ACS Infectious Diseases,
Год журнала:
2024,
Номер
10(8), С. 2485 - 2506
Опубликована: Июль 13, 2024
Leishmaniasis,
a
critical
Neglected
Tropical
Disease
caused
by
Leishmania
protozoa,
represents
significant
global
health
risk,
particularly
in
resource-limited
regions.
Conventional
treatments
are
effective
but
suffer
from
serious
limitations,
such
as
toxicity,
prolonged
treatment
courses,
and
rising
drug
resistance.
Herein,
we
highlight
the
potential
of
inorganic
nanomaterials
an
innovative
approach
to
enhance
Leishmaniasis
therapy,
aligning
with
One
Health
concept
considering
these
treatments'
environmental,
veterinary,
public
impacts.
By
leveraging
adjustable
properties
nanomaterials─including
size,
shape,
surface
charge,
tailored
for
various
diseases
can
be
developed
that
less
harmful
environment
nontarget
species.
We
review
recent
advances
metal-,
oxide-,
carbon-based
combating
examining
their
mechanisms
action
dual
use
standalone
or
delivery
systems.
Our
analysis
highlights
promising
yet
underexplored
frontier
employing
materials
more
holistic
disease
management.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 868 - 868
Опубликована: Март 7, 2023
The
new
era
of
nanomedicine
offers
significant
opportunities
for
cancer
diagnostics
and
treatment.
Magnetic
nanoplatforms
could
be
highly
effective
tools
diagnosis
treatment
in
the
future.
Due
to
their
tunable
morphologies
superior
properties,
multifunctional
magnetic
nanomaterials
hybrid
nanostructures
can
designed
as
specific
carriers
drugs,
imaging
agents,
theranostics.
Multifunctional
are
promising
theranostic
agents
due
ability
diagnose
combine
therapies.
This
review
provides
a
comprehensive
overview
development
advanced
combining
optical
providing
photoresponsive
platforms
medical
applications.
Moreover,
this
discusses
various
innovative
developments
using
nanostructures,
including
drug
delivery,
treatment,
tumor-specific
ligands
that
deliver
chemotherapeutics
or
hormonal
resonance
imaging,
tissue
engineering.
Additionally,
artificial
intelligence
(AI)
used
optimize
material
properties
based
on
predicted
interactions
with
cell
membranes,
vasculature,
biological
fluid,
immune
system
enhance
effectiveness
therapeutic
agents.
Furthermore,
an
AI
approaches
assess
practical
utility
Finally,
presents
current
knowledge
perspectives
systems
models.
Applied Sciences,
Год журнала:
2024,
Номер
14(4), С. 1623 - 1623
Опубликована: Фев. 17, 2024
In
recent
years,
the
use
of
magnetic
nanoparticles
(MNPs)
in
biomedical
applications
has
gained
more
and
attention.
Their
unusual
properties
make
them
ideal
candidates
for
advancement
diagnosis,
therapy,
imaging
applications.
This
review
addresses
MNPs
field
biomedicine
encompassing
their
synthesis,
biofunctionalization,
unique
physicochemical
that
such
The
synthesis
involves
a
range
techniques
allow
control
over
particle
size,
shape,
surface
modifications.
most
commonly
used
play
crucial
role
tailoring
are
summarized
this
review.
Nevertheless,
main
characterization
can
be
employed
after
successful
procedure
also
included
together
with
short
description
As
is
rapidly
evolving,
aims
to
serve
as
valuable
resource,
especially
young
researchers
medical
professionals,
offering
basic
but
very
useful
insights
into
advancements
future
prospects
highly
interdisciplinary
research
topic.
Abstract
Biomaterials
play
a
vital
role
in
targeting
therapeutics.
Over
the
years,
several
biomaterials
have
gained
wide
attention
treatment
and
diagnosis
of
diseases.
Scientists
are
trying
to
make
more
personalized
treatments
for
different
diseases,
as
well
discovering
novel
single
agents
that
can
be
used
prognosis,
medication
administration,
keeping
track
how
works.
Theranostics
based
on
nano-biomaterials
higher
sensitivity
specificity
disease
management
than
conventional
techniques.
This
review
provides
concise
overview
various
biomaterials,
including
carbon-based
materials
like
fullerenes,
graphene,
carbon
nanotubes
(CNTs),
nanofibers,
their
involvement
theranostics
In
addition,
imaging
techniques
applications
was
overviewed.
is
an
emerging
strategy
has
great
potential
enhancing
accuracy
efficacy
medicinal
interventions.
