Molecules,
Год журнала:
2023,
Номер
28(2), С. 618 - 618
Опубликована: Янв. 7, 2023
Spirooxindoles
occupy
an
important
place
in
heterocyclic
chemistry.
Many
natural
spirooxindole-containing
compounds
have
been
identified
as
bio-promising
agents.
Synthetic
analogs
also
synthesized
utilizing
different
pathways.
The
present
article
summarizes
the
recent
development
of
both
and
synthetic
prepared
from
isatin
or
its
derivatives
reported
last
five
years.
spirooxindoles
are
categorized
based
on
their
mentioned
biological
properties.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(16), С. 11562 - 11580
Опубликована: Июль 27, 2023
Diverse
functionalized
dihydrobenzofuran
spiro-indanedione-oxindole
scaffolds
were
conveniently
synthesized
by
base-promoted
cyclization
reaction
of
Morita-Baylis-Hillman
(MBH)
carbonates
isatins
and
2-(o-hydroxybenzylidene)-1,3-indanediones.
The
two
diastereomeric
dispiro[indene-2,1'-cyclopenta[b]benzofuran-2',3″'-indolines]
could
be
selectively
using
DABCO
or
DMAP
as
a
base
promoter.
More
importantly,
facilitated
the
annulation
MBH
formates
2-(o-hydroxybenzylidene)-1,3-indanediones
selectively,
resulting
in
spiro[cyclopropa[c]chromene-1,2'-indene]-1',3'-diones
dispiro[indene-2,1'-cyclopenta[b]benzofuran-2',3″'-indolines].
Additionally,
similar
with
maleimides
afforded
dispiro[indene-2,5'-benzofuro[2',3':1,5]cyclopenta[1,2-c]pyrrole-4',3″'-indolines]
high
yields
diastereoselectivity.
PLoS ONE,
Год журнала:
2025,
Номер
20(4), С. e0319791 - e0319791
Опубликована: Апрель 1, 2025
The
eco-friendly
method
of
producing
copperـoxide
nanoparticles
through
the
use
okra
fruit
extract
is
a
simple,
economical,
rapid,
and
sustainable
technique.
resultant
(CuO
NP)
were
analyzed
with
several
analytical
methods,
such
as
UV-vis
spectroscopy,
FourierـTransform
Infrared
Spectroscopy
(FT-IR),
X-Ray
Diffraction
(XRD),
Zeta
potential,
TransmissionـElectron
Microscopy
(TEM)
EnergyـDispersive
X-ray
(EDX)
analysis.
CuO
NP
exhibited
maximum
absorbance
at
381
nm.
formation
was
further
confirmed
by
characteristic
bands
observed
534
588
cm
-1
.
monoclinic
structure
identified
prominent
peaks
detected
2θ
values
32.47°,
35.43°,
38.64°,
48.68°,
53.38°,
58.14°,
61.39°,
66.11°,
67.82°,
72.27°,
74.96°.
overall
findings
indicate
that
had
an
average
diameter
in
approximate
range
10
to
30
nm
based
on
TEM
cytotoxicity
study,
conducted
Human
Fibroblast
normal
HFB4
cell
lines,
indicated
halfـmaximal
inhibitory
concentration
(IC50)
dose
236.34
μg/mL.
An
IC50
109.46
μg/mL
found
antitumor
effect
studies
using
breast
adenocarcinoma
Mcf-
7
revealing
good
level
safety
for
NP.
According
antibacterial
Staphylococcus
aureus
Bacillus
cereus
inhibition
zone
diameters
(IZDs)
29.5
±
0.7
mm
24.6
1.2
mm,
respectively,
making
them
most
vulnerable
bacteria
In
contrast,
P.
aeruginosa
least
sensitive
strain,
minimum
IZD
15
1.6
mm.
Compared
gram-negative
infections,
NPs
have
significantly
higher
effectiveness
versus
Gram
-positive
pathogens.
Molecular
docking
against
dihydrofolate
reductase
(DHFR)
(PDB
ID:
6P9Z)
illustrated
partially
interlocked
active
site
6P9Z
fitting
energy
value
-44.93
kcal/mol
five
classical
hydrogen
bonds
Ala7,
Gln9,
Thr46,
Ser49,
Phe92.
last
one
also
generated
marketing
antifolate
agent
methotrexate
(MTX),
adding
some
MTX-like
character
inhibitor.
