Induction
of
systemic
acquired
resistance
(SAR)
in
plants
to
control
bacterial
diseases
has
become
an
effective
solution
the
problems
agrochemical
and
ecological
environment
damage
caused
by
long-term
large-scale
use
traditional
bactericides.
However,
current
SAR-inducing
compounds
are
often
unable
rapidly
eliminate
pathogenic
bacteria
infected
plant
tissues
prevent
further
spread
disease,
severely
restraining
potential
for
extensive
application
agriculture.
Herein,
we
address
limitations
developing
a
series
visible-light-absorbing
aggregation-induced
emission
photosensitizers
suitable
agricultural
use.
The
photosensitizer
(MTSQ2)
is
modulated
molecular
engineering
have
optimal
optical
properties,
reactive
oxygen
species
(ROS)
generation
efficiency,
targeting
affinity,
thereby
exhibiting
antibacterial
photodynamic
activity
against
phytopathogenic
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5222 - 5222
Опубликована: Май 10, 2024
Flavonoids,
a
variety
of
plant
secondary
metabolites,
are
known
for
their
diverse
biological
activities.
Isoflavones
subgroup
flavonoids
that
have
gained
attention
potential
health
benefits.
Puerarin
is
one
the
bioactive
isoflavones
found
in
Kudzu
root
and
Pueraria
genus,
which
widely
used
alternative
Chinese
medicine,
has
been
to
be
effective
treating
chronic
conditions
like
cardiovascular
diseases,
liver
gastric
respiratory
diabetes,
Alzheimer’s
disease,
cancer.
extensively
researched
both
scientific
clinical
studies
over
past
few
years.
The
purpose
this
review
provide
an
up-to-date
exploration
puerarin
biosynthesis,
most
common
extraction
methods,
analytical
techniques,
effects,
new
perspective
medical
pharmaceutical
research
development.
Natural Product Reports,
Год журнала:
2024,
Номер
41(6), С. 905 - 934
Опубликована: Янв. 1, 2024
This
review
presents
a
comprehensive
overview
of
recent
advances
in
the
discovery
methodologies,
new
structures,
bioactivities,
and
unique
biosynthetic
logics
myxobacterial
natural
products
reported
from
January
2017
to
November
2023.
Processes,
Год журнала:
2025,
Номер
13(2), С. 350 - 350
Опубликована: Янв. 27, 2025
Puerarin
(daidzein-8-C-glucoside),
one
of
the
bioactive
isoflavones,
has
attracted
attention
in
various
industries
due
to
its
excellent
pharmacological
effects
such
as
antioxidant
effect,
estrogen-like
activity,
reduction
blood
sugar,
and
neuroprotective
effect.
is
most
abundantly
found
roots
Pueraria
lobata
(RPL)
among
biomass
sources.
To
improve
utilization
feasibility
puerarin,
a
high-yield
extraction
process
should
be
designed
for
RPL.
This
study
aimed
optimize
more
efficiently
recover
puerarin
from
RPL
while
using
generally
recognized
safe
solvents
solvents,
considering
potential
industrial
applications
puerarin.
The
variables
were
optimized
by
one-factor-at-a-time
method,
response
surface
methodology,
time
profiling
study.
As
result,
yield
was
achieved
at
60.56
mg/g
under
optimal
conditions
(ethanol
concentration
46.06%,
temperature
65.02
°C,
ratio
solvent
11.50
mL/g,
22
min).
High
this
contributed
improving
applicability
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 9, 2025
Maintaining
wound
breathability
and
preventing
infection
are
crucial
for
moist
healing.
However,
existing
hydrogel
dressings
suffer
from
poor
clinically
used
antimicrobial
agents
such
as
antibiotics,
metal
nanoparticles,
natural
substances
face
challenges
including
resistance,
toxicity,
high
extraction
costs,
respectively.
Inspired
by
the
properties
of
airway
surface
liquid
(ASL),
a
biomimetic
moisturizing
antibacterial
dressing
(BMAHD)
is
designed.
