Abstract
The
C10a‐acetoxylated
tetrahydroazepino[1,2‐
a
]indole‐6,11‐diones
are
class
of
tricyclic
oxindoles
that
feature
an
α‐keto‐
N
,
O
‐acetal
substructure,
rendering
them
highly
susceptible
to
SET
reduction
followed
by
fragmentation.
In
protic
medium,
they
undergo
PCET‐assisted
two‐step
including
interposed
C−O
bond
cleavage
can
be
initiated
photocatalytically
as
well
cathodic
reduction,
and
which
generates
nucleophilic
ketyl
radicals.
the
presence
acrylonitrile
DIPEA
additional
reactants,
photoinduced
reaction
unfolds
tandem
reduction/ketyl
radical
conjugate
addition,
furnish
C10a‐reduced,
C11‐cyanoethyl‐substituted
azepino‐[1,2‐
]indole
derivatives
with
high
stereoselectivity.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июль 17, 2023
Abstract
Increased
energy
consumption
as
a
result
of
population
growth
and
industrialization
necessitates
the
use
renewable
sources
in
field
chemistry.
Nonrenewable
release
not
only
greenhouse
gases
but
also
other
hazardous
pollutants
that
are
damaging
to
all
living
things.
This
plainly
mandates
researchers'
source
is
both
environmentally
friendly
cost-effective.
study
shows
(sunlight)
can
be
used
synthesize
tetrahydrobenzo[
b
]pyran
scaffolds
using
Knoevenagel–Michael
cyclocondensation
aldehyde
derivatives,
malononitrile,
dimedone
via
three-condensation
domino
reaction.
research
establishes
new
role
for
solar
synthesis
under
catalyst-solvent-free
conditions,
with
outstanding
yields,
shorter
reaction
time,
great
atom
economy.
cyclization
may
done
on
gram
scale
free,
safe,
clean
from
concentrated
radiation
(CSR),
indicating
reaction's
potential
industrial
applications.
Synthetic Communications,
Год журнала:
2023,
Номер
53(22), С. 1918 - 1934
Опубликована: Сен. 7, 2023
This
article
describes
the
synthesis
of
iron
oxide/hydroxyapatite
(Fe3O4/HAp)
nanocomposite
by
hydrothermal
method
and
utilization
Fe3O4/HAp
as
a
competent,
reusable,
magnetically
separable
nano-composite
catalyst
for
one-pot
3,4-dihydropyrimidin-2(1H)-one
derivatives
cyclo-condensation
dicarbonyl
compound,
aryl-aldehydes
(thio)urea
in
EtOH:H2O
(1:1,
v/v)
an
eco-safe
solvent.
The
nano-catalyst
was
characterized
spectral
analytical
techniques
such
FT-IR,
SEM,
XRD,
EDX
VSM.
advantage
this
procedure
includes
excellent
product
yield
shorter
time,
simple
workup
procedure,
reusability
catalyst,
avoidance
volatile
organic
solvent,
strong
mineral
acid.
Archiv der Pharmazie,
Год журнала:
2023,
Номер
356(6)
Опубликована: Март 10, 2023
Abstract
The
Biginelli
reaction
has
received
significant
consideration
in
recent
years
due
to
its
easily
accessible
aldehyde,
urea/thiourea,
and
active
methylene
compounds.
When
it
comes
pharmacological
applications,
the
end‐products,
2‐oxo‐1,2,3,4‐tetrahydropyrimidines,
are
vital
applications.
Due
ease
of
carrying
out
reaction,
offers
a
number
exciting
prospects
various
fields.
Catalysts,
however,
play
an
essential
role
Biginelli's
reaction.
In
absence
catalyst,
is
difficult
form
products
with
good
yield.
Many
catalysts
have
been
used
search
efficientmethodologies,
including
biocatalysts,
Brønsted/Lewis
acids,
heterogeneous
catalysts,
organocatalysts,
so
on.
Nanocatalysts
currently
being
applied
improve
environmental
profile
as
well
speed
up
process.
