The Pharma Innovation,
Год журнала:
2023,
Номер
12(5), С. 2294 - 2301
Опубликована: Май 1, 2023
Turmeric,
a
widely
recognized
natural
supplement,
has
been
shown
to
have
range
of
health
benefits
due
its
anti-inflammatory
and
antioxidant
properties.
However,
the
bioavailability
turmeric
is
limited
poor
solubility,
rapid
metabolism,
low
absorption
in
gastrointestinal
tract.
Encapsulation
an
innovative
approach
that
can
help
address
these
issues
improve
efficacy
supplements.
This
review
examines
current
research
on
encapsulated
potential
for
improving
effectiveness.
techniques
such
as
liposomes,
solid
lipid
nanoparticles,
nanoemulsions
enhance
by
protecting
active
compounds
from
degradation
their
body.
These
also
found
increase
duration
turmeric's
beneficial
effects.
Nutrition and Diabetes,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 8, 2024
Abstract
Background/objectives
The
present
study
investigated
the
effect
of
curcumin
and
eicosapentaenoic
acid,
as
one
main
components
omega-3
polyunsaturated
fatty
acids,
on
anthropometric,
glucose
homeostasis,
gene
expression
markers
cardio-metabolic
risk
in
patients
with
type
2
diabetes
mellitus.
Subjects/methods
This
clinical
trial
was
conducted
at
Endocrinology
Clinic
Imam
Reza
Hospital
Tabriz.
It
aimed
to
determine
impact
Eicosapentaenoic
Acid
(EPA),
Docosahexaenoic
(DHA),
supplements
various
health
indicators
Type
Diabetes
Mellitus
(DM2)
from
2021.02.01
2022.02.01.
a
randomized
double-blinded
over
12
weeks
100
participants
randomly
divided
into
four
groups.
Stratified
randomization
used
assign
two
months
supplementation
based
sex
Body
Mass
Index
(BMI).
comprised
groups:
Group
1
received
capsules
500
mg
EPA
200
DHA,
along
nano-curcumin
placebo;
capsule
80
omega
3
Fatty
Acids
placebos;
nano-curcumin;
4,
control,
placebos
placebo.
Results
After
twelve
taking
+
Nano-curcumin
supplements,
experienced
statistically
significant
reduction
insulin
levels
their
blood
[MD:
−1.44
(−2.70,
−0.17)].
decrease
significantly
greater
than
changes
observed
placebo
group
−0.63
(−1.97,
0.69)].
also
showed
High-Sensitivity
C-Reactive
Protein
(hs-CRP)
compared
(
p
<
0.05).
Additionally,
had
increase
Total
Antioxidant
Capacity
(TAC)
0.01).
However,
there
were
no
differences
Fasting
Blood
Sugar
(FBS),
Homeostatic
Model
Assessment
Insulin
Resistance
(HOMA-IR)
index,
Quantitative
Sensitivity
Check
(QUICKI),
or
Hemoglobin
A1c
(HbA1C)
between
groups
(all
>
There
−17.02
(−32.99,
−1.05)],
control
−20.76
(−36.73,
−4.79)]
terms
lowering
serum
cholesterol
level.
difference
Triglycerides
(TG)
not
=
0.093).
decreases
Low-Density
Lipoprotein
(LDL)
−20.12
(−36.90,
−3.34)]
−20.79
(−37.57,
−4.01)].
near-to-significant
High-Density
(HDL)
0.056).
Finally,
Vascular
Endothelial
Growth
Factor
(VEGF)
−127.50
(−247.91,
−7.09)],
126.25
(5.83,
246.66)],
−122.76
(−243.17,
−2.35)],
Nano-
121.50
(1.09,
241.92)].
Conclusions
findings
suggest
that
12-week
may
positively
inflammation,
oxidative
stress,
metabolic
parameters
diabetes.
be
potential
intervention
manage
reduce
complications
associated
further
research
is
needed
validate
study’s
establish
long-term
effects
Foods,
Год журнала:
2024,
Номер
13(9), С. 1287 - 1287
Опубликована: Апрель 23, 2024
Parkinson’s
disease
(PD),
the
second
most
common
neurodegenerative
disorder,
is
linked
to
α-synuclein
(α-Syn)
aggregation.
Despite
no
specific
drug
being
available
for
its
treatment,
curcumin,
from
spice
turmeric,
shows
promise.
However,
application
in
PD
limited
by
a
lack
of
understanding
anti-amyloidogenic
mechanisms.
In
this
study,
we
first
reconstructed
liquid–liquid
phase
separation
(LLPS)
α-Syn
vitro
under
different
conditions,
which
may
be
an
initial
step
entraining
pathogenic
Subsequently,
evaluated
effects
curcumin
on
formation
droplets,
oligomers,
and
aggregated
fibers
during
LLPS
α-synuclein,
as
well
impact
toxicity
cultured
cells.
