Biomedical materials for wound dressing: recent advances and applications

RSC Advances, Journal Year: 2023, Volume and Issue: 13(8), P. 5509 - 5528

Published: Jan. 1, 2023

Wound healing is vital to maintain the physiological functions of skin.

Language: Английский

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Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Small, Journal Year: 2022, Volume and Issue: 19(6)

Published: Dec. 5, 2022

Abstract Bacterial biofilm‐related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is low permeability enrichment therapeutic agents within biofilm, which results from particular features matrix barriers such as negatively charged components highly viscous compact EPS structures. Hence, developing novel strategies enhanced penetrability crucial. Herein, current progress nanotechnology methods to improve agents’ against matrix, regulating material morphology surface properties, utilizing physical penetration nano/micromotors microneedle patches, equipping nanoparticles degradation enzymes signal molecules, first summarized. Finally, challenges, perspectives, future implementations engineered delivery systems manage infections presented in detail.

Language: Английский

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Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 24, 2023

Abstract The stimuli-responsive nanofibers prepared by electrospinning have become an ideal material due to their large specific surface area and porosity, which can respond extremely quickly external environmental incitement. As intelligent drug delivery platform, efficiently load drugs then be stimulated conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) achieve slow, on-demand targeted release, showing great potential in areas such as delivery, tumor therapy, wound dressing, tissue engineering. Therefore, this paper reviews the recent trends of electrospun platforms field biomedicine.

Language: Английский

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Oct. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Language: Английский

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Nanohybrid Double Network Hydrogels Based on a Platinum Nanozyme Composite for Antimicrobial and Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(14), P. 17612 - 17626

Published: April 3, 2023

Along with hypoxia, severe bacterial infection, and abnormal pH, continuous inflammatory response hinders diabetic wounds from healing. It leads to the accumulation of large amounts reactive oxygen species (ROS) therefore prevents transition phase proliferative phase. In this work, a nanohybrid double network hydrogel injectable, self-healing, tissue adhesion properties based on platinum nanozyme composite (PFOB@PLGA@Pt) was constructed manage wound PFOB@PLGA@Pt exhibited supply capacity enzyme catalytic performance accompanied by pH self-regulation in entire phases first stage, carried perfluorooctyl bromide (PFOB) can ameliorate hypoxia boost glucose oxidase-like catalyzed reaction Pt NPs, leading lowered environment gluconic acid. As result, NADH oxidase-like, peroxidase-like, multiple activities were activated successively, synergistic antibacterial effects through production ROS. After infection had cleared, catalase-like superoxide dismutase-like NPs reshaped redox microenvironment scavenging excess ROS, which transitioned The microenvironmentally adaptive treatment cover all healing, showing significant promoting effect repair infected wounds.

Language: Английский

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Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 1 - 19

Published: Feb. 7, 2024

Language: Английский

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Emerging trends in the application of hydrogel-based biomaterials for enhanced wound healing: A literature review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129300 - 129300

Published: Jan. 11, 2024

Language: Английский

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Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing

Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151

Published: Oct. 15, 2024

Language: Английский

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Recent advances of hydrogels as smart dressings for diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(5), P. 1126 - 1148

Published: Jan. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Language: Английский

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Biological macromolecule-based hydrogels with antibacterial and antioxidant activities for wound dressing: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 134578 - 134578

Published: Aug. 8, 2024

Because of the complex symptoms resulting from metabolic dysfunction in wound microenvironment during bacterial infections, along with necessity to combat free radicals, achieving prompt and thorough healing remains a significant medical challenge that has yet be fully addressed. Moreover, misuse common antibiotics contributed emergence drug-resistant bacteria, underscoring need for enhancements practical commonly utilized approach treatment. In this context, hydrogel dressings based on biological macromolecules antibacterial antioxidant properties present promising new avenue skin treatment due their multifunctional characteristics. Despite considerable potential innovative care, comprehensive research these is still insufficient. Consequently, development advanced macromolecule-based hydrogels, such as chitosan, alginate, cellulose, hyaluronic acid, others, been primary focus study. These materials have enriched various agents confer attributes purposes. This review article aims offer overview latest progress field, providing critical theoretical basis future advancements utilization hydrogels healing.

Language: Английский

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