It
combines
polyvinyl
alcohol
(PVA)
with
ordinary
gauze
to
achieve
breathability,
while
also
secreting
water-glycerol
mixture
moisturize
wound.
Interestingly,
Na2CO3
secreted
achieves
broad-spectrum
bactericidal
effects,
up
99%
sterilization
rates
within
24
h.
Furthermore,
co-cultivation
experiments
mouse
embryonic
fibroblasts
(L929)
sheep
red
blood
cells
(SRBC)
demonstrate
excellent
cellular
compatibility
dressing.
To
prove
concept,
animal
model
confirms
that
BMAHD
significantly
promotes
The
provides
valuable
reference
design
novel
medical
dressings.
Journal of Natural Products,
Год журнала:
2024,
Номер
87(2), С. 217 - 227
Опубликована: Янв. 19, 2024
The
urgent
need
for
new
classes
of
orally
available,
safe,
and
effective
antivirals─covering
a
breadth
emerging
viruses─is
evidenced
by
the
loss
life
economic
challenges
created
HIV-1
SARS-CoV-2
pandemics.
As
frontline
interventions,
small-molecule
antivirals
can
be
deployed
prophylactically
or
postinfection
to
control
initial
spread
outbreaks
reducing
transmissibility
symptom
severity.
Natural
products
have
an
impressive
track
record
success
as
prototypic
continue
provide
drugs
through
synthesis,
medicinal
chemistry,
optimization
decades
after
discovery.
Here,
we
demonstrate
approach
using
computational
analysis
typically
used
rational
drug
design
identify
develop
natural
product-inspired
antivirals.
This
was
done
with
goal
identifying
product
prototypes
aid
effort
progressing
toward
effective,
affordable
broad-spectrum
inhibitors
Betacoronavirus
replication
targeting
highly
conserved
RNA
2′-O-methyltransferase
(2′-O-MTase).
Machaeriols
RS-1
(7)
RS-2
(8)
were
identified
previously
outlined
informatics
first
screen
prototypes,
followed
in
silico-guided
synthesis.
Both
molecules
are
based
on
rare
group.
machaeriols
(3–6),
isolated
from
genus
Machaerium,
endemic
Amazonia,
inhibited
2′-O-MTase
more
potently
than
positive
control,
Sinefungin
(2),
silico
modeling
suggests
distinct
molecular
interactions.
report
highlights
potential
computationally
driven
screening
leverage
libraries
improve
efficiency
isolation
synthetic
analog
development.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(31), С. 17229 - 17239
Опубликована: Июль 25, 2024
In
this
study,
a
series
of
novel
hydrazide-containing
flavonol
derivatives
was
designed,
synthesized,
and
evaluated
for
antifungal
activity.
the
in
vitro
assay,
most
target
compounds
exhibited
potent
activity
against
seven
tested
phytopathogenic
fungi.
particular,
compound
C32
showed
best
Rhizoctonia
solani
(EC50
=
0.170
μg/mL),
outperforming
carbendazim
0.360
μg/mL)
boscalid
1.36
μg/mL).
Compound
C24
excellent
Valsa
mali,
Botrytis
cinerea,
Alternaria
alternata
with
EC50
values
0.590,
0.870,
1.71
μg/mL,
respectively.
The
vivo
experiments
revealed
that
were
potential
agricultural
antifungals.
3D
quantitative
structure–activity
relationship
(3D-QSAR)
models
used
to
analyze
relationships
these
compounds.
analysis
results
indicated
introducing
appropriate
electronegative
groups
at
position
4
benzene
ring
could
effectively
improve
anti-R.
mechanism
scanning
electron
microscopy
transmission
analyses
disrupted
normal
growth
hyphae
by
affecting
structural
integrity
cell
membrane
cellular
respiration.
Furthermore,
succinate
dehydrogenase
(SDH)
inhibitory
(IC50
8.42
μM),
surpassing
SDH
fungicide
15.6
μM).
molecular
dynamics
simulations
docking
suggested
can
occupy
active
site
form
strong
interactions
key
residues
SDH.
Our
findings
have
great
aiding
future
research
on
plant
disease
control
agriculture.
