One-Pot Sequential Synthesis of Alkenylated Dihydroquinolinones and Hexahydroacridinones in Deep Eutectic Solvent Medium DOI Creative Commons

Sundararajan Suresh,

Fazlur‐Rahman Nawaz Khan

ACS Omega, Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

The sequential synthesis of N-heterocycles from saturated ketones poses significant challenges and has rarely been reported. Herein, an efficient alkenylated dihydroquinolinones 7 hexahydroacridinones 8 is achieved 1 or 2 via dehydrogenation, cyclization, oxidation, α-alkenylation in choline chloride-based deep eutectic solvent (DES) medium. This strategy provides excellent yield low-cost, readily available starting materials under environmentally benign conditions. Furthermore, the synthesized compounds (4, 5, 7, 8) were investigated for their photophysical properties through absorption emission spectral studies.

Язык: Английский

Photoredox/NHC cooperative catalysis for alkylacylation of styrenes: An alternative method for the synthesis of γ-aminoketones DOI

Ke-Yang Yu,

Fu Cheng,

Dong-Sen Duan

и другие.

Tetrahedron Letters, Год журнала: 2025, Номер 156, С. 155450 - 155450

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

1

Cu(ii)-catalyzed synthesis of N-sulfonated quinolin-2(1H)-one-3-carboxamides DOI
Xue Chen, Sheng Fang, Quan Zhou

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Herein, we present an efficient Cu( ii )-catalyzed cascade synthesis of sulfonated 3-carboxamide quinolin-2-(1 H )-ones. Inthis paper, sulfonylhydrazides underwent unusual N–N bond cleavage and functioned as sulfamide synthons.

Язык: Английский

Процитировано

2

Carbonylative Cyclization of Biaryl Enones with Aldehydes and Oxamic Acids DOI
Chada Raji Reddy, Dattahari H. Kolgave,

Sana Fatima

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(24), С. 4901 - 4911

Опубликована: Янв. 1, 2024

An oxidative radical-promoted carbonylative cyclization strategy for the synthesis of phenanthren-9-(10

Язык: Английский

Процитировано

1

Metal-Free Synthesis of Pharmaceutically Relevant Sulfonylureas via Direct Reaction of Sulfonamides with Amides DOI

Sahil Mondal,

Rakhi Sati,

Muhammed F. Hashim

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(18), С. 13179 - 13191

Опубликована: Авг. 28, 2024

A metal-free process has been developed for the sustainable synthesis of medicinally important sulfonylureas in one pot via direct reaction sulfonamides with amides green solvent (DMC). The proceeded efficiently at room temperature, and products were obtained good to excellent yields. use readily accessible, inexpensive, environmentally benign starting materials reagents, mild conditions, wide substrate scope, tolerance air moisture, operational simplicity, atom economy are salient features this protocol. Gram-scale antidiabetic drugs tolbutamide chlorpropamide yields further revealed practical utility procedure. Additionally, synthetic value straightforward method is showcased by late-stage modification drug molecules, including drug-drug conjugation Preliminary mechanistic studies indicated

Язык: Английский

Процитировано

1

Synthesis of succinyldiamides containing all-quaternary carbon center by photo-induced amidation/smiles rearrangement of alkenes DOI
Yuyu Dai, Wei Niu, Jiapeng Huang

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

A novel, mild, and environmentally friendly method was developed for the synthesis of quaternary-carbon-containing succinyldiamides. This found to be compatible with many substrates.

Язык: Английский

Процитировано

1

One-Pot Sequential Synthesis of Alkenylated Dihydroquinolinones and Hexahydroacridinones in Deep Eutectic Solvent Medium DOI Creative Commons

Sundararajan Suresh,

Fazlur‐Rahman Nawaz Khan

ACS Omega, Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

The sequential synthesis of N-heterocycles from saturated ketones poses significant challenges and has rarely been reported. Herein, an efficient alkenylated dihydroquinolinones 7 hexahydroacridinones 8 is achieved 1 or 2 via dehydrogenation, cyclization, oxidation, α-alkenylation in choline chloride-based deep eutectic solvent (DES) medium. This strategy provides excellent yield low-cost, readily available starting materials under environmentally benign conditions. Furthermore, the synthesized compounds (4, 5, 7, 8) were investigated for their photophysical properties through absorption emission spectral studies.

Язык: Английский

Процитировано

0