Intermediates in Mechanochemical Reactions DOI
Karen J. Ardila‐Fierro, José G. Hernández

Angewandte Chemie, Год журнала: 2024, Номер 136(14)

Опубликована: Янв. 5, 2024

Abstract Mechanochemical reactions offer methodological and environmental advantages for chemical synthesis, constantly attracting attention within the scientific community. Besides unmistakable sustainability advantages, conditions under which mechanochemical occur, namely solventless conditions, sometimes facilitate isolation of otherwise labile or inaccessible products. Despite these limited knowledge exists regarding mechanisms types intermediates involved. Nevertheless, in an expanding number cases, ex situ monitoring techniques have allowed observation, characterization, reaction transformations. In this Minireview, we present a series examples reactive been detected spanning organic, organometallic, inorganic, materials chemistry. Many were stabilized by non‐covalent interactions, played pivotal role guiding We believe that uncovering understanding such instances, growing mechanochemistry community could find novel opportunities catalysis discover new while achieving simplification design.

Язык: Английский

Nickel-catalyzed cross-coupling aminations via high-throughput mechanochemistry enabled by resonant acoustic mixing DOI Creative Commons
Alice Nanni,

Deshen Kong,

Chen Zhu

и другие.

Green Chemistry, Год журнала: 2024, Номер 26(14), С. 8341 - 8347

Опубликована: Янв. 1, 2024

Resonant Acoustic Mixing (RAM) allows High Throughput Experimentation (HTE) using commercially available 96-well plates as exemplified by the nickel catalyzed C–N cross coupling of aryl halides with different amine and anilines.

Язык: Английский

Процитировано

6

Lighting up industrial mechanochemistry: Real-time in situ monitoring of reactive extrusion using energy-dispersive X-ray diffraction DOI Creative Commons
Nikita Y. Gugin, Kirill V. Yusenko, Andrew King

и другие.

Chem, Год журнала: 2024, Номер 10(11), С. 3459 - 3473

Опубликована: Авг. 28, 2024

Язык: Английский

Процитировано

6

Sustainable Synthesis through Catalyst‐Free Photoinduced Cascaded Bond Formation DOI
Rosalin Bhanja, Shyamal Kanti Bera, Prasenjit Mal

и другие.

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(14)

Опубликована: Май 8, 2024

The beginning of photochemical reactions revolutionized synthetic chemistry through sustainable practices. This review explores cutting-edge developments in leveraging light-induced processes for generating cascaded C-C and C-hetero bonds without catalysts. Significantly, catalyst-free photoinduced methodologies have garnered considerable attention, especially the creation varied heterocyclic frameworks drug design synthesis natural products. article delves into underlying mechanisms, addresses limitations, evaluates various methodologies, emphasizing potential photocatalyst transition metal-free to enhance sustainability. Divided two sections, it covers recent strides C-heteroatom multiple bond formation reactions.

Язык: Английский

Процитировано

5

Mechanochemistry in Organic Synthesis: An Italian Journey through Innovations DOI Creative Commons
Francesco Basoccu, Lidia De Luca, Andrea Porcheddu

и другие.

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(30)

Опубликована: Май 18, 2024

Abstract Mechanochemistry, as an enabling technology, harnesses mechanical force to drive chemical reactions, presenting compelling advantages in organic synthesis within the principles of green chemistry. This review explores how its unique and alignment with sustainable practices have been widely developed different scientific fields Italy. As a transformative strategy for synthesis, mechanochemistry has portrayed this valuable synthetic alternative due various advantages, such solvent reduction new reaction pathways, that use brings. Nonetheless, improvements brought about by also crucial other chemistry described Italian scientists. In whole context, researchers analysed both already optimised processes feasible paving way avenues previously hampered all limitations belong in‐solution

Язык: Английский

Процитировано

5

Unlocking New Avenues: Solid-State Synthesis of Molecularly Imprinted Polymers DOI Open Access
Bogdan‐Cezar Iacob, Andreea Bodoki, Diogo Filipe Da Costa Carvalho