This
review
describes
catalytic
application
2‐oxo/thioxo‐1,2,3,4‐tetrahydropyrimidines.
study
provides
information
that
will
facilitate
development
newer
methods
for
by
academics
industrialists.
It
also
broad
scope
drug
design
strategies,
which
may
enable
novel
highly
effective
bioactive
molecules.
Catalysis Science & Technology,
Год журнала:
2024,
Номер
14(19), С. 5755 - 5763
Опубликована: Янв. 1, 2024
A
green
and
scalable
heterogeneous
photocatalysis
platform
is
efficiently
established
for
multigram
juglone
production
using
photomicroreactors,
which
are
at
the
forefront
of
sustainable
flow
chemistry.
Photochemistry and Photobiology,
Год журнала:
2024,
Номер
100(6), С. 1773 - 1786
Опубликована: Июнь 28, 2024
Elevated
global
pollution
level
is
the
prime
reason
that
contributes
to
onset
of
various
harmful
health
diseases.
The
products
Biginelli
reaction
are
enormously
used
in
pharmaceutical
industry
as
they
have
antiviral,
antibacterial,
and
calcium
channel
modulation
abilities.
This
work
reports
a
novel
eosin
Y
sensitized
boron
graphitic
carbon
nitride
(EY-B
Herein,
we
report
the
use
of
isonitriles
as
alkyl
radical
precursors
in
light-mediated
hydro-
and
deuterodeamination
reactions.
The
reaction
is
scalable,
shows
broad
functional
group
compatibility
potential
to
be
used
late-stage
functionalization.
Importantly,
method
general
for
Cα-1º,
Cα-2º
Cα-3º
isonitriles.
For
most
examples,
high
yields
were
obtained
through
direct
visible-light
irradiation
isonitrile
presence
a
silyl
precursor.
Interestingly,
an
organic
photocatalyst
(4CzIPN)
dramatic
acceleration
was
observed.
In
depth
mechanistic
studies
using
UV-vis
absorption,
steady-state
time-resolved
photoluminescence,
transient
absorption
spectroscopy
suggest
that
excited
state
4CzIPN
able
sensitize
single
electron
transfer.
Angewandte Chemie,
Год журнала:
2023,
Номер
136(7)
Опубликована: Дек. 27, 2023
Abstract
Herein,
we
report
the
use
of
isonitriles
as
alkyl
radical
precursors
in
light‐mediated
hydro‐
and
deuterodeamination
reactions.
The
reaction
is
scalable,
shows
broad
functional
group
compatibility
potential
to
be
used
late‐stage
functionalization.
Importantly,
method
general
for
C
α
‐primary,
‐secondary
‐tertiary
isonitriles.
For
most
examples,
high
yields
were
obtained
through
direct
visible‐light
irradiation
isonitrile
presence
a
silyl
precursor.
Interestingly,
an
organic
photocatalyst
(4CzIPN)
dramatic
acceleration
was
observed.
In‐depth
mechanistic
studies
using
UV/Vis
absorption,
steady‐state
time‐resolved
photoluminescence,
transient
absorption
spectroscopy
suggest
that
excited
state
4CzIPN
can
engage
single‐electron
transfer
with
isonitrile.
Abstract
The
C10a‐acetoxylated
tetrahydroazepino[1,2‐
a
]indole‐6,11‐diones
are
class
of
tricyclic
oxindoles
that
feature
an
α‐keto‐
N
,
O
‐acetal
substructure,
rendering
them
highly
susceptible
to
SET
reduction
followed
by
fragmentation.
In
protic
medium,
they
undergo
PCET‐assisted
two‐step
including
interposed
C−O
bond
cleavage
can
be
initiated
photocatalytically
as
well
cathodic
reduction,
and
which
generates
nucleophilic
ketyl
radicals.
the
presence
acrylonitrile
DIPEA
additional
reactants,
photoinduced
reaction
unfolds
tandem
reduction/ketyl
radical
conjugate
addition,
furnish
C10a‐reduced,
C11‐cyanoethyl‐substituted
azepino‐[1,2‐
]indole
derivatives
with
high
stereoselectivity.