Importantly,
found
that
can
inhibit
amyloid
inhibiting
occurrence
subsequent
oligomers
early
stages
Finally,
molecular
dynamic
simulations
interactions
between
decamer
fibrils
showed
van
der
Waal’s
make
largest
contribution
anti-aggregation
effect
curcumin.
These
results
help
clarify
mechanism
inhibits
aggregates
development
PD.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 13, 2025
Background
The
effects
of
resveratrol
supplementation
on
inflammation
and
oxidative
stress
in
patients
with
type
2
diabetes
mellitus
(T2DM)
were
controversial.
A
meta-analysis
was
performed
to
assess
the
changes
levels
T2DM.
Methods
Relevant
literatures
before
November
6,
2024
screened
through
Web
Science,Embase,the
Cochrane
Library
other
sources
(ClinicalTrials,
ProQuest
Dissertations
Theses).
quality
literature
evaluated
according
Handbook
Systematic
Reviews.
study
assessed
using
risk-of-bias
tool
Grading
Recommendations
Assessment,Development
Evaluation
(GRADE)
system.
Review
Manager
5.3
conducted
data
included
literature.
Results
This
six
randomized
controlled
trials
involving
533
participants.
Our
results
showed
that
significantly
reduced
C-reactive
protein
levels(SMD
=
-1.40,
95%CI(-2.60,
-0.21),
P
0.02;
Level
evidence:
low),
lipid
peroxide
(SMD
-0.99,
95%CI(-1.36,
-0.61),
<
0.00001;
8-isoprostanes(SMD
-0.79,
95%CI(-1.16,
-0.42),
0.0001;
low)
score
-1.62,
95%CI(-2.49,
-0.75),
0.0003;
very
low).
In
addition,
compared
placebo,
Supplementation
increased
glutathione
peroxidase
0.38,
95%CI(0.03,
0.74),
0.04;
evidence:low)
catalase
0.33,
0.63),
0.03;
However,
no
significant
difference
observed
improving
interleukin-6
-1.35,
95%CI(-2.75,
-0.05),
0.06;
tumor
necrosis
factor
α
-3.30,
95%CI(-7.47,
0.87),
0.12;
superoxide
dismutase
0.39,
95%CI(-0.26,
1.04),
0.24;
total
antioxidant
capacity
95%CI(-0.23,
1.00),
0.21;
malondialdehyde
-3.36,
95%CI(-10.30,
3.09),
0.29;
Conclusion
Resveratrol
improved
T2DM
some
extent.
provides
a
new
idea
method
for
clinical
treatment.
due
limitations
study,
more
large-sample,
multi-center
studies
are
needed
verify
this
conclusion.
Journal of physiological investigation.,
Год журнала:
2024,
Номер
67(3), С. 107 - 117
Опубликована: Май 1, 2024
Diabetic
retinopathy
(DR)
is
a
secondary
complication
of
diabetes
that
can
lead
to
visual
impairment
and
blindness.
The
retinal
pigment
epithelium
(RPE)
monolayer
cells
forms
the
blood–retinal
barrier
(BRB)
via
tight
junction
(TJ)
proteins
plays
crucial
role
in
physiological
function
retina.
Hyperglycemia
induces
RPE
death
BRB
breakdown,
which
accelerates
process
DR.
Curcumin,
an
active
extract
Curcuma
longa
,
has
anti-inflammatory,
antioxidant,
antiapoptotic,
neuroprotective
properties.
However,
effect
Curcumin
on
under
high
glucose
conditions
remains
unknown.
This
study
aimed
investigate
protective
effects
physiology
vitro
vivo
.
significantly
alleviated
cell
viability
inhibition
conditions.
Moreover,
reduced
extracellular
signal-regulated
kinase
Akt
pathways
activation
diminish
growth
but
reversed
by
treatment.
protected
not
only
TJ
integrity
also
retinoid
regeneration
through
isomerase
modulation
diabetic
Furthermore,
decreased
expression
angiogenic
factor
inhibit
neovascularization.
Finally,
treatment
markedly
apoptosis
during
hyperglycemia.
In
conclusion,
alleviate
progression
DR
promoting
survival,
integrity,
activity,
senescence
inhibition,
Therefore,
exhibits
potential
for
use
as
therapeutic
agent
early
Health Science Reports,
Год журнала:
2025,
Номер
8(3)
Опубликована: Март 1, 2025
Patients
with
polycystic
ovary
syndrome
(PCOS)
commonly
have
cardiometabolic
risk
factors.
Oxidative
stress
(OS)
significantly
contributes
to
the
development
of
diseases.
Curcumin
(CUR)
exhibits
antioxidant
properties
that
aid
in
OS
regulation.
This
systematic
review
and
dose-response
meta-analysis
randomized
clinical
trials
(RCTs)
evaluated
effects
CUR
supplementation
on
factors
women
PCOS.
