Dipyrroethene-Based Red-Light Emissive AIEgens DOI
Debasish Mandal,

Saugat Mondal,

Abani Sarkar

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Aggregation-induced emission (AIE) molecules find myriads of applications in various fields ranging from biomedical probes and chemical sensors to optoelectronics. In this domain, tetraphenylethene (TPE) its derivatives have long been a benchmark due their unique luminescent properties aggregated states. However, the limited tunability through further functionalization absorption spectrum higher-energy regions constrain multiple domains. To address these limitations, we designed new class highly symmetric red-light emissive AIE-active by structurally engineering E-dipyrroethene (DPE) skeleton. This design enables pre- postsynthetic modification opportunities two pyrrole rings heteroatoms, facilitating tunable photophysical properties. context, DPE-based AIEgens Tz BTz were synthesized selective α,α-diformylation DPE followed condensation with 2-aminothiazole 2-aminobenzothiazole, respectively. The π-extended conjugation systems containing heteroatoms tune excitation spectra visible wavelength above 600 nm large Stokes shift range 3632-5058 cm-1. Moreover, provides great platform for numerous noncovalent interactions, which significantly enhance aggregation- solid-state fluorescence Furthermore, experimental, spectroscopic, theoretical studies X-ray crystallography measurements elucidate structure-property relationships molecules, pave way development novel materials sensing bioimaging. As proof concept, potential has successfully demonstrated vapor- solution-phase dynamic acid-base stimuli-responsive smart sensors, as well application molecule live-cell imaging.

Язык: Английский

Recent advances in super-resolution optical imaging based on aggregation-induced emission DOI

Feng-Yu Zhu,

Li‐Jun Mei,

Rui Tian

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(7), С. 3350 - 3383

Опубликована: Янв. 1, 2024

Super-resolution imaging has rapidly emerged as an optical microscopy technique, offering advantages of high resolution over the past two decades; achieving improved requires significant efforts in developing super-resolution agents characterized by brightness, contrast and sensitivity to fluorescence switching. Apart from technical requirements systems algorithms, relies on fluorescent dyes with special photophysical or photochemical properties. The concept aggregation-induced emission (AIE) was proposed 2001, coinciding unprecedented advancements innovations technology. AIE probes offer many advantages, including brightness aggregated state, low background signal, a larger Stokes shift, ultra-high photostability, excellent biocompatibility, making them highly promising for applications imaging. In this review, we summarize progress implementation methods provide insights into mechanism AIE-based imaging, switching resulting photochemically-converted emission, electrostatically controlled specific binding-regulated emission. Particularly, principle been achieve spontaneous switching, expanding selection application scenarios probes. By combining molecular design, some comprehensive facilitate AIEgens (AIE-active molecules)

Язык: Английский

Процитировано

47
Electrophilicity Modulation for Sub‐ppm Visualization and Discrimination of EDA DOI Creative Commons
Hao Zhao, Yuan Liu, Gaosheng Li

и другие.

Advanced Science, Год журнала: 2024, Номер 11(18)

Опубликована: Март 6, 2024

Abstract Precise and timely recognition of hazardous chemical substances is great significance for safeguarding human health, ecological environment, public security, etc., especially crucial adopting appropriate disposition measures. Up to now, there remains a practical challenge sensitively detect differentiate organic amines with similar structures intuitive analysis outcomes. Here, unique optical probe two electrophilic sites rapid ultra‐sensitive ratiometric fluorescence detection ethylenediamine (EDA) presented, while producing distinct signals its structural analog. The exhibits ppb/nmol level sensitivity liquidous gaseous EDA, specific toward EDA without disturbance up 28 potential interferents, as well response within 0.2 s. By further combining the portable sensing chip convolutional algorithm endowed image processing, this work cracked problem precisely discriminating target non‐targets at extremely low concentrations.

Язык: Английский

Процитировано

11
Xanthene-Based NIR organic phototheranostics agents: Design strategies and biomedical applications DOI
Xiao‐Yun Ran, Yuanfeng Wei, Yanling Wu

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Near-infrared fluorescence imaging is key in biological exploration. Short emission wavelengths of xanthene dyes limit their use. Structural modifications shift emissions to the NIR-I/II range, enhancing biomedical applications.

Язык: Английский

Процитировано

1
Amphiphilic hemicyanine molecular probes crossing the blood-brain barrier for intracranial optical imaging of glioblastoma DOI Creative Commons
Wei Qin,

Honghui Li,

Jiali Chen

и другие.

Science Advances, Год журнала: 2025, Номер 11(3)

Опубликована: Янв. 15, 2025

Intracranial optical imaging of glioblastoma (GBM) is challenging due to the scarcity effective probes with blood-brain barrier (BBB) permeability and sufficient depth. Herein, we describe a rational strategy for designing crossing BBB based on an electron donor-π-acceptor system adjust lipid/water partition coefficient molecular weight probes. The amphiphilic hemicyanine dye (namely, IVTPO), which exhibits remarkable properties permeability, chosen as efficient fluorescence/photoacoustic probe in vivo real-time orthotopic GBM high resolution through intact skull. Abnormal leakage IVTPO adjacent developing tumor unambiguously observed at early stage development prior impairment integrity, assessed by commercial Evans blue (EB). Compared EB, demonstrates enhanced capability improved tumor-targeting efficacy. These results offer encouraging insights into medical diagnosis intracranial GBM.

