Methyl 2-[(Z)-5-methyl-2-oxoindolin-3-ylidene]hydrazinecarbodithioate DOI Creative Commons
Mohd Abdul Fatah Abdul Manan, David B. Cordes, Aidan P. McKay

и другие.

IUCrData, Год журнала: 2024, Номер 9(10)

Опубликована: Окт. 8, 2024

The title di-thio-carbazate imine, C

Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges DOI
Alia Mushtaq,

Uzma Azam,

Saba Mehreen

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 249, С. 115119 - 115119

Опубликована: Янв. 17, 2023

Язык: Английский

Процитировано

114
Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes DOI Creative Commons

Faiz Talab,

Saeed Ullah, Aftab Alam

и другие.

ACS Omega, Год журнала: 2023, Номер 8(7), С. 6234 - 6243

Опубликована: Фев. 8, 2023

Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch reaction in excellent yields by treating 3,5-dibromo-4-hydroxybenzaldehyde, dimedone, ammonium acetate, and ethyl acetoacetate ethanol solvent. The structures of the compounds deduced different spectroscopic techniques such as 1H NMR, 13C HR-ESI-MS. products tested for their α-glucosidase inhibitory activity where 11 (IC50= 0.56 ± 0.01 μM), 10 0.94 4 1.47 2 2.20 0.03 6 12 2.22 0.07 7 2.76 0.04 9 2.78 3 2.88 0.05 μM) exhibited high potential inhibition α-glucosidase, while rest (8, 5, 14, 15, 13) showed significant with IC50 values 3.13 0.10, 3.34 0.06, 4.27 0.13, 6.34 0.15, 21.37 0.61 μM, respectively. Among series, two compounds, i.e., 10, potent higher than standard. All compared standard drug "acarbose" (IC50 = 873.34 1.67 μM). An silico method was used to predict mode binding within active site enzyme understand mechanism inhibition. Our observation complements experimental results.

Язык: Английский

Процитировано

32
Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies DOI Creative Commons
Alia Mushtaq,

Rabbia Asif,

Waqar Ahmed Humayun

и другие.

RSC Advances, Год журнала: 2024, Номер 14(20), С. 14051 - 14067

Опубликована: Янв. 1, 2024

Synthesis of mono- and bis-thiosemicarbazones 4a–h 5a–h isatin–triazole hybrids 3a 3b in turn accessed via CuAAC, their DFT studies potential as phosphoinositide 3-kinase (PI3K) inhibitors has been evaluated this study.

Язык: Английский

Процитировано

11
Design, synthesis, characterization and biological screening of novel thiosemicarbazones and their derivatives with potent antibacterial and antidiabetic activities DOI

Waseem Shoukat,

Mazhar Hussain,

Awais Ali

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер 1320, С. 139614 - 139614

Опубликована: Авг. 18, 2024

Язык: Английский

Процитировано

9
Pyrano[2,3-b]chromone derivatives as novel dual inhibitors of α-glucosidase and α-amylase: Design, synthesis, biological evaluation, and in silico studies DOI

Elnaz Farzaneh,

Mohammad Hossein Mohammadi,

Pooya Raymand

и другие.

Bioorganic Chemistry, Год журнала: 2024, Номер 145, С. 107207 - 107207

Опубликована: Фев. 15, 2024

Язык: Английский

Процитировано

8
Arylureidoaurones: Synthesis, in vitro α-glucosidase, and α-amylase inhibition activity DOI

Mohammad Kazempour-Dizaji,

Somayeh Mojtabavi, Arash Sadri

и другие.

Bioorganic Chemistry, Год журнала: 2023, Номер 139, С. 106709 - 106709

Опубликована: Июль 1, 2023

Язык: Английский

Процитировано

17
Synthesis of new diphenyl urea-clubbed imine analogs and its Implications in diabetic management through in vitro and in silico approaches DOI Creative Commons

Anam Rubbab Pasha,

Ajmal Khan, Saeed Ullah

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Фев. 1, 2023

Abstract Type II diabetes mellitus (T2DM) is a global health issue with high rate of prevalence. The inhibition α -glucosidase enzyme has prime importance in the management T2DM. This study was established to synthesize Schiff bases 1,3-dipheny urea ( 3a–y ) and investigate their vitro anti-diabetic capability via inhibiting -glucosidase, key player catabolism carbohydrates. structures all compounds were confirmed through various techniques including, Fourier-transform infrared spectroscopy (FTIR) nuclear magnetic resonance (NMR) mass-spectrometry (MS) methods. Interestingly these displayed potent IC 50 values range 2.14–115 µM as compared acarbose used control. Additionally, docked at active site predict mode binding. docking results indicates that Glu277 Asn350 play important role stabilization enzyme. These molecules showed excellent predicted pharmacokinetics, physicochemical drug-likeness profile. potential signifies medical provide insights into prospective therapeutic options for treatment

Язык: Английский

Процитировано

14
4-Phenylthiazol-1,2,3-triazole derivatives as new potential α-glucosidase and α-amylase inhibitors DOI

Mehdi Ghanbarlou,

Somaye Karimian, Fatemeh Doraghi

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141919 - 141919

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Development of coumarin tagged 1,2,3-triazole derivatives targeting α-glucosidase inhibition: Synthetic modification, biological evaluation, kinetic and in silico studies DOI

Marzieh Aghaei Khouzani,

Mehdi Mogharabi‐Manzari, Mohammad Ali Faramarzi

и другие.

Journal of Molecular Structure, Год журнала: 2023, Номер 1282, С. 135194 - 135194

Опубликована: Фев. 20, 2023

Язык: Английский

Процитировано

11
Probing the biological activity of isatin derivatives against human lung cancer A549 cells: Cytotoxicity, CT-DNA/BSA binding, DFT/TD-DFT, topology, ADME-Tox, docking and dynamic simulations DOI
Mehran Feizi‐Dehnayebi, Ghodsi Mohammadi Ziarani, T.N. Lohith

и другие.

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127475 - 127475

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0