The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(21), С. 15914 - 15923
Опубликована: Окт. 23, 2024
A
novel
selenized
reaction
of
N-arylbicyclo
[1.1.0]butane-1-carboxamides
with
diselenide
for
the
synthesis
polycyclic
indoline
derivatives
is
developed
under
electrochemical
conditions.
The
achieved
by
bicyclo[1.1.0]butane
strain-release
and
intramolecular
cyclization
process.
In
addition,
this
approach
features
a
wide
range
substrates,
good
group
tolerance,
shorter
time,
mild
Abstract
In
2014,
the
World
Health
Organization
called
drug
resistance
to
antibiotics
a
“major
global
threat”.
Therefore,
ever‐increasing
human
need
for
new
with
greater
effectiveness
and
fewer
side
effects
is
necessity.
Meanwhile,
sulfonamides
are
among
most
widely
used
in
world.
this
review,
attention
has
been
paid
key
points
raised
various
papers
field
of
electrosynthesis
these
compounds,
considering
their
positive
negative
aspects,
including
interaction
as
much
possible
principles
green
chemistry
absence
environmental
risks,
low
cost
versatility
scalability
method
along
acceptable
efficiency.
following,
we
will
discuss
research
focused
on
synthesis
sulfonamide
derivatives
based
oxidation
or
reduction
compounds
which
take
place
working
electrode
surface.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
27(4)
Опубликована: Дек. 6, 2023
Abstract
Isatin,
also
known
as
indoline‐2,3‐dione,
is
a
fused,
N
‐heterocyclic
aromatic
compound
first
isolated
and
purified
in
1841.
Since
then,
isatin
its
derivatives
emerged
hot
research
topic
for
the
scientific
community.
The
number
of
publications
on
justifies
their
popularity.
Researchers
explored
isatins
potential
candidates
multidisciplinary
areas,
including
medicinal
chemistry,
synthetic
organic
polymer
science.
Synthetic
chemists’
perspective
tailoring
family
members
led
to
more
efficient
synthesis
strategies
which
ring‐opening
reactions
were
particularly
significant
due
product's
importance.
Our
investigation
aims
group
different
types
cascade
ring
expansion
synthesise
fused
heterocyclic
compounds
such
quinolines,
quinazolinones,
acridines,
acridones,
few
spiro
compounds,
all
highlight
an
inevitable
role
field
chemistry.
Chinese Journal of Organic Chemistry,
Год журнала:
2023,
Номер
43(9), С. 3006 - 3006
Опубликована: Янв. 1, 2023
As
one
of
the
most
important
structural
motifs
in
natural
compounds
and
active
pharmaceutical
ingredients,
azaspiro[4.5]trienonesderivatives
have
been
widely
used
field
organic
synthesis
due
to
their
excellent
properties
biological
activities.In
recent
years,
several
methods,
such
as
transition
metal
involvement,
visible
light
promotion,
metal-free
involvement
electrochemical
efficiently
construct
various
functional
groups
azaspiro[4.5]trienones.The
advances
azaspiro[4.5]trienones
are
reviewed,
representative
substrates
reaction
mechanisms
summarized
discussed.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
89(1), С. 425 - 432
Опубликована: Дек. 12, 2023
Spirobenzofuran
scaffolds,
because
of
their
three-dimensional
structure,
are
incorporated
into
several
valuable
natural
products
and
drug
candidate
molecules.
Herein,
with
the
assistance
electrosynthesis,
we
introduce
a
novel
electrochemical
approach
for
achieving
spirobenzofurans
in
user-friendly
operationally
simple
undivided
cell
setup
under
constant
current.
This
metal-catalyst-free
procedure
afforded
spiro[benzofuran-2,2′-furan]-3-ones
high
diastereoselectivity.
Compatibility
gram-scale
synthesis
along
convenient
accessibility
reaction
instruments
starting
materials
collectively
raised
importance
this
protocol
compared
to
previous
challenging
methods.
Furthermore,
mechanistic
cognizance
is
obtained
by
investigation
cyclic
voltammetry
spectra
reactants.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(17), С. 11959 - 11974
Опубликована: Авг. 27, 2024
Divergent
synthesis
of
structurally
different
products
from
the
same
kinds
starting
materials
is
highly
synthetically
useful
but
very
challenging.
Herein,
we
reported
a
base-mediated
chemodivergent
[4
+
1]
and
[2
cycloaddition
N-alkylpyridinium
enone
under
mild
conditions,
leading
to
furan-fused
bicycles
with
high
diastereoselectivity
spirobicycles,
respectively,
moderate
yields.
N-Alkylpyridinium
salts
were
modular
nucleophilic
transfer
reagents
C1
synthons,
which
underwent
tandem
Michael
addition
α,β-unsaturated
ketones
cyclization
base
conditions.
Late-stage
derivatization
4-propyldicyclohexylanone
an
important
industrial
raw
liquid
crystal
display
(LCD)
screens
was
realized.
In
vitro,
compound
3f
exhibited
good
activities
against
human
colon
cancer
cells
(HCT116)
IC50
values
in
9.82
±
0.27
μM.
Further
biological
evaluations
investigated
mechanism
effective
inhibition
cell
growth,
including
apoptosis
ratio
detection,
cycle
analysis,
migration
capacity
HCT116
cells.
effect
studies,
complex
increased
percentage
apoptotic
26.8%
(15
μM).
Synthesis,
Год журнала:
2024,
Номер
57(02), С. 275 - 295
Опубликована: Авг. 28, 2024
Abstract
The
utilization
of
sulfur
heterocycles
in
organic
synthesis
has
attracted
significant
attention
due
to
their
wide-ranging
applications.
This
review
showcases
the
syntheses
diverse
embedded
with
amino
acid
derivatives,
polycycles,
spirocycles,
cyclophanes,
and
other
complex
scaffolds.
reported
methods
extend
beyond
compound
highlight
use
different
reagents
for
constructing
heterocycles.
Review
also
discusses
utility
a
variety
sulfur-containing
starting
materials
generation
target
molecules.
1
Introduction
2
Potassium
Thioacetate
3
Thiazolidine-2,4-dione
4
Rhodanines
5
Sodium
Sulfide
6
Thiotetronic
Acid
7
Thiadiazoles
8
Thiophene
9
Rongalite
10
Sulfur
Dioxide
11
Divinyl
Sulfone
12
Heterocycles
Based
on
Boronic
Acids
13
Miscellaneous
14
Summary
