The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a double-blinded randomized clinical trial

Nutrition and Diabetes, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 8, 2024

Abstract Background/objectives The present study investigated the effect of curcumin and eicosapentaenoic acid, as one main components omega-3 polyunsaturated fatty acids, on anthropometric, glucose homeostasis, gene expression markers cardio-metabolic risk in patients with type 2 diabetes mellitus. Subjects/methods This clinical trial was conducted at Endocrinology Clinic Imam Reza Hospital Tabriz. It aimed to determine impact Eicosapentaenoic Acid (EPA), Docosahexaenoic (DHA), supplements various health indicators Type Diabetes Mellitus (DM2) from 2021.02.01 2022.02.01. a randomized double-blinded over 12 weeks 100 participants randomly divided into four groups. Stratified randomization used assign two months supplementation based sex Body Mass Index (BMI). comprised groups: Group 1 received capsules 500 mg EPA 200 DHA, along nano-curcumin placebo; capsule 80 omega 3 Fatty Acids placebos; nano-curcumin; 4, control, placebos placebo. Results After twelve taking + Nano-curcumin supplements, experienced statistically significant reduction insulin levels their blood [MD: −1.44 (−2.70, −0.17)]. decrease significantly greater than changes observed placebo group −0.63 (−1.97, 0.69)]. also showed High-Sensitivity C-Reactive Protein (hs-CRP) compared ( p < 0.05). Additionally, had increase Total Antioxidant Capacity (TAC) 0.01). However, there were no differences Fasting Blood Sugar (FBS), Homeostatic Model Assessment Insulin Resistance (HOMA-IR) index, Quantitative Sensitivity Check (QUICKI), or Hemoglobin A1c (HbA1C) between groups (all > There −17.02 (−32.99, −1.05)], control −20.76 (−36.73, −4.79)] terms lowering serum cholesterol level. difference Triglycerides (TG) not = 0.093). decreases Low-Density Lipoprotein (LDL) −20.12 (−36.90, −3.34)] −20.79 (−37.57, −4.01)]. near-to-significant High-Density (HDL) 0.056). Finally, Vascular Endothelial Growth Factor (VEGF) −127.50 (−247.91, −7.09)], 126.25 (5.83, 246.66)], −122.76 (−243.17, −2.35)], Nano- 121.50 (1.09, 241.92)]. Conclusions findings suggest that 12-week may positively inflammation, oxidative stress, metabolic parameters diabetes. be potential intervention manage reduce complications associated further research is needed validate study’s establish long-term effects

Language: Английский

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Curcumin Inhibits α-Synuclein Aggregation by Acting on Liquid–Liquid Phase Transition

Foods, Journal Year: 2024, Volume and Issue: 13(9), P. 1287 - 1287

Published: April 23, 2024

Parkinson’s disease (PD), the second most common neurodegenerative disorder, is linked to α-synuclein (α-Syn) aggregation. Despite no specific drug being available for its treatment, curcumin, from spice turmeric, shows promise. However, application in PD limited by a lack of understanding anti-amyloidogenic mechanisms. In this study, we first reconstructed liquid–liquid phase separation (LLPS) α-Syn vitro under different conditions, which may be an initial step entraining pathogenic Subsequently, evaluated effects curcumin on formation droplets, oligomers, and aggregated fibers during LLPS α-synuclein, as well impact toxicity cultured cells. Importantly, found that can inhibit amyloid inhibiting occurrence subsequent oligomers early stages Finally, molecular dynamic simulations interactions between decamer fibrils showed van der Waal’s make largest contribution anti-aggregation effect curcumin. These results help clarify mechanism inhibits aggregates development PD.

