Recent advances in self-targeting natural product-based nanomedicines

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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Harnessing biosynthesized selenium nanoparticles for recruitment of beneficial soil microbes to plant roots

Cell Host & Microbe, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Polyamines in Plant–Pathogen Interactions: Roles in Defense Mechanisms and Pathogenicity with Applications in Fungicide Development

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 10927 - 10927

Опубликована: Окт. 11, 2024

Polyamines (PAs), which are aliphatic polycationic compounds with a low molecular weight, found in all living organisms and play essential roles plant–pathogen interactions. Putrescine, spermidine, spermine, the most common PAs nature, respond to function differently plants pathogens during their While use certain enhance immunity, exploit facilitate successful invasion. In this review, we compile recent studies on of interactions, providing comprehensive overview both plant defense pathogen pathogenicity. A thorough understanding functions conjugated highlights potential applications fungicide development. The creation new fungicides derived from demonstrates promising for further research innovation field.

Язык: Английский

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Recent advances in the application of contiguously functionalized aziridines for the synthesis of pharmaceutical precursors via regioselective ring-opening reactions

Molecular Catalysis, Год журнала: 2025, Номер 576, С. 114943 - 114943

Опубликована: Фев. 26, 2025

Язык: Английский

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Maneuvering the Bioactivities using Functionalized Biginelli Dihydropyrimidinone Amine Derivatives: Zebrafish Model System Tagged Biotoxicity is No Longer 'Fishy'

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142049 - 142049

Опубликована: Март 1, 2025

Язык: Английский

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Naringenin: A potential anticancer drug

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102358 - 102358

Опубликована: Май 1, 2025

Язык: Английский

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Unveiling the components, physiological functions and emerging trends of hydroxycinnamic acid amides in goji berry (Lycium)

Food Research International, Год журнала: 2025, Номер unknown, С. 116696 - 116696

Опубликована: Май 1, 2025

Язык: Английский

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Evaluation of anticancer and antimicrobial activities of novel dihydropyrimidinone derivatives

Опубликована: Фев. 21, 2024

Dihydropyrimidinone (DHPM) can be synthesized through a simple one-pot Biginelli reaction. Off-late medicinal properties of DHPM have been discovered. In our recent work, we shown that the florescent property appended to this molecule while retaining its therapeutic attributes. derivatives substituted with different alkylating groups like ethyl-, mono-, di-, and tri- ethanol amines. This current paper discusses multifunctionality in form anticancer antimicrobial agent. exhibit improved inhibitory effects vitro assay. The are tested for their anti-cancer on A549 cell lines, as well anti-bacterial anti-fungal clinically significant pathogens Staphylococcus aureus, Methicillin Resistant aureus (MRSA), Escherichia coli, Colistin Pseudomonas aeruginosa, Candida albicans. These discoveries reveal good opportunity develop multifunctional medicine based DHPM. synthesis presence radical moieties supported by chemical studies.

Язык: Английский

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Nickel-Catalyzed, Aminoquinoline-Directed Chemo- and Regioselective Carboamination of Unactivated Olefins with Organoboronic Acids and Anthranils

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

A nickel-catalyzed three-component carboamination of unactivated alkenes with organoboronic acids and anthranils has been achieved for the expedient synthesis δ-aryl γ-amino acid derivatives. The 8-aminoquinoline (AQ) directing group is crucial success reaction, anthranil serves as an arylnitrene precursor in this conversion. This method features mild reaction conditions, good chemo- regioselectivity, a broad substrate scope functional tolerance.

Язык: Английский

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Revealing Commercial Epoxy Resins’ Antimicrobial Activity: A Combined Chemical–Physical, Mechanical, and Biological Study

Polymers, Год журнала: 2024, Номер 16(18), С. 2571 - 2571

Опубликована: Сен. 11, 2024

In our continuing search for new polymer composites with antimicrobial activity, we observed that even unmodified epoxy resins exhibit significant activity. Considering their widespread use as starting materials the realization of multifunctional nanocomposites excellent chemical and mechanical properties, it was deemed relevant to uncover these unexpected properties can lead novel applications. fact, in places where contact human activities makes working surfaces susceptible microbial contamination, thus jeopardizing sterility environment, biological activity opens way successful application minimizing healthcare-associated infections. To this end, three commercial widely used (DGEBA/Elan-TechW 152LR, 1; EPIKOTETM Resin MGS®/EPIKURETM RIM H 235, 2 MC152/EW101, 3) have been investigated determine antibacterial antiviral After 24 h, according ISO 22196:2011, 1 showed a high efficacy (R value > 6.0 log reduction) against Staphylococcus aureus Escherichia coli. 2, prepared ratio epoxy/hardener indicated by supplier (sample 2a) 10% w/w hardener excess 2b), exhibited an intriguing virucidal Herpes Simplex Virus type-1 Human Coronavirus type V-OC43 surrogate SARS-CoV-2.

Язык: Английский

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