Green metrics in mechanochemistry

Chemical Society Reviews, Год журнала: 2023, Номер 52(19), С. 6680 - 6714

Опубликована: Янв. 1, 2023

The quantitative assessment of the greenness mechanochemical processes for green metrics were calculated is herein reported. A general introduction to topic, variables influencing reaction outcome and, an outlook are also provided.

Язык: Английский

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Selective Radical Transformations with Aryldiazonium Salts

European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(12)

Опубликована: Фев. 15, 2023

Abstract This review provides an overview of the use aryldiazonium salts as source aryl radicals and their application in development selective transformations over last 13 years. Examples were organized under thermal photocatalytic transformations. accessible follow‐up this field for both radical catalytic chemists working industry well academia.

Язык: Английский

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C-4 Regioselective Alkylation of Pyridines Driven by Mechanochemically Activated Magnesium Metal

Organic Letters, Год журнала: 2023, Номер 25(14), С. 2531 - 2536

Опубликована: Апрель 5, 2023

Mechanochemically activated magnesium(0) metal as a highly active mediator driving direct C-4–H alkylation of pyridines with alkyl halides has been developed. Excellent regioselectivity and substrate scope, including those containing reducible functionalities, free amines, alcohols, well biologically relevant molecules were achieved to access 4-alkylpyridine products. Preliminary mechanistic studies suggested radical–radical coupling pathway.

Язык: Английский

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Organic Reactions Enabled by Mechanical Force‐Induced Single Electron Transfer

Chemistry - A European Journal, Год журнала: 2024, Номер 30(47)

Опубликована: Июнь 18, 2024

Mechanochemical reactions, achieved through milling, grinding, or other mechanical actions, have emerged as a solvent-free alternative to traditional solution-based chemistry. Mechanochemistry not only provides the opportunity eliminate bulk solvent use, reducing waste generation, but also unveils new reaction strategy which enables realization of reactions previously inaccessible in solution. While majority organic facilitated by force traditionally follow two-electron transfer pathways similar their counterparts, field mechanochemically induced single-electron (SET) has witnessed rapid development. This review outlines examples mechanochemical SET process, focusing on reagents that initiate SET, thereby positioning mechanochemistry burgeoning within realm

Язык: Английский

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Mechanochemical Synthesis of α‐halo Alkylboronic Esters

Advanced Science, Год журнала: 2024, Номер 11(33)

Опубликована: Июль 3, 2024

α-halo alkylboronic esters, acting as ambiphilic synthons, play a pivotal role versatile intermediates in fields like pharmaceutical science and organic chemistry. The sequential transformation of carbon-boron carbon-halogen bonds into broad range carbon-X allows for programmable bond formation, facilitating the incorporation multiple substituents at single position streamlining synthesis complex molecules. Nevertheless, synthetic potential these compounds is constrained by limited reaction patterns. Additionally, conventional methods often necessitate use bulk toxic solvents, exhibit sensitivity to air/moisture, rely on expensive metal catalysts, involve extended times. In this report, ball milling technique introduced that overcomes limitations, enabling external catalyst-free multicomponent coupling aryl diazonium salts, alkenes, simple halides. This approach offers general straightforward method obtaining diverse array thereby paving way extensive utilization synthons fine chemicals.

Язык: Английский

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Mechanochemical aerobic oxidative Heck coupling by polymer-assisted grinding: cyclodextrin additive facilitating regioselectivity control

Green Chemistry, Год журнала: 2024, Номер 26(10), С. 5890 - 5899

Опубликована: Янв. 1, 2024

A novel approach utilizing the polymer-assisted grinding (POLAG) technique to facilitate regioselective oxidative Heck coupling of aryl boronic acids with electronically unbiased olefins under solvent-free conditions was presented.

Язык: Английский

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A Review on Piezoelectric-mediated Mechanoredox Reactions by Ball Milling in Organic Synthesis

Current Organic Chemistry, Год журнала: 2024, Номер 28(12), С. 905 - 913

Опубликована: Май 6, 2024

Abstract: Recently, the concept of mechanoredox chemistry has been proposed and welldeveloped in organic synthesis. Mechanoredox is conceptually similar to a photocatalyst reaction system, where piezoelectric materials are introduced system manner analogous photoredox catalysis. These reactions feature ability generate high-value radicals that do not require harsh conditions anhydrous anaerobic conditions, an expensive photocatalyst, use solvents, which renders these transformations highly industrially applicable. In addition, also emerging interdisciplinary research field combines material with synthetic create more useful reactions. This review provides comprehensive summary progress date specific transformation related mechanisms piezoelectric- mediated by ball milling

Язык: Английский

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Description of method

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 15 - 51

Опубликована: Янв. 1, 2025

Язык: Английский

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α-C–H functionalization of glycine derivatives under mechanochemical accelerated aging en route the synthesis of 1,4-dihydropyridines and α-substituted glycine esters

Green Chemistry, Год журнала: 2023, Номер 25(7), С. 2853 - 2862

Опубликована: Янв. 1, 2023

A novel accelerated aging cross dehydrogenative coupling of glycine esters/amides and various nucleophiles under metal-free solvent-minimal conditions was developed, providing a sustainable strategy to the synthesis 1,4-DHP α-substituted derivatives.

Язык: Английский

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Mechanochemically Induced Thianthrenium Salts-Based Arylation of Diverse Heterocyclic Scaffolds

ACS Sustainable Chemistry & Engineering, Год журнала: 2024, Номер 12(34), С. 12808 - 12818

Опубликована: Авг. 15, 2024

Herein, a mechanochemically triggered C–H arylation of coumarins, quinoline-N-oxides, and uracil molecules with aryl thianthrenium salts is described. Aryl are primarily acknowledged for their expedient reusability adherence to atom economy principles. Mechanistic studies suggested that mechanical stress promoted the homolytic scission C–S bond salts, forming radical intermediate. Later, intermediate engaged in addition reaction above heterocycles, leading desired products good yields. This versatile protocol accommodates wide range functional groups facilitates synthesis bioactive compounds drug molecules.

Язык: Английский

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