A rhodium-catalyzed cascade C–H activation/annulation strategy for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(17), С. 3523 - 3532

Опубликована: Янв. 1, 2024

We have developed a cascade annulation strategy triggered by rhodium( iii )-catalyzed C–H activation for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines from free NH-sulfoximines with maleimides under mild conditions.

Язык: Английский

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Ruthenium(II)-Catalyzed Annulation of Oximes with Maleimides: Synthesis of Pyrrolo[3,4-c]isoquinoline-1,3-diones

Organic Letters, Год журнала: 2024, Номер 26(33), С. 6977 - 6982

Опубликована: Авг. 5, 2024

A series of pyrroloisoquinoline-1,3-diones has been synthesized using ruthenium(II) as the catalyst and oxygen oxidant in a straightforward manner. The reaction proceeds through tandem C-C/C-N bond formation process between maleimides ketoximes, providing direct approach for synthesis titled products. This operationally simple procedure supplies suitable conditions synthesizing diverse isoquinoline-based heterocycles with range functional groups moderate to good yields compatible gram-scale synthesis. Furthermore, compatibility this green environmentally friendly raises importance present method.

Язык: Английский

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Rhodium(III)-Catalyzed Regioselective C4 Alkylation of Indoles with Nitroalkenes

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

The Rh(III)-catalyzed indole C4-H bond addition to nitroalkenes is disclosed under mild and redox-neutral reaction conditions, offering straightforward access various 4-(2-nitroalkyl)indoles (34 examples) with excellent chemo- regioselectivity. Furthermore, late-stage diversifications mechanistic studies were also performed.

Язык: Английский

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Ruthenium(ii)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones – insights into additive-controlled product selectivity

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(13), С. 2695 - 2699

Опубликована: Янв. 1, 2023

Herein, we developed ruthenium(II)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones. The product selectivity is controlled by the additives, hydroarylated was obtained in water, which an important highlight this study. Control experiments were conducted to elucidate a plausible mechanism. These suggest occurrence pathway over E2-type elimination - key step producing Heck-type products.

Язык: Английский

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Ir(III)-Catalyzed Novel Three-Component Cascade Trifluoroethoxylation and One-Pot Method to Construct Complex Amide Compounds

Chinese Journal of Organic Chemistry, Год журнала: 2023, Номер 43(3), С. 1115 - 1115

Опубликована: Янв. 1, 2023

Ir(III)-catalyzed three-component cascade reaction to construct unique trifluoroethoxylation amide compounds has been developed, meanwhile the fluorinated could continue react with alcohols prepare complex spiro isoindolinone derivatives in one-pot.The highly efficient approaches produce various by conditioncontrolled.

Язык: Английский

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