ACS Infectious Diseases,
Год журнала:
2024,
Номер
10(8), С. 2485 - 2506
Опубликована: Июль 13, 2024
Leishmaniasis,
a
critical
Neglected
Tropical
Disease
caused
by
Leishmania
protozoa,
represents
significant
global
health
risk,
particularly
in
resource-limited
regions.
Conventional
treatments
are
effective
but
suffer
from
serious
limitations,
such
as
toxicity,
prolonged
treatment
courses,
and
rising
drug
resistance.
Herein,
we
highlight
the
potential
of
inorganic
nanomaterials
an
innovative
approach
to
enhance
Leishmaniasis
therapy,
aligning
with
One
Health
concept
considering
these
treatments'
environmental,
veterinary,
public
impacts.
By
leveraging
adjustable
properties
nanomaterials─including
size,
shape,
surface
charge,
tailored
for
various
diseases
can
be
developed
that
less
harmful
environment
nontarget
species.
We
review
recent
advances
metal-,
oxide-,
carbon-based
combating
examining
their
mechanisms
action
dual
use
standalone
or
delivery
systems.
Our
analysis
highlights
promising
yet
underexplored
frontier
employing
materials
more
holistic
disease
management.
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(21), С. 4785 - 4798
Опубликована: Янв. 1, 2023
Magnetic
nanoparticles
(MNPs)
have
captivated
the
scientific
community
towards
biomedical
applications
owing
to
their
numerous
distinctive
physio-chemical
properties.
In
this
work,
cobalt
ferrite
(CFNPs)
and
iron
oxide
(IONPs)
were
synthesized
using
thermal
decomposition
method
then
functionalized
with
polyacrylic
acid
(PAA)
for
aqueous
dispersion.
Associated
techniques,
namely
TEM,
FESEM,
DLS,
XRD,
VSM,
used
characterize
nanoparticles.
We
also
investigated
light-induced
magnetic-field-induced
hyperthermia
properties
of
PAA-functionalized
MNPs.
It
was
found
that
PAA-CFNPs
show
a
high
specific
absorption
rate
(SAR)
compared
PAA-IONPs.
Since
blood
plasma
is
essential
delivery
targeting
drugs,
studying
biological
interactions
crucial
effective
therapeutic
use.
Therefore,
we
performed
physical
in
silico
studies
probe
into
mechanistic
interaction
CFNPs
IONPs
human
hemoglobin.
From
these
studies,
inferred
successful
binding
between
protein.
Preliminary
vitro
cytocompatibility
photothermal
toxicity
breast
cancer
(MCF-7)
cells
treated
revealed
low
dark
significant
laser-induced
toxicity.
Nano-Structures & Nano-Objects,
Год журнала:
2023,
Номер
36, С. 101053 - 101053
Опубликована: Окт. 1, 2023
According
to
WHO,
cancer
is
a
deadly
disease
and
the
second
cause
of
death
globally.
Conventional
treatment
methods,
such
as
chemotherapy,
surgery,
radiography,
etc.,
have
been
bedeviled
with
numerous
adverse
effects.
Hence,
efforts
made
find
suitable
technique
little
or
no
side
effects
for
diagnoses
treatment.
In
searching
an
alternative
medicine,
using
magnetic
nanoparticles
(MNPs)
in
diagnosis
has
recently
gained
lot
interest
among
researchers.
This
due
their
excellent
properties,
biocompatibility,
non-toxic
nature,
stability,
mention
few.
this
review,
we
extensively
discussed
various
methods
synthesis
MNPs,
comparing
merits
demerits.
The
functionalization
MNPs
reason
it
were
detailedly
described.
Also
covered
review
application
diagnosis,
including
MRI
MPI.
explained
strategies,
hyperthermia,
magnetic-guided
drug
delivery,
theranostic
platforms.
Furthermore,
use
modeling
simulation
predicting
optimizing
performance
ensure
effectiveness
was
discussed.
Finally,
looked
at
toxicity-related
concerns
future
perspective
on
applications
these
MNPs.
RSC Advances,
Год журнала:
2024,
Номер
14(22), С. 15664 - 15679
Опубликована: Янв. 1, 2024
There
is
an
incessant
demand
to
keep
improving
on
the
heating
responses
of
polymeric
magnetic
nanoparticles
(MNPs)
under
excitation,
particularly
in
pursuit
for
them
be
utilized
clinical
hyperthermia
applications.
Herein,
we
report
fabrication
a
panel
PVP-capped
divalent
metal-doped
MFe
ACS Infectious Diseases,
Год журнала:
2024,
Номер
10(8), С. 2485 - 2506
Опубликована: Июль 13, 2024
Leishmaniasis,
a
critical
Neglected
Tropical
Disease
caused
by
Leishmania
protozoa,
represents
significant
global
health
risk,
particularly
in
resource-limited
regions.
Conventional
treatments
are
effective
but
suffer
from
serious
limitations,
such
as
toxicity,
prolonged
treatment
courses,
and
rising
drug
resistance.
Herein,
we
highlight
the
potential
of
inorganic
nanomaterials
an
innovative
approach
to
enhance
Leishmaniasis
therapy,
aligning
with
One
Health
concept
considering
these
treatments'
environmental,
veterinary,
public
impacts.
By
leveraging
adjustable
properties
nanomaterials─including
size,
shape,
surface
charge,
tailored
for
various
diseases
can
be
developed
that
less
harmful
environment
nontarget
species.
We
review
recent
advances
metal-,
oxide-,
carbon-based
combating
examining
their
mechanisms
action
dual
use
standalone
or
delivery
systems.
Our
analysis
highlights
promising
yet
underexplored
frontier
employing
materials
more
holistic
disease
management.