Язык: Английский

Процитировано

1
Tailoring Rhodamine Probes: Oxyethylene Chains, Conjugation, and End Substituents in the Quest for Superior Hg2+ Sensing DOI Creative Commons

Harshal V. Barkale,

Nilanjan Dey

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(6)

Опубликована: Фев. 10, 2024

Abstract This study explores the impact of incorporating oxyethylene (OE) chains into rhodamine‐based dye molecules for enhancement photophysical properties in context chemical sensing. The introduction OE provides several advantages, including improved water solubility, photostability and resistance to self‐assembled nanoaggregates formation. Despite these, compound with showed poor response (~2‐fold) towards Hg 2+ ions than that dimeric probe (~20 fold) no such substituents. Notably, shows a remarkable three‐fold larger ion compared monomeric compound. intriguing outcome is attributed extended conjugation within structure, which can induce conformational change overall molecule. Moreover, investigates effects end substituents, as electron‐donating (−OMe, response) electron‐withdrawing (−NO 2 , groups, on interaction ions. excellent sensitivity also evident significantly low detection limits (5–8 ppb) real‐life samples. high recovery values (>95 %) sufficient standard deviation (<5%) indicates quantitative analysis achievable using current protocol. Beyond that, we have employed 1 intracellular (HEK293T cells) fluorescence imaging .

Язык: Английский

Процитировано

8
Semiconducting polymer dots for multifunctional integrated nanomedicine carriers DOI Creative Commons
Ze Zhang, Chenhao Yu, Yuyang Wu

и другие.

Materials Today Bio, Год журнала: 2024, Номер 26, С. 101028 - 101028

Опубликована: Март 24, 2024

The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.

Язык: Английский

Процитировано

8
A lysosome-targeted fluorescent probe for fluorescence imaging of hypochlorous acid in living cells and in vivo DOI
Ke An, Jiaxin Fan, Bin Lin

и другие.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 316, С. 124316 - 124316

Опубликована: Апрель 19, 2024

Язык: Английский

Процитировано

8
A Sequentially Activated Probe for Imaging of Superoxide Anion and Peroxynitrite in PC12 Cells under Oxidative Stress DOI
Ying Li, Jing Cao, Xue Wu

и другие.

Analytical Chemistry, Год журнала: 2024, Номер 96(18), С. 7138 - 7144

Опубликована: Апрель 27, 2024

Superoxide anion (O2·–) and peroxynitrite (ONOO–), two important oxidants under oxidative stress, coexist in complex cell organism systems, playing crucial roles various physiological pathological processes, particularly neurodegenerative diseases. Despite the absence of robust molecular tools capable simultaneously visualizing O2·– ONOO– biosystems, relationship between these species remains understudied. Herein, we present sequentially activated fluorescent probe, DHX-SP, which exhibits exceptional selectivity sensitivity toward ONOO–. This probe enables precise imaging living PC12 cells stress conditions using distinct fluorescence signal combinations. Furthermore, DHX-SP has ability to visualize changes levels during ferroptosis Parkinson's disease model. These findings establish a connection crosstalk phosphorus group stress.

Язык: Английский

Процитировано

7
Bifunctional mitochondria-targeting fluorescence probe for in vivo ONOO− and viscosity sensing without signal crosstalk DOI
Qian Chen, Shen Lin,

Jia-Lin Cui

и другие.

Sensors and Actuators B Chemical, Год журнала: 2024, Номер unknown, С. 136686 - 136686

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

5
Synthesis and Photophysical Properties of β-Alkenyl-Substituted BODIPY Dyes by Indium(III)-Catalyzed Intermolecular Alkyne Hydroarylation DOI Creative Commons
Ana Da Lama, José Pérez Sestelo, Luis A. Sarandeses

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(7), С. 4702 - 4711

Опубликована: Март 19, 2024

A new atom-economical synthesis of β-alkenyl-substituted BODIPYs via indium(III)-catalyzed intermolecular alkyne hydroarylation with meso-substituted is described. While catalysis InI3 allows the double β-functionalization BODIPY, resulting in regioselectively branched β,β′-disubstituted alkenyl BODIPYs, catalytic InCl3 enables formation linear β-substituted BODIPYs. Subsequent In(III)-catalyzed unsymmetrical push–pull BODIPY derivatives. Therefore, indium offers complementary regioselectivity good chemical yields and functional group tolerance. The dyes displayed bathochromically shifted absorption emission according to electron-nature substituents moiety high molar extinction coefficients (ε up 88,200 M–1 cm–1) quantum (0.14–0.96).

Язык: Английский

Процитировано

4