Photo-induced synthesis of fluoroalkylated quinolinones via an iron-catalyzed LMCT decarboxylation process

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(16), С. 4436 - 4441

Опубликована: Янв. 1, 2024

A general synthesis of fluoroalkylated quinolone compounds using a visible-light-induced iron catalyzed LMCT method is reported herein.

Язык: Английский

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Metal-free synthesis of carbamoylated dihydroquinolinones via cascade radical annulation of cinnamamides with oxamic acids

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(9), С. 1821 - 1833

Опубликована: Янв. 1, 2024

Metal-free synthesis of medicinally important carbamoylated dihydroquinolinones using readily available, cheap and environment-friendly materials with good to excellent yields.

Язык: Английский

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Visible-Light-Induced Cascade Cyclization of 1-Acryloyl-2-cyanoindole: Access of Difluoroalkylated Pyrrolo[1,2-a]indolediones

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(23), С. 16598 - 16608

Опубликована: Ноя. 10, 2023

An effective method for accessing diverse difluoroalkylated pyrrolo[1,2-a]indolediones via visible-light-induced PhI(OAc)2-promoted cascade difluoroalkylation/cyclization reaction under mild conditions has been established. This is noteworthy its use of DMSO-H2O as a green medium at room temperature and avoidance photocatalysts. The reactions are straightforward to execute convenient expand on, provide good excellent yields, have functional group tolerance.

Язык: Английский

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Photo-induced decarboxylative radical cascade cyclization of unactivated alkenes: access to CF- and CF₂-substituted ring-fused imidazoles

RSC Advances, Год журнала: 2025, Номер 15(16), С. 12739 - 12745

Опубликована: Янв. 1, 2025

A mild and effective visible-light-induced decarboxylative radical cascade reaction of olefin-containing imidazoles α-fluorinated carboxylic acids, has been developed to afford monofluoromethylated or aryldifluoromethylated polycyclic imidazoles.

Язык: Английский

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Cyclizations of Alkenyl(Alkynyl)‐Functionalized Quinazolinones and their Heteroanalogues: A Powerful Strategy for the Construction of Polyheterocyclic Structures

The Chemical Record, Год журнала: 2023, Номер 24(2)

Опубликована: Окт. 13, 2023

Quinazolin-4-one, its heteroanalogues, and derivatives represent an outstandingly important class of compounds in modern organic, medicinal, pharmaceutical chemistry, as these molecular structures are noted for their wide synthetic pharmacological potential. In the last years, ever-increasing research attention has been paid to quinazolinone bearing alkenyl alkynyl substituents on pyrimidinone nucleus. The original structural combination synthetically powerful endocyclic amidine (or amidine-related) exocyclic unsaturated moieties provides a driving force cyclizations, which offer efficient toolkit construct variety fused pyrimidine systems with saturated N- N,S-heterocycles. this connection, present review article is mainly aimed at systematic coverage progress using alkenyl(alkynyl)quinazolinones heteroanalogues convenient bifunctional substrates regioselective annulation small- medium-sized heterocyclic nuclei. Much elucidating electronic effects reagents regio- stereoselectivity cyclizations well clarifying relevant reaction mechanisms.

Язык: Английский

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Visible-Light-Induced Intramolecular Tandem Cyclization of Unactivated Indoloalkynes for the Synthesis of Sulfonylated and Selenylated Indolo[1,2-a]quinolines

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(16), С. 11712 - 11727

Опубликована: Авг. 2, 2023

A convenient and efficient visible-light-induced method has been developed for the construction of sulfonated selenylated indolo[1,2-a]quinolines through sulfonyl or selenyl radical-initiated tandem cyclization unactivated alkynes with sodium sulfinates diaryl diselenides under mild conditions. This protocol, which simply utilizes visible light as safe eco-friendly energy source an inexpensive nontoxic organic dye a photocatalyst without aid external photocatalyst, provides various sulfonyl- selenyl-containing in moderate to good yields.

Язык: Английский

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Acid-catalyzed radical tandem alkylation/cyclization of unactivated alkenes with ketones: Access to ketoalkyl-substituted quinazolinone derivatives

Tetrahedron, Год журнала: 2024, Номер 162, С. 134085 - 134085

Опубликована: Июнь 11, 2024

Язык: Английский

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Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives

Molecules, Год журнала: 2023, Номер 28(8), С. 3578 - 3578

Опубликована: Апрель 19, 2023

A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition aryldifluoromethyl radicals in situ produced from easily accessible gem-difluoroarylacetic acids to unactivated double bonds 2-allyloxybenzaldehyde was an effective route access a series 3-aryldifluoromethyl-containing chroman-4-one derivatives moderate good yields under mild reaction conditions.

Язык: Английский

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Acid-Catalyzed Radical Tandem Alkylation/Cyclization of Unactivated Alkenes with Ketones: Access to Ketoalkyl-Substituted Quinazolinone Derivatives

Опубликована: Янв. 1, 2024

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Язык: Английский

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Synthesis of Γ-Keto Sulfones Through Sulfonylation/Acylation of Alkenes Merging Nhc- and Photo-Catalysis

Опубликована: Янв. 1, 2024

Язык: Английский

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