Angewandte Chemie,
Год журнала:
2023,
Номер
135(50)
Опубликована: Ноя. 8, 2023
Abstract
A
new
approach
to
the
enantiocontrolled
synthesis
of
α‐amino
ketone
derivatives
is
disclosed
by
employing
a
decarboxylative
acylation
strategy.
Thus,
when
an
acyl
chloride
and
α‐amido‐containing
redox‐active
ester
are
exposed
nickel
catalyst,
chiral
ligand,
metal
reductant,
α‐amido
ketones
produced
in
good
yield
high
ee.
The
reaction
exhibits
broad
substrate
scope,
can
be
easily
scaled
up,
applied
dramatically
simplify
several
known
structures.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(15), С. 4318 - 4342
Опубликована: Янв. 1, 2024
This
review
primarily
focuses
on
the
generation
of
aryl
radicals
via
an
electroreduction
strategy,
and
systematically
elaborates
synthetic
applications,
scope,
limitations
substrates.
Molecules,
Год журнала:
2024,
Номер
29(3), С. 569 - 569
Опубликована: Янв. 23, 2024
Radical
reactions
in
water
or
aqueous
media
are
important
for
organic
synthesis,
realizing
high-yielding
processes
under
non-toxic
and
environmentally
friendly
conditions.
This
overview
includes
(i)
a
general
introduction
to
chemistry
media,
(ii)
synthetic
approaches
in,
on,
with
as
well
heterogeneous
phases,
(iii)
of
carbon-centered
radicals
(or
deuterium
oxide)
activated
through
coordination
various
Lewis
acids,
(iv)
photocatalysis
(v)
applications
bioinspired
by
naturally
occurring
processes.
A
wide
range
chemical
strategies
different
experimental
conditions
have
been
reviewed
that
lead
functional
group
translocation
transformation
reactions,
leading
the
preparation
complex
molecules.
These
results
reveal
how
solvent/medium/reagent
radical
has
matured
over
last
two
decades,
further
discoveries
anticipated
near
future.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(48)
Опубликована: Окт. 11, 2023
Abstract
N
‐Heterocyclic
carbene
(NHC)
catalyzed
radical‐radical
reactions
have
been
proven
to
be
powerful
strategies
for
assembling
ketyl‐containing
compounds
via
single
electron
transfer
(SET)
pathway
under
either
thermal
conditions
or
photoredox
conditions.
In
this
context,
acylation
of
alkenes
radical
relay
NHC‐organocatalysis
has
also
opened
a
new
window
the
difunctionalization
construct
valuable
molecules
in
organic
synthesis.
review,
advances
and
progress
were
summarized
according
different
ways
generation
key
NHC‐bound
ketyl‐type
radicals.
Furthermore,
reaction
scopes,
limitations
mechanisms
discussed
based
on
types
catalytic
systems.
Conclusions
perspectives
put
forward
at
end.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(50)
Опубликована: Ноя. 8, 2023
A
new
approach
to
the
enantiocontrolled
synthesis
of
α-amino
ketone
derivatives
is
disclosed
by
employing
a
decarboxylative
acylation
strategy.
Thus,
when
an
acyl
chloride
and
α-amido-containing
redox-active
ester
are
exposed
nickel
catalyst,
chiral
ligand,
metal
reductant,
α-amido
ketones
produced
in
good
yield
high
ee.
The
reaction
exhibits
broad
substrate
scope,
can
be
easily
scaled
up,
applied
dramatically
simplify
several
known
structures.
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(11)
Опубликована: Апрель 11, 2024
A
mild
protocol
for
hydroacylation
of
enones
through
photosensitization
acyl
silanes
with
thioxanthone
under
blue
light
(455
nm)
irradiation
is
reported.
Brønsted
acid
used
as
a
cocatalyst
in
the
reaction.
The
versatility
method
demonstrated
inter-
and
intramolecular
product
applied
synthesizing
an
anti-HCV
agent.
Mechanistic
insights
are
also
provided
control
experiments.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(13), С. 3777 - 3799
Опубликована: Янв. 1, 2024
This
review
summarizes
the
developments
in
C–H
functionalization
of
saturated
hydrocarbons
(C
n
H
2
+2
and
C
)
through
catalytic
carbene
insertion
into
their
bonds
dated
up
to
February
2024,
based
on
categories
types
carbenes.
European Polymer Journal,
Год журнала:
2024,
Номер
206, С. 112799 - 112799
Опубликована: Янв. 24, 2024
Trees
of
the
genus
Sterculia
produce
acidic
polysaccharides
with
high
viscosity
and
ability
to
form
gels
in
water.
This
work
emphasized
species
striata
uses
its
plant
derivatives,
such
as
seeds,
fruits,
stem
bark,
exudates.
The
showed
prospects
for
industrial
application
(seeds
protein
content,
fruits
antioxidant
potential,
bark
anti-inflammatory,
antinociceptive,
gastroprotective
potential).
From
a
physicochemical
rheological
point
view,
exudate
has
molar
mass
value;
it
contains
uronic
acid,
galactose,
rhamnose,
xylose.
gum
(SSG)
is
highly
viscous
solution
can
thermoreversible
where
gelation
conditions
depend
on
purification
method,
acetyl
groups,
presence
salt.
Due
carboxylic
acid
polyanionic
behaving
SSG
allow
formation
polyelectrolyte
complexes,
which
have
been
used
drug
delivery
systems
(DDS)
encapsulate
drugs
antimalarial
drugs,
improve
essential
oil
stability
obtain
films
antimicrobial
purposes.
review
contributes
understanding
use
this
biomaterial,
providing
basis
new
research
different
applications
use,
focus
pharmaceutical,
medical,
food,
environmental
fields.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(18)
Опубликована: Апрель 13, 2023
Abstract
A
photocatalytic
acyl
lactonization
of
unsaturated
carboxylic
acids
using
simple
and
inexpensive
chlorides
has
been
developed
for
a
modular
synthesis
lactones.
Significantly,
the
protocol
could
allow
an
efficient
construction
biologically
important
phthalide
framework.
The
transformation
be
extended
to
wide
variety
acids,
including
substituted
2‐vinyl
benzoic
different
types
alkenoic
acids.
Moreover,
series
aroyl,
heteroaroyl
serve
as
coupling
partners.
Notably,
functional
groups
MeO,
F,
Cl
Br
survive.
It
is
believed
that
radicals
generated
from
under
photoredox
catalysis
reacted
with
alkenes
via
atom‐transfer
radical
addition
(ATRA)
triggered
subsequent
in
process.
Preliminary
mechanistic
investigations
revealed
probably
proceeded
through
free
pathway.
