2024
Natural
organisms
have
evolved
various
biological
ion
channels
to
make
timely
responses
toward
different
physical
and/or
chemical
stimuli,
giving
guidance
construct
artificial
counterparts
and
expand
the
corresponding
applications.
They
also
shown
promising
potential
overcome
disadvantages
of
traditional
electronic
devices
(e.g.,
energy-consuming
operation
adverse
humidity
interference).
Herein,
we
constructed
a
green
alga-inspired
nanofluidic
system
based
on
Janus
dual-field
heterogeneous
membrane
(i.e.,
J-HM),
which
can
function
underwater
as
an
visual
platform
for
light
perception
through
enhanced
active
transport.
The
J-HM
was
obtained
sequentially
assembled
MXene
Cu-HHTP
metal–organic
framework
reaction
between
2,3,6,7,10,11-hexahydroxytriphenylene
hydrate
(HHTP)
Cu2+)
building
units.
Due
formed
temperature
gradient
intramembrane
electric
field
caused
by
localized
thermal
excitation
efficient
charge
separation
under
illumination,
thermo-osmotic
photo-driven
forces
are
generated
preferential
cation
transport
from
MXene.
Furthermore,
unidirectional
be
self-diffusion
concentration
gradient.
Then,
perceptions
at
illumination
conditions
explored,
showing
nearly
linear
correlation
with
intensity.
Finally,
it
is
demonstrated
that
achieve
object
shape,
definition,
distance
recognition
using
defined
pixelated
matrix,
impetus
develop
ionic
signal
transmission
sensing
systems.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Март 30, 2024
Abstract
Through
evolution,
biological
organisms
have
developed
ways
to
sense
light
using
ion
channels,
which
holds
several
advantages,
such
as
energy
efficiency
and
water
resistance,
over
humanmade
optoelectronic
devices.
Herein,
a
retina‐inspired
nanofluidic
system
is
presented
with
Janus
heterogeneous
membrane
(J‐HM),
can
achieve
underwater
visual
imaging
through
light‐driven
active
transport.
The
J‐HMs
are
obtained
sequentially
assembled
WS
2
,
kind
of
metal–organic
framework
nanosheets
via
the
reaction
between
2,3,6,7,10,11‐hexahydroxytriphenylene
hydrate
(HHTP)
Cu
2+
(Cu‐HHTP).
Due
formed
intramembrane
electric
field
caused
by
efficient
charge
separation
under
illumination,
photovoltaic
driving
force
generated
for
transport
from
Cu‐HHTP
.
Furthermore,
unidirectionally
be
enhanced
self‐diffusion
concentration
gradient.
J‐HM
single‐pixel
design
shows
nearly
linear
response
intensity
has
enough
resolution
basic
object
recognition
well
long‐term
memory
after
data
processing
defined
pixelated
matrix,
pave
an
avenue
designing
more
intelligent
sensing
systems.
ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12412 - 12426
Опубликована: Май 2, 2024
Glycans
play
vital
roles
in
nearly
all
life
processes
of
multicellular
organisms,
and
understanding
these
activities
is
inseparable
from
elucidating
the
biological
significance
glycans.
However,
glycan
research
has
lagged
behind
that
DNA
protein
due
to
challenges
posed
by
structural
heterogeneity
isomerism
(i.e.,
structures
with
equal
molecular
weights)
lack
high-efficiency
analysis
techniques.
Nanopore
technology
emerged
as
a
sensitive
single-molecule
biosensor,
shining
light
on
analysis.
significant
number
glycans
are
small
uncharged,
making
it
challenging
elicit
identifiable
nanopore
signals.
Here
we
introduce
Accounts of Chemical Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
ConspectusPrecise
and
rapid
detection
of
key
biomolecules
is
crucial
for
early
clinical
diagnosis.
These
critical
biomarkers
are
typically
present
at
low
concentrations
within
complex
environments,
presenting
significant
challenges
their
accurate
reliable
detection.
Nowadays,
electrochemical
sensors
based
on
nanochannel
membranes
have
attracted
attention
due
to
high
sensitivity,
simplicity,
response,
label-free
point-of-care
capabilities.
The
confined
arena
provided
by
the
nanochannels
target
recognition
interactions
facilitates
signal
amplification,
leading
enhanced
performance.
also
can
act
as
filters
repel
interferents
enable
in
more
environments.
Thus,
considered
promising
platforms
biosensing
applications.
However,
such
uncontrollable
structures
unstable
performance
some
materials
limit
applications
theoretical
advancements.
To
investigate
relationship
between
architecture
sensing
achieve
efficient
performance,
it
essential
construct
with
precise
nanostructures
possessing
stable
properties.
With
development
nanomaterials
technology,
mesoporous
robust,
controllable,
ordered
mesostructures,
along
tunable
surface
properties
tailored
ion
transport
dynamics,
emerged
candidates
achieving
Additionally,
investigating
mechanisms
influencing
factors
will
provide
valuable
insights
into
optimizing
sensor
enhancing
efficiency
reliability
technologies.
In
this
Account,
we
highlight
substantial
advancements
membranes,
which
mainly
research
work
published
our
group.
first
section,
explore
underlying
processes,
including
solid-liquid
interfacial
nanoconfinement
effects
(i.e.,
electrostatic
interactions,
hydrophilic/hydrophobic
steric
hindrance
effects).
We
delve
parameters
geometry,
materials,
elements,
external
related
impacts
particular,
point
out
that
three-dimensional
interconnected
networks
facilitate
penetration
lead
an
increased
number
binding
sites,
contributing
sensitivity.
composite
or
multilevel
particularly
when
integrated
stimuli
pH,
light,
heat,
introduce
unexpected
properties,
understandings
fundamental
principles
pertinent
design
intelligent,
high-quality
nanofluidic
devices.
Furthermore,
conduct
analysis
integrating
various
strategies,
offers
opportunities
biomedical
monitoring,
disease
diagnosis,
pharmaceutical
industry.
Finally,
describe
future
directions
potential
commercial
adoption.
Nanochannel
novel
structures,
functional
porous
may
new
trends
applications,
self-powered
wearable
monitoring.
believe
Account
holds
implications
promoting
interdisciplinary
endeavors
encompassing
chemistry
science
nanotechnology
well
analysis,
biosensing,
science.
Solid-state
nanopore
and
nanochannel
biosensors
have
revolutionized
protein
detection
by
offering
label-free,
highly
sensitive
analyses.
Traditional
sensing
systems
(1st
2nd
stages)
primarily
focus
on
inner
wall
(IW)
interactions,
facing
challenges
such
as
complex
preparation
processes,
variable
entry
angles,
conformational
changes,
leading
to
irregular
events.
To
address
these
limitations,
recent
advancements
(3rd
stage)
shifted
toward
outer
surface
(OS)
functionalization
but
are
constrained
single-protein
recognition
models.
Herein,
we
show
a
machine
learning
assisted
nanofluidic
array
(MANY)
system
(4th
that
integrates
supervised
dimensionality
reduction
strategy
with
photoresponsive
MoS2
functionalized
nonspecific
functional
elements
(FEarray)
at
the
OS.
This
approach
serves
proof-of-concept
for
probe-free
of
multiple
proteins
100%
accuracy,
highlighting
its
significant
potential
rapid
diagnostics
in
future
disease
applications.