Organic Letters,
Год журнала:
2022,
Номер
24(42), С. 7790 - 7795
Опубликована: Окт. 14, 2022
We
have
developed
an
efficient
protocol
for
the
construction
of
polycyclic
dihydrobenzofuran
spirooxindole
scaffolds
via
base
promoted
cascade
annulation
Morita-Baylis-Hillman
(MBH)
carbonates
isatins
with
ortho-hydroxychalcones
or
ortho-hydroxy-β-nitrostyrenes.
The
complex
compounds
were
conveniently
synthesized
in
satisfactory
yields
and
high
diastereoselectivity.
This
provides
a
swift
convenient
approach
assembly
diverse
highly
functionalized
spirooxindoles
also
features
broad
substrate
scope,
molecular
convergence,
excellent
atomic
economy.
RSC Advances,
Год журнала:
2023,
Номер
13(11), С. 7063 - 7075
Опубликована: Янв. 1, 2023
Recent
updates
on
the
synthesis
of
CF
3
-containing
spirocyclic-oxindoles
by
employing
N
-2,2,2-trifluoroethylisatin
ketimines
are
described
in
this
review
article.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(7), С. 1518 - 1530
Опубликована: Янв. 1, 2023
A
highly
efficient
pot,
atom,
and
step
economical
method
for
the
construction
of
pharmacologically
potent
structurally
functionalized
1,4-dihydropyridines,
quaternary
centered
C-3
spiro[indoline-3,4'-pyridines],
C-11
spiro[indeno[1,2-b]quinoxaline-11,4'-pyridines]
via
rose
bengal
photoredox
catalysis
under
blue
LED
irradiation
in
an
aqueous
medium
at
room
temperature
has
been
developed.
The
products
were
isolated
excellent
yields
within
a
short
reaction
time
variety
functional
groups
transition
metal-
ligand-free
energy-efficient
conditions
green
solvent
system
with
high
mass
efficiency
process
intensity,
which
are
key
advantages
current
work.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(3)
Опубликована: Фев. 3, 2023
Abstract
Spirocyclic
compounds,
particularly
spirooxindoles
that
comprise
a
tetrahedral
sp
3
‐hybridized
carbon
atom
at
the
C‐3
position
of
an
orthogonally
shaped
bicyclic
structure
have
recently
received
increasing
attention
in
drug
discovery
and
development,
besides
their
major
potential
natural
products
synthetic
organic
chemistry.
They
are
found
to
be
structural
constituents
many
alkaloids,
key
active
building
blocks
for
construction
various
pharmaceutically
significant
molecules.
On
other
hand,
with
awareness
people
about
protecting
health
living
environment
from
pollution
caused
by
chemical
laboratories
industry,
development
method
provides
alternatives
traditional
one
introducing
economical
sustainable
processes
is
scientifically
technically
demanding
but
challenging.
To
address
these
concerns
inspired
photosynthesis
process,
visible
light‐induced
chemistry
appears
highly
economic,
sustainable,
alternative
approach
synthesis.
The
present
mini‐review
aims
highlight
recent
progress
accomplished
straightforward
accelerated
light
irradiation
period
2015
date.
Besides
reviewing
advantages
achieved
this
field,
we
also
attempt
find
out
drawback,
mechanistic
rationalization,
scopes
future
applications.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(21)
Опубликована: Март 16, 2023
Oxindoles
and
iso-oxindoles
are
natural
product-derived
scaffolds
that
provide
inspiration
for
the
design
synthesis
of
novel
biologically
relevant
compound
classes.
Notably,
spirocyclic
connection
oxindoles
with
has
not
been
explored
by
nature
but
promises
to
structurally
related
compounds
endowed
bioactivity.
Therefore,
methods
their
efficient
conclusive
discovery
cellular
targets
highly
desirable.
We
describe
a
selective
RhIII
-catalyzed
scaffold-divergent
spirooxindole-isooxindoles
spirooxindole-oxindoles
from
differently
protected
diazooxindoles
N-pivaloyloxy
aryl
amides
which
includes
functional
group-controlled
Lossen
rearrangement
as
key
step.
Unbiased
morphological
profiling
corresponding
collection
in
Cell
Painting
assay
efficiently
identified
mitotic
kinesin
Eg5
target
spirooxindoles,
defining
unique
inhibitor
chemotype.