Language: Английский

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The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 13, 2025

Background The effects of resveratrol supplementation on inflammation and oxidative stress in patients with type 2 diabetes mellitus (T2DM) were controversial. A meta-analysis was performed to assess the changes levels T2DM. Methods Relevant literatures before November 6, 2024 screened through Web Science,Embase,the Cochrane Library other sources (ClinicalTrials, ProQuest Dissertations Theses). quality literature evaluated according Handbook Systematic Reviews. study assessed using risk-of-bias tool Grading Recommendations Assessment,Development Evaluation (GRADE) system. Review Manager 5.3 conducted data included literature. Results This six randomized controlled trials involving 533 participants. Our results showed that significantly reduced C-reactive protein levels(SMD = -1.40, 95%CI(-2.60, -0.21), P 0.02; Level evidence: low), lipid peroxide (SMD -0.99, 95%CI(-1.36, -0.61), &lt; 0.00001; 8-isoprostanes(SMD -0.79, 95%CI(-1.16, -0.42), 0.0001; low) score -1.62, 95%CI(-2.49, -0.75), 0.0003; very low). In addition, compared placebo, Supplementation increased glutathione peroxidase 0.38, 95%CI(0.03, 0.74), 0.04; evidence:low) catalase 0.33, 0.63), 0.03; However, no significant difference observed improving interleukin-6 -1.35, 95%CI(-2.75, -0.05), 0.06; tumor necrosis factor α -3.30, 95%CI(-7.47, 0.87), 0.12; superoxide dismutase 0.39, 95%CI(-0.26, 1.04), 0.24; total antioxidant capacity 95%CI(-0.23, 1.00), 0.21; malondialdehyde -3.36, 95%CI(-10.30, 3.09), 0.29; Conclusion Resveratrol improved T2DM some extent. provides a new idea method for clinical treatment. due limitations study, more large-sample, multi-center studies are needed verify this conclusion.

Language: Английский

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The Many Facets of PPAR-γ Agonism in Obesity and Associated Comorbidities: Benefits, Risks, Challenges, and Future Directions

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 12, 2025

Language: Английский

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Protective Effect of Curcumin on the Tight Junction Integrity and Cellular Senescence in Human Retinal Pigment Epithelium of Early Diabetic Retinopathy

Journal of physiological investigation., Journal Year: 2024, Volume and Issue: 67(3), P. 107 - 117

Published: May 1, 2024

Diabetic retinopathy (DR) is a secondary complication of diabetes that can lead to visual impairment and blindness. The retinal pigment epithelium (RPE) monolayer cells forms the blood–retinal barrier (BRB) via tight junction (TJ) proteins plays crucial role in physiological function retina. Hyperglycemia induces RPE death BRB breakdown, which accelerates process DR. Curcumin, an active extract Curcuma longa , has anti-inflammatory, antioxidant, antiapoptotic, neuroprotective properties. However, effect Curcumin on under high glucose conditions remains unknown. This study aimed investigate protective effects physiology vitro vivo . significantly alleviated cell viability inhibition conditions. Moreover, reduced extracellular signal-regulated kinase Akt pathways activation diminish growth but reversed by treatment. protected not only TJ integrity also retinoid regeneration through isomerase modulation diabetic Furthermore, decreased expression angiogenic factor inhibit neovascularization. Finally, treatment markedly apoptosis during hyperglycemia. In conclusion, alleviate progression DR promoting survival, integrity, activity, senescence inhibition, Therefore, exhibits potential for use as therapeutic agent early

Language: Английский

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Tinglu Yixin granule inhibited fibroblast-myofibroblast transdifferentiation to ameliorate myocardial fibrosis in diabetic mice

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118980 - 118980

Published: Oct. 1, 2024

Language: Английский

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Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose−Response Meta‐Analysis

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(3)