Despite
presence
obstacles
such
heterogeneity,
toxicity,
reproducibility,
uniformity,
upscaling
production,
regulatory
hurdles,
field
medical
research
development
promise
due
its
ability
provide
patients
with
personalised
care,
facilitate
early
identification,
enable
focused
treatment.
The Journal of Physical Chemistry B,
Год журнала:
2024,
Номер
128(3), С. 781 - 794
Опубликована: Янв. 12, 2024
Magnetite
nanoparticles
(MNPs)
are
attractive
nanomaterials
for
applications
in
magnetic
resonance
imaging,
targeted
drug
delivery,
and
anticancer
therapy
due
to
their
unique
properties
such
as
nontoxicity,
wide
chemical
affinity,
intrinsic
superparamagnetism.
Their
functionalization
with
polymers
chitosan
or
poly(vinyl
alcohol)
(PVA)
can
not
only
improve
biocompatibility
biodegradability
but
it
also
plays
an
important
role
interactions
biological
cells.
In
this
work,
the
effect
of
MNPs
chitosan,
PVA,
blend
on
model
cell
membranes
formed
from
1,2-dipalmitoyl-sn-glycerol-3-phosphocholine
(DPPC)
using
a
Langmuir
technique
was
studied.
The
studies
performed
showed
that
type
biocompatible
polymer
MNP
shell
crucial
effectiveness
its
adsorption
process
into
membrane.
Modification
facilitates
significantly
more
effective
than
coating
them
PVA
blend.
presence
all
investigated
DPPC
monolayer
at
low
concentrations
does
affect
thermodynamic
state,
fluidity,
morphology,
which
is
promising
terms
biocompatibility.
On
other
hand,
high
concentration
(molar
fraction
above
≈0.05)
exerts
disruptive
membrane
results
aggregation,
leading
probably
loss
superparamagnetic
essential
nanomedicine.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(13), С. 10875 - 10875
Опубликована: Июнь 29, 2023
The
rapid
rise
in
research
and
development
following
the
discovery
of
photodynamic
therapy
to
establish
novel
photosensitizers
overcome
limitations
technology
soon
after
its
clinical
translation
has
given
a
few
significant
milestones.
These
include
several
generations
photosensitizers,
widening
scope
applications,
leveraging
offerings
nanotechnology
for
greater
efficacy,
selectivity
disease
over
host
tissue
cells,
advent
combination
therapies
with
other
similarly
minimally
invasive
therapeutic
technologies,
use
stimulus-responsive
delivery
targeting,
penetration
depth
activation
energy.
Brought
together,
all
these
milestones
have
contributed
enhancement
what
is
still
arguably
technology.
Yet
major
applications
remain
firmly
located
neoplasms,
from
where
most
new
innovations
appear
launch
areas,
such
as
microbial,
fungal,
viral,
acne,
wet
age-related
macular
degeneration,
atherosclerosis,
psoriasis,
environmental
sanitization,
pest
control,
dermatology.
Three
main
value
propositions
combinations
synergistic
additive
relatively
low
emergence
resistance
targeted
high-precision
therapy.
Combinations
established
methods
chemotherapy
radiotherapy
demonstrated
mop-up
surgery
promise
enhance
top
three
tools.
From
published
vitro
preclinical
studies,
trials
postclinical
case
seven
become
prominent
interests
because
they
are
potentially
easily
applied,
showing
enhanced
rapidly
translating
clinic.
chemotherapy,
photothermal
therapy,
magnetic
hyperthermia,
cold
plasma
sonodynamic
immunotherapy,
radiotherapy.
Photochemical
internalization
critical
mechanism
some
combinations.
Applied Sciences,
Год журнала:
2024,
Номер
14(3), С. 1132 - 1132
Опубликована: Янв. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 251 - 251
Опубликована: Фев. 8, 2024
Immunosuppressive
elements
within
the
tumor
microenvironment
are
primary
drivers
of
tumorigenesis
and
malignant
advancement.
The
presence,
as
well
crosstalk
between
myeloid-derived
suppressor
cells
(MDSCs),
osteosarcoma-associated
macrophages
(OS-Ms),
regulatory
T
(Tregs),
endothelial
(ECs)
with
osteosarcoma
cause
poor
prognosis
OS.
In
addition,
consequent
immunosuppressive
factors
favor
loss
treatment
potential.
Nanoparticles
offer
a
means
to
dynamically
locally
manipulate
immuno-nanoparticles,
which
present
promising
strategy
for
transforming
OS-TME.
Additionally,
chimeric
antigen
receptor
(CAR)
technology
is
effective
in
combating
This
review
summarizes
essential
mechanisms
OS-TME
current
immune-associated
strategies.
last
part
highlights
limitations
existing
therapies
offers
insights
into
future
research
directions.
