Abstract
Diabetes
significantly
impairs
the
body's
wound‐healing
capabilities,
leading
to
chronic,
infection‐prone
wounds.
These
wounds
are
characterized
by
hyperglycemia,
inflammation,
hypoxia,
variable
pH
levels,
increased
matrix
metalloproteinase
activity,
oxidative
stress,
and
bacterial
colonization.
complex
conditions
complicate
effective
wound
management,
prompting
development
of
advanced
diabetic
care
strategies
that
exploit
specific
characteristics
such
as
acidic
pH,
high
glucose
stress
trigger
controlled
drug
release,
thereby
enhancing
therapeutic
effects
dressings.
Among
solutions,
hydrogels
emerge
promising
due
their
stimuli‐responsive
nature,
making
them
highly
for
managing
these
The
latest
advancements
in
mono/multi‐stimuli‐responsive
smart
showcase
superiority
potential
healthcare
materials,
highlighted
relevant
case
studies.
However,
traditional
dressings
fall
short
meeting
nuanced
needs
wounds,
adjustable
adhesion,
easy
removal,
real‐time
status
monitoring,
dynamic
release
adjustment
according
wound's
conditions.
Responsive
represent
a
significant
leap
forward
proficient
sensing
responding
environment,
offering
more
targeted
approach
treatment.
This
review
highlights
recent
dressing,
delivery,
emphasizing
role
improving
healing.
It
addresses
ongoing
challenges
future
directions,
aiming
guide
clinical
adoption.
Abstract
Bacterial
biofilm‐related
infectious
diseases
severely
influence
human
health.
Under
typical
situations,
pathogens
can
colonize
inert
or
biological
surfaces
and
form
biofilms.
Biofilms
are
functional
aggregates
that
coat
bacteria
with
extracellular
polymeric
substances
(EPS).
The
main
reason
for
the
failure
of
biofilm
infection
treatment
is
low
permeability
enrichment
therapeutic
agents
within
biofilm,
which
results
from
particular
features
matrix
barriers
such
as
negatively
charged
components
highly
viscous
compact
EPS
structures.
Hence,
developing
novel
strategies
enhanced
penetrability
crucial.
Herein,
current
progress
nanotechnology
methods
to
improve
agents’
against
matrix,
regulating
material
morphology
surface
properties,
utilizing
physical
penetration
nano/micromotors
microneedle
patches,
equipping
nanoparticles
degradation
enzymes
signal
molecules,
first
summarized.
Finally,
challenges,
perspectives,
future
implementations
engineered
delivery
systems
manage
infections
presented
in
detail.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 24, 2023
Abstract
The
stimuli-responsive
nanofibers
prepared
by
electrospinning
have
become
an
ideal
material
due
to
their
large
specific
surface
area
and
porosity,
which
can
respond
extremely
quickly
external
environmental
incitement.
As
intelligent
drug
delivery
platform,
efficiently
load
drugs
then
be
stimulated
conditions
(light,
temperature,
magnetic
field,
ultrasound,
pH
or
ROS,
etc.)
achieve
slow,
on-demand
targeted
release,
showing
great
potential
in
areas
such
as
delivery,
tumor
therapy,
wound
dressing,
tissue
engineering.
Therefore,
this
paper
reviews
the
recent
trends
of
electrospun
platforms
field
biomedicine.
Abstract
The
emergence
of
drug‐resistant
bacteria
poses
a
significant
threat
to
people's
lives
and
health
as
bacterial
infections
continue
persist.
Currently,
antibiotic
therapy
remains
the
primary
approach
for
tackling
infections.
However,
escalating
rates
drug
resistance
coupled
with
lag
in
development
novel
drugs
have
led
diminishing
effectiveness
conventional
treatments.
Therefore,
nonantibiotic‐dependent
therapeutic
strategies
has
become
imperative
impede
rise
resistance.
chemodynamic
(CDT)
opened
up
new
possibility
due
CDT
can
convert
H
2
O
into
•OH
via
Fenton/Fenton‐like
reaction
treatment.
efficacy
is
limited
by
variety
practical
factors.
To
overcome
this
limitation,
sterilization
efficiency
be
enhanced
introducing
therapeutics
inherent
antimicrobial
capability.
In
addition,
researchers
explored
CDT‐based
combined
therapies
augment
its
effects
mitigate
potential
toxic
side
toward
normal
tissues.
This
review
examines
research
progress
field,
explores
various
enhance
presents
synergistic
combination
other
modalities.
And
last,
current
challenges
faced
future
directions
are
discussed.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(14), С. 17612 - 17626
Опубликована: Апрель 3, 2023
Along
with
hypoxia,
severe
bacterial
infection,
and
abnormal
pH,
continuous
inflammatory
response
hinders
diabetic
wounds
from
healing.
It
leads
to
the
accumulation
of
large
amounts
reactive
oxygen
species
(ROS)
therefore
prevents
transition
phase
proliferative
phase.
In
this
work,
a
nanohybrid
double
network
hydrogel
injectable,
self-healing,
tissue
adhesion
properties
based
on
platinum
nanozyme
composite
(PFOB@PLGA@Pt)
was
constructed
manage
wound
PFOB@PLGA@Pt
exhibited
supply
capacity
enzyme
catalytic
performance
accompanied
by
pH
self-regulation
in
entire
phases
first
stage,
carried
perfluorooctyl
bromide
(PFOB)
can
ameliorate
hypoxia
boost
glucose
oxidase-like
catalyzed
reaction
Pt
NPs,
leading
lowered
environment
gluconic
acid.
As
result,
NADH
oxidase-like,
peroxidase-like,
multiple
activities
were
activated
successively,
synergistic
antibacterial
effects
through
production
ROS.
After
infection
had
cleared,
catalase-like
superoxide
dismutase-like
NPs
reshaped
redox
microenvironment
scavenging
excess
ROS,
which
transitioned
The
microenvironmentally
adaptive
treatment
cover
all
healing,
showing
significant
promoting
effect
repair
infected
wounds.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
279, С. 134578 - 134578
Опубликована: Авг. 8, 2024
Because
of
the
complex
symptoms
resulting
from
metabolic
dysfunction
in
wound
microenvironment
during
bacterial
infections,
along
with
necessity
to
combat
free
radicals,
achieving
prompt
and
thorough
healing
remains
a
significant
medical
challenge
that
has
yet
be
fully
addressed.
Moreover,
misuse
common
antibiotics
contributed
emergence
drug-resistant
bacteria,
underscoring
need
for
enhancements
practical
commonly
utilized
approach
treatment.
In
this
context,
hydrogel
dressings
based
on
biological
macromolecules
antibacterial
antioxidant
properties
present
promising
new
avenue
skin
treatment
due
their
multifunctional
characteristics.
Despite
considerable
potential
innovative
care,
comprehensive
research
these
is
still
insufficient.
Consequently,
development
advanced
macromolecule-based
hydrogels,
such
as
chitosan,
alginate,
cellulose,
hyaluronic
acid,
others,
been
primary
focus
study.
These
materials
have
enriched
various
agents
confer
attributes
purposes.
This
review
article
aims
offer
overview
latest
progress
field,
providing
critical
theoretical
basis
future
advancements
utilization
hydrogels
healing.