Published: March 1, 2025

Patients with polycystic ovary syndrome (PCOS) commonly have cardiometabolic risk factors. Oxidative stress (OS) significantly contributes to the development of diseases. Curcumin (CUR) exhibits antioxidant properties that aid in OS regulation. This systematic review and dose-response meta-analysis randomized clinical trials (RCTs) evaluated effects CUR supplementation on factors women PCOS. A search across various databases was implemented identify eligible RCTs published until January 2024. conducted employing a random-effects model. Eight were included meta-analysis. It indicated substantially reduced fasting blood sugar (FBS) (standardized mean difference [SMD]: -0.40 mg/dL, 95% confidence interval [CI]: -0.59, -0.21; p < 0.001), insulin (SMD: -0.32 µU/mL, CI: -0.49, -0.14; homeostasis model assessment resistance (HOMA-IR) -0.36, -0.54, -0.19; total cholesterol (TC) -0.34 -0.61, -0.08; = 0.01). In addition, it increased quantitative sensitivity check index (QUICKI) 0.37, 0.13, 0.61; 0.001) CUR-treated group compared control group. However, did not significant impacts body mass (BMI), weight, serum levels follicle-stimulating hormone (FSH), triglycerides (TG), dehydroepiandrosterone (DHEA), high-density lipoprotein (HDL), testosterone, low-density (LDL), luteinizing (LH). study revealed may potential enhance health by reducing hyperglycemia, resistance, TC

Language: Английский

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Nature’s Pharmacy: Plants with Potential in Diabetes Management

Research Journal of Pharmacognosy and Phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 69 - 74

Published: March 11, 2025

Diabetes is a chronic metabolic condition defined by hyperglycemia caused abnormalities in insulin secretion, action, or both. There an increasing interest investigating natural therapy approaches to manage diabetes as the condition's incidence rises worldwide. A considerable amount of attention has been paid medicinal plants because their rich phytochemical profiles and generally minimal side-effect profiles. The potential diverse managing explored this review article, with particular emphasis on bioactive compounds—alkaloids, flavonoids, terpenoids, phenolic acids—that show hypoglycemic effects. Momordica charantia (bitter melon), Trigonella foenum-graecum (fenugreek), Gymnema sylvestre (gymnema), Cinnamomum verum (cinnamon) are among important whose actions highlighted due capacity increase improve sensitivity, inhibit breakdown carbohydrates. also emphasizes how crucial it comprehend different phytochemicals work concert, could provide more comprehensive approach control than single-compound treatments. Further clinical trials research necessary support therapeutic claims, case when discussing safety, efficacy, prospective incorporation into mainstream diabetic care. This seeks thorough overview function fight against linking traditional knowledge contemporary scientific methodologies, assisting creation efficient, all-natural antidiabetic medicines.

Language: Английский

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Protective Effects of Isolated Curcumin From Curcuma longa on Key Enzymes Involved in the Insulin Signaling Pathway and Digestive and Metabolic Enzymes Associated With Obesity, Type 2 Diabetes, and Hypertension

Journal of Diabetes Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

This study explores the potential of curcumin (CUR), extracted from Curcuma longa , in combating obesity and Type 2 diabetes. Obesity diabetes were induced rats through a high‐fat high‐fructose diet (HFFD), CUR, after purification characterization by Fourier transform infrared spectroscopy (FTIR) ultraviolet (UV) spectroscopy, was administered for 3 months via gastric gavage. The results show that CUR supplementation activates insulin signaling pathway dose‐dependent manner, leading to improved sensitivity. Specifically, administering at daily dose 100 mg/kg significantly reduces activities protein tyrosine phosphatase (PTP1B) dipeptidyl peptidase‐4 (DPP‐4) 43% 45%, respectively, obese diabetic compared untreated rats. Furthermore, effectively inhibits lipase α ‐amylase both serum intestinal levels. In rats, administration glycogen phosphorylase (GP) activity 35% enhances synthase (GS) 78%, substantial increase hepatic content. Additionally, also led 21% reduction food intake 12% decrease water consumption. These changes contributed significant reductions blood sugar glycosylated hemoglobin (HbA1c) levels, with decreases 59% 53%, respectively. body weight reduced thiobarbituric acid reactive substances (TBARSs), hydrogen peroxide (H O ), total oxidant status (TOS) 49%, 59%, 58%, demonstrates strong regulatory effect on levels low‐density lipoprotein cholesterol (LDL‐C), high‐density (HDL‐C), (TC). Overall, these underscore treating preventing obesity.

Language: Английский

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Unleashing the Positive Impact of Natural Bioactive Compounds in the Therapeutic Strategy for Metabolic Syndrome

Published: Jan. 1, 2025

Language: Английский

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