A
search
across
various
databases
was
implemented
identify
eligible
RCTs
published
until
January
2024.
conducted
employing
a
random-effects
model.
Eight
were
included
meta-analysis.
It
indicated
substantially
reduced
fasting
blood
sugar
(FBS)
(standardized
mean
difference
[SMD]:
-0.40
mg/dL,
95%
confidence
interval
[CI]:
-0.59,
-0.21;
p
<
0.001),
insulin
(SMD:
-0.32
µU/mL,
CI:
-0.49,
-0.14;
homeostasis
model
assessment
resistance
(HOMA-IR)
-0.36,
-0.54,
-0.19;
total
cholesterol
(TC)
-0.34
-0.61,
-0.08;
=
0.01).
In
addition,
it
increased
quantitative
sensitivity
check
index
(QUICKI)
0.37,
0.13,
0.61;
0.001)
CUR-treated
group
compared
control
group.
However,
did
not
significant
impacts
body
mass
(BMI),
weight,
serum
levels
follicle-stimulating
hormone
(FSH),
triglycerides
(TG),
dehydroepiandrosterone
(DHEA),
high-density
lipoprotein
(HDL),
testosterone,
low-density
(LDL),
luteinizing
(LH).
study
revealed
may
potential
enhance
health
by
reducing
hyperglycemia,
resistance,
TC
Research Journal of Pharmacognosy and Phytochemistry,
Год журнала:
2025,
Номер
unknown, С. 69 - 74
Опубликована: Март 11, 2025
Diabetes
is
a
chronic
metabolic
condition
defined
by
hyperglycemia
caused
abnormalities
in
insulin
secretion,
action,
or
both.
There
an
increasing
interest
investigating
natural
therapy
approaches
to
manage
diabetes
as
the
condition's
incidence
rises
worldwide.
A
considerable
amount
of
attention
has
been
paid
medicinal
plants
because
their
rich
phytochemical
profiles
and
generally
minimal
side-effect
profiles.
The
potential
diverse
managing
explored
this
review
article,
with
particular
emphasis
on
bioactive
compounds—alkaloids,
flavonoids,
terpenoids,
phenolic
acids—that
show
hypoglycemic
effects.
Momordica
charantia
(bitter
melon),
Trigonella
foenum-graecum
(fenugreek),
Gymnema
sylvestre
(gymnema),
Cinnamomum
verum
(cinnamon)
are
among
important
whose
actions
highlighted
due
capacity
increase
improve
sensitivity,
inhibit
breakdown
carbohydrates.
also
emphasizes
how
crucial
it
comprehend
different
phytochemicals
work
concert,
could
provide
more
comprehensive
approach
control
than
single-compound
treatments.
Further
clinical
trials
research
necessary
support
therapeutic
claims,
case
when
discussing
safety,
efficacy,
prospective
incorporation
into
mainstream
diabetic
care.
This
seeks
thorough
overview
function
fight
against
linking
traditional
knowledge
contemporary
scientific
methodologies,
assisting
creation
efficient,
all-natural
antidiabetic
medicines.
Journal of Diabetes Research,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
This
study
explores
the
potential
of
curcumin
(CUR),
extracted
from
Curcuma
longa
,
in
combating
obesity
and
Type
2
diabetes.
Obesity
diabetes
were
induced
rats
through
a
high‐fat
high‐fructose
diet
(HFFD),
CUR,
after
purification
characterization
by
Fourier
transform
infrared
spectroscopy
(FTIR)
ultraviolet
(UV)
spectroscopy,
was
administered
for
3
months
via
gastric
gavage.
The
results
show
that
CUR
supplementation
activates
insulin
signaling
pathway
dose‐dependent
manner,
leading
to
improved
sensitivity.
Specifically,
administering
at
daily
dose
100
mg/kg
significantly
reduces
activities
protein
tyrosine
phosphatase
(PTP1B)
dipeptidyl
peptidase‐4
(DPP‐4)
43%
45%,
respectively,
obese
diabetic
compared
untreated
rats.
Furthermore,
effectively
inhibits
lipase
α
‐amylase
both
serum
intestinal
levels.
In
rats,
administration
glycogen
phosphorylase
(GP)
activity
35%
enhances
synthase
(GS)
78%,
substantial
increase
hepatic
content.
Additionally,
also
led
21%
reduction
food
intake
12%
decrease
water
consumption.
These
changes
contributed
significant
reductions
blood
sugar
glycosylated
hemoglobin
(HbA1c)
levels,
with
decreases
59%
53%,
respectively.
body
weight
reduced
thiobarbituric
acid
reactive
substances
(TBARSs),
hydrogen
peroxide
(H
O
),
total
oxidant
status
(TOS)
49%,
59%,
58%,
demonstrates
strong
regulatory
effect
on
levels
low‐density
lipoprotein
cholesterol
(LDL‐C),
high‐density
(HDL‐C),
(TC).
Overall,
these
underscore
treating
preventing
obesity.
