Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(11)
Опубликована: Сен. 18, 2023
Abstract
An
eco‐friendly
and
efficient
synthesis
of
pyridazin‐3(2
H
)‐ones
from
aromatic
sulfonyl
hydrazides
mucohalic
acids
has
been
developed.
This
facile
strategy
is
carried
out
smoothly
via
the
promotion
simple
organic
acid
p
‐toluenesulfonic
acid,
able
to
form
two
C−N
bonds
a
heterocycle
linking
potentially
bioactive
group
at
one‐step.
The
protocol
tolerant
various
readily
available
substrates
in
good
yields,
as
desired
products
are
key
structural
fragments
many
compounds.
More
importantly,
gram‐scale
cyclization
reaction
novel
approach
derivatives
successfully
reveals
its
practicability.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(7), С. 4334 - 4344
Опубликована: Март 16, 2023
An
inexpensive
electrochemical
induction
system
was
used
for
the
efficient
reductive
defunctionalization
of
sulfoximines
through
a
radical
pathway.
This
practical
and
robust
strategy
could
be
removal
S═N
bond-directing
group
from
various
sulfoximines.
The
practicability
this
method
demonstrated
by
its
mild
conditions,
simple
operation,
one-pot
procedure,
gram-scale
synthesis,
undivided
cell.
Furthermore,
preliminary
mechanistic
studies
suggested
that
reaction
might
proceed
via
homocoupling
denitrification
procedure.
Chemical Communications,
Год журнала:
2023,
Номер
59(81), С. 12164 - 12167
Опубликована: Янв. 1, 2023
An
electrooxidation
direct
difunctionalization
of
alkynes
with
sulfonyl
hydrazides
has
been
developed
for
the
construction
alkenyl
sulfates
in
absence
metal
catalysts
and
a
stoichiometric
amount
oxidants.
Notably,
it
is
first
example
to
verify
that
SO42-
ions
can
act
as
nucleophilic
reagent
preparation
organosulfates.
Beilstein Journal of Organic Chemistry,
Год журнала:
2023,
Номер
19, С. 800 - 807
Опубликована: Июнь 9, 2023
Quinoline-based
sulfonyl
derivatives,
and
especially
sulfonamides,
are
relevant
promising
structures
for
drug
design.
We
have
developed
a
new
convenient
protocol
the
synthesis
of
3-sulfonyl-substituted
quinolines
(sulfonamides
sulfones).
The
approach
is
based
on
Knoevenagel
condensation/aza-Wittig
reaction
cascade
involving
o-azidobenzaldehydes
ketosulfonamides
or
ketosulfones
as
key
building
blocks.
appropriate
both
ketosulfonyl
reagents
α-sulfonyl-substituted
alkyl
acetates
providing
target
quinoline
derivatives
in
good
to
excellent
yields.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
22(3), С. 513 - 520
Опубликована: Дек. 18, 2023
A
photoredox
radical
cascade
cyclization
reaction
for
the
effective
construction
of
2,4-disubstituted
quinolines
at
room
temperature
is
described.
It
shows
good
substrate
suitability
and
functional
group
compatibility.
Organic Letters,
Год журнала:
2024,
Номер
26(44), С. 9547 - 9552
Опубликована: Окт. 25, 2024
α,β-Dehydrogenation
of
flavanones
represents
an
ideal
strategy
to
synthesize
various
flavones
but
remains
challenging
because
the
requirements
for
rigorous
conditions.
Herein,
a
straightforward
and
efficient
route
synthesis
via
electrocatalysis
is
disclosed.
This
electro-oxidative
approach
shows
broad
substrate
scope,
including
azaflavanones
thioflavanones,
which
could
be
performed
in
undivided
cell
without
removal
air
or
water
absence
metal
catalysts,
ligands,
external
oxidants.
Moreover,
combination
cyclic
voltammetry,
square
wave
voltammetry
experiments,
density
functional
theory
(DFT)
calculations
revealed
plausible
mechanism.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(11)
Опубликована: Сен. 18, 2023
Abstract
An
eco‐friendly
and
efficient
synthesis
of
pyridazin‐3(2
H
)‐ones
from
aromatic
sulfonyl
hydrazides
mucohalic
acids
has
been
developed.
This
facile
strategy
is
carried
out
smoothly
via
the
promotion
simple
organic
acid
p
‐toluenesulfonic
acid,
able
to
form
two
C−N
bonds
a
heterocycle
linking
potentially
bioactive
group
at
one‐step.
The
protocol
tolerant
various
readily
available
substrates
in
good
yields,
as
desired
products
are
key
structural
fragments
many
compounds.
More
importantly,
gram‐scale
cyclization
reaction
novel
approach
derivatives
successfully
reveals
its
practicability.
