An electrochemical cascade process: synthesis of 3-selenylindoles from 2-alkynylanilines with diselenides
Chemical Communications,
Год журнала:
2023,
Номер
59(56), С. 8719 - 8722
Опубликована: Янв. 1, 2023
Substituted
organoselenium
compounds
are
crucial
structural
motifs
in
pharmaceutical
molecules.
Herein,
we
report
a
metal,
oxidant,
and
base-free
electrochemical
approach
to
access
3-selenylindoles
through
an
oxidative
cyclization
of
2-alkynylanilines
with
diselenides.
This
environmentally
friendly
demonstrates
wide
range
substrate
scope
under
mild
reaction
conditions
undivided
cell
setup.
Язык: Английский
Electrochemical selenofunctionalization of unactivated alkenes: access to β-hydroxy-selenides
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(9), С. 1775 - 1781
Опубликована: Янв. 1, 2024
This
work
demonstrates
the
electrochemical
construction
of
2-methyl-1-aryloxy-3-(arylselanyl)propan-2-ol/2-hydroxy-2-methyl-3-(arylselanyl)propyl
2-(2-hydroxy-2-methyl-3-(arylselanyl)propoxy)benzoate
starting
from
aryl
allyl
ethers/allyl
benzoates
and
diaryl
diselenides
under
additive-free
conditions.
environmentally
friendly
method
was
achieved
through
constant
current
electrolysis
in
an
undivided
cell
setup
acid,
oxidant,
or
catalyst-free
Additionally,
this
technique
enabled
synthesis
a
variety
β-hydroxy
selenides
including
late-stage
functionalization
drug
derivatives
good
to
exceptional
yields
across
various
substrates
mild
reaction
Язык: Английский
Research Advances in Electrochemical Synthesis of Spirocyclic Skeleton Compounds
Synthesis,
Год журнала:
2023,
Номер
55(18), С. 2873 - 2895
Опубликована: Янв. 24, 2023
Abstract
Spirocyclic
compounds
have
attracted
the
interest
of
synthetic
chemists
because
their
unique
ring
systems
and
utility
in
drug
discovery.
Many
natural
containing
spirocyclic
moieties
skeleton
are
effective
pharmaceuticals.
For
many
redox
processes,
electroorganic
synthesis
is
considered
an
environmentally
friendly
method,
since
use
reagents
with
significant
toxicity
replaced
by
electric
current,
so
amount
waste
often
greatly
reduced.
Therefore,
this
review
summarizes
construction
a
via
electrochemical
strategies
2000.
1
Introduction
2
Electrochemically
Mediated
Synthesis
Spirocyclopropanes
3
Spirooxindoles
4
Spirodienones
5
Other
Heterospirocycles
6
Conclusion
Язык: Английский
Electrochemical cascade sequences for remote C7–H bond thiocyanation of quinoxalin-2(1H)-ones with ammonium thiocyanate
Green Chemistry,
Год журнала:
2023,
Номер
25(19), С. 7774 - 7781
Опубликована: Янв. 1, 2023
Electrochemical
cascade
sequences
for
regioselective
direct
C7-thiocyanation
of
quinoxalin-2(1
H
)-ones
with
ammonium
thiocyanate
have
been
developed.
Язык: Английский
Electrochemical cascade reactions: an account of recent developments for this modern strategic tool in the arsenal of chemical synthesis
Green Chemistry,
Год журнала:
2023,
Номер
25(24), С. 10144 - 10181
Опубликована: Янв. 1, 2023
The
electrochemical
cascade
process
majorly
satisfies
the
essential
criteria
of
green
synthesis.
Being
an
Integrated
synthetic
strategy
it
can
produce
more
molecules
in
a
shorter
time
and
thus
provides
modern
strategic
tool
arsenal
chemists.
Язык: Английский
Electro-Oxidative Synthesis of Phenazines
Organic Letters,
Год журнала:
2023,
Номер
25(20), С. 3772 - 3777
Опубликована: Май 15, 2023
We
disclose
herein
electro-oxidative
synthesis
as
the
general
protocol
for
procuring
phenazines
under
mild
reaction
conditions.
Using
aerial
oxygen
an
oxidant,
inexpensive
electrolyte,
and
electrodes,
a
diverse
range
of
have
been
accessed
in
good
yields
via
ring
contraction
10,11-dihydro-5H-dibenzo[b,e][1,4]diazepines.
In
addition,
syntheses
diamino
direct
electro-oxidation
dihydrophenazines
electro-dimerization
o-phenylenediamines,
respectively,
also
accomplished.
Язык: Английский
Electrochemical Annulation of ortho‐Alkynylbiphenyls to Fused Sulfenyl Phenanthrenes and Spiro Cyclohexenone Indenes
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
366(1), С. 18 - 23
Опубликована: Ноя. 21, 2023
Abstract
Here,
we
present
an
electrochemically
induced
synthesis
of
9‐sulfenylarylphenanthrenes
and
3’‐sulfenylarylspiro‐cyclohexa[4.5]trienones
starting
from
o
‐alkynylbiphenyls
diaryl
disulfides.
This
method
was
accomplished
through
constant
current
electrolysis
10
mA
in
undivided
cell
setup
by
utilizing
CH
3
CN
as
a
solvent
LiClO
4
electrolyte
at
room
temperature.
Notably,
the
strategy
enabled
formation
sulfenylphenanthrenes
sulfenyl
spiro
cyclohexa[4.5]trienones
70%–95%
yield.
Scale‐up
synthesis,
mechanistic
studies,
cyclic
voltammetry
have
also
been
carried
out.
Язык: Английский
Electrochemical Oxidative Thiocyanosulfonylation of Aryl Acetylenes
Chinese Journal of Organic Chemistry,
Год журнала:
2022,
Номер
42(12), С. 4275 - 4275
Опубликована: Янв. 1, 2022
Thiocyano
and
sulfonyl
groups
as
important
functional
are
widely
existing
in
natural
products,
agrochemicals
medicines.They
also
versatile
synthetic
intermediates
that
could
be
converted
into
various
functionalities.There
limited
reports
on
the
synthesis
of
compounds
contain
these
two
groups.A
simple
three-component
thiocyanatosulfonylation
aryl
acetylenes
with
sodium
sulfinates
NH4SCN
through
electrochemical
oxidation
to
construct
thiocyanated
vinylsulfones
has
been
established.The
reaction
employs
easily
accessible
starting
materials
features
characterization
external
oxidant-free,
mild
conditions,
high
stereoselectivity.Moreover,
this
method
enables
C-S
bonds
simultaneously
formed
a
one-step
reaction.
Язык: Английский