Developments in Synthesis Strategies of Spiro-Barbiturate Compounds: A Classified Study

Mini-Reviews in Organic Chemistry, Год журнала: 2023, Номер 21(2), С. 246 - 270

Опубликована: Май 1, 2023

Abstract: Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three dimensionalities, and prominently hold position of interest in the fields synthetic medicinal chemistry, pharmacology, material sciences physics. Spirobarbiturate which incorporate barbituric ring derivatives into spirocyclic structures emerged as attractive targets for drug discovery they are known to exhibit far-ranging pharmacological applications. In this review, we aim bring light extensive, contemporary research applied synthesis different spirobarbiturates having varied sizes (3, 5, 6 7 membered) classified manner. It presents reported methods along with their mechanistic pathways well activities some these synthesized biologically significant motifs.

Язык: Английский

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Synthesis of Benzofuran Derivatives via a DMAP-Mediated Tandem Cyclization Reaction Involving ortho-Hydroxy α-Aminosulfones

Molecules, Год журнала: 2024, Номер 29(16), С. 3725 - 3725

Опубликована: Авг. 6, 2024

An efficient cascade cyclization strategy was developed to synthesize aminobenzofuran spiroindanone and spirobarbituric acid derivatives utilizing 2-bromo-1,3-indandione, 5-bromo-1,3-dimethylbarbituric acid,

Язык: Английский

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Pd/Mengphos-Catalyzed High-order [4+4] Cycloaddition for Efficient Synthesis of Oxazocines

Synthesis, Год журнала: 2024, Номер 56(24), С. 3870 - 3878

Опубликована: Окт. 7, 2024

Abstract The development of new catalytic systems that enable regio- and chemoselective construction diversely functionalized oxazocines is an important topic in organic synthesis pharmacochemistry. Herein, a novel Pd/Mengphos complex was designed applied palladium-catalyzed high-order [4+4] cycloaddition 2-substituted allylic carbonates to α,β-unsaturated imines, allowing facile access versatile good yields with excellent b/l Z/E selectivities (up 92% yield complete selectivities). reaction exhibited broad substrate scope, mild conditions, functional group compatibility. In addition, asymmetric version has also been tested, affording the desired moderate enantioselectivity.

Язык: Английский

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Recent Advances in Palladium-Catalyzed Annulations for the Synthesis of Pyrrolidines

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141010 - 141010

Опубликована: Дек. 1, 2024

Язык: Английский

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