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5504 - 5504

Опубликована: Май 18, 2024

Molecularly imprinted polymers (MIPs) are established artificial molecular recognition platforms with tailored selectivity towards a target molecule, whose synthesis and functionality highly influenced by the nature of solvent employed in their synthesis. Steps "greenification" imprinting technology (MIT) has already been initiated elaboration green MIT principles; developing MIPs solvent-free environment may not only offer an eco-friendly alternative, but could also significantly influence affinity expected resulting binding sites. In current study first mechanochemical via liquid-assisted grinding (LAG) is reported. The successful polymer was functionally demonstrated measuring its template rebinding capacity process comparison ones obtained conventional, non-covalent liquid media. results similar capacities molecule superior chemoselectivity compared to solution-based MIP method. adoption chemistry principles all inherent advantages be able alleviate potential environmental health concerns associated analytical (e.g., selective adsorbents) biomedical drug carriers or reservoirs) applications, might conceptual change technology.

Язык: Английский

Процитировано

5

Fast and scalable solvent-free access to Lappert's heavier tetrylenes E{N(SiMe3)2}2 (E = Ge, Sn, Pb) and ECl{N(SiMe3)2} (E = Ge, Sn) DOI Creative Commons
Javier A. Cabeza, Javier F. Reynes, Felipe Garcı́a

и другие.

Chemical Science, Год журнала: 2023, Номер 14(44), С. 12477 - 12483

Опубликована: Янв. 1, 2023

Iconic Lappert's heavier tetrylenes E{N(SiMe3)2}2 (E = Ge (1), Sn (2), Pb (3)) have been efficiently prepared from GeCl2·(1,4-dioxane), SnCl2 or PbCl2 and Li{N(SiMe3)2} via a completely solvent-free one-pot mechanochemical route followed by sublimation. This fast, high-yielding scalable approach (2 has in 100 mmol scale), which involves small environmental footprint, represents remarkable improvement over any synthetic reported the last five decades, being so far rare example of use mechanochemistry realm main group chemistry. solventless successfully extended to preparation other tetrylenes, such as ECl{N(SiMe3)2} (4), (5)).

Язык: Английский

Процитировано

11

Dial-a-base mechanochemical synthesis of N-heterocyclic carbene copper complexes DOI Creative Commons

Dawid J. Babula,

Rex S. C. Charman,

Josie A. Hobson

и другие.

Dalton Transactions, Год журнала: 2024, Номер 53(9), С. 3990 - 3993

Опубликована: Янв. 1, 2024

Ball milling of 5-, 6-, and 7-membered N-heterocyclic carbene (NHC) salts, copper( i ) chloride alkali metal bases including alkoxides, amides, organolithium produces to 12 NHC-copper complexes in moderate good yields.

Язык: Английский

Процитировано

4

Cu(ii)-catalyzed ‘in-water’ N-arylation of electron-deficient NH-heterocycles DOI
Steeva Sunny, Mohit Maingle, Loddipalle Sheeba

и другие.

Green Chemistry, Год журнала: 2024, Номер 26(6), С. 3149 - 3158

Опубликована: Янв. 1, 2024

Cu( ii )-catalyzed robust efficient in-water N -arylation of electron-poor NH-heterocycles is reported. Wide substrate scope, decent yields, functional group tolerance, gram-scale synthesis, synthetic elaboration, late-stage arylation mirror advantages.

Язык: Английский

Процитировано

4

Mechanochemical aerobic oxidative Heck coupling by polymer-assisted grinding: cyclodextrin additive facilitating regioselectivity control DOI
Keyu Xiang, Haowen Shou, Chenhui Hu

и другие.

Green Chemistry, Год журнала: 2024, Номер 26(10), С. 5890 - 5899

Опубликована: Янв. 1, 2024

A novel approach utilizing the polymer-assisted grinding (POLAG) technique to facilitate regioselective oxidative Heck coupling of aryl boronic acids with electronically unbiased olefins under solvent-free conditions was presented.

Язык: Английский

Процитировано

4

Advanced green synthesis: Solvent-free and catalyst-free reaction DOI Creative Commons
Mengyao Li,

Ao Gu,

Jiatong Li

и другие.

Green Synthesis and Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

4