ChemPhotoChem,
Journal Year:
2024,
Volume and Issue:
8(8)
Published: March 12, 2024
Abstract
The
C10a‐acetoxylated
tetrahydroazepino[1,2‐
a
]indole‐6,11‐diones
are
class
of
tricyclic
oxindoles
that
feature
an
α‐keto‐
N
,
O
‐acetal
substructure,
rendering
them
highly
susceptible
to
SET
reduction
followed
by
fragmentation.
In
protic
medium,
they
undergo
PCET‐assisted
two‐step
including
interposed
C−O
bond
cleavage
can
be
initiated
photocatalytically
as
well
cathodic
reduction,
and
which
generates
nucleophilic
ketyl
radicals.
the
presence
acrylonitrile
DIPEA
additional
reactants,
photoinduced
reaction
unfolds
tandem
reduction/ketyl
radical
conjugate
addition,
furnish
C10a‐reduced,
C11‐cyanoethyl‐substituted
azepino‐[1,2‐
]indole
derivatives
with
high
stereoselectivity.
Synthetic Communications,
Journal Year:
2023,
Volume and Issue:
53(22), P. 1918 - 1934
Published: Sept. 7, 2023
This
article
describes
the
synthesis
of
iron
oxide/hydroxyapatite
(Fe3O4/HAp)
nanocomposite
by
hydrothermal
method
and
utilization
Fe3O4/HAp
as
a
competent,
reusable,
magnetically
separable
nano-composite
catalyst
for
one-pot
3,4-dihydropyrimidin-2(1H)-one
derivatives
cyclo-condensation
dicarbonyl
compound,
aryl-aldehydes
(thio)urea
in
EtOH:H2O
(1:1,
v/v)
an
eco-safe
solvent.
The
nano-catalyst
was
characterized
spectral
analytical
techniques
such
FT-IR,
SEM,
XRD,
EDX
VSM.
advantage
this
procedure
includes
excellent
product
yield
shorter
time,
simple
workup
procedure,
reusability
catalyst,
avoidance
volatile
organic
solvent,
strong
mineral
acid.
Archiv der Pharmazie,
Journal Year:
2023,
Volume and Issue:
356(6)
Published: March 10, 2023
Abstract
The
Biginelli
reaction
has
received
significant
consideration
in
recent
years
due
to
its
easily
accessible
aldehyde,
urea/thiourea,
and
active
methylene
compounds.
When
it
comes
pharmacological
applications,
the
end‐products,
2‐oxo‐1,2,3,4‐tetrahydropyrimidines,
are
vital
applications.
Due
ease
of
carrying
out
reaction,
offers
a
number
exciting
prospects
various
fields.
Catalysts,
however,
play
an
essential
role
Biginelli's
reaction.
In
absence
catalyst,
is
difficult
form
products
with
good
yield.
Many
catalysts
have
been
used
search
efficientmethodologies,
including
biocatalysts,
Brønsted/Lewis
acids,
heterogeneous
catalysts,
organocatalysts,
so
on.
Nanocatalysts
currently
being
applied
improve
environmental
profile
as
well
speed
up
process.
This
review
describes
catalytic
application
2‐oxo/thioxo‐1,2,3,4‐tetrahydropyrimidines.
study
provides
information
that
will
facilitate
development
newer
methods
for
by
academics
industrialists.
It
also
broad
scope
drug
design
strategies,
which
may
enable
novel
highly
effective
bioactive
molecules.
Photochemistry and Photobiology,
Journal Year:
2024,
Volume and Issue:
100(6), P. 1773 - 1786
Published: June 28, 2024
Elevated
global
pollution
level
is
the
prime
reason
that
contributes
to
onset
of
various
harmful
health
diseases.
The
products
Biginelli
reaction
are
enormously
used
in
pharmaceutical
industry
as
they
have
antiviral,
antibacterial,
and
calcium
channel
modulation
abilities.
This
work
reports
a
novel
eosin
Y
sensitized
boron
graphitic
carbon
nitride
(EY-B
Catalysis Science & Technology,
Journal Year:
2024,
Volume and Issue:
14(19), P. 5755 - 5763
Published: Jan. 1, 2024
A
green
and
scalable
heterogeneous
photocatalysis
platform
is
efficiently
established
for
multigram
juglone
production
using
photomicroreactors,
which
are
at
the
forefront
of
sustainable
flow
chemistry.
Herein,
we
report
the
use
of
isonitriles
as
alkyl
radical
precursors
in
light-mediated
hydro-
and
deuterodeamination
reactions.
The
reaction
is
scalable,
shows
broad
functional
group
compatibility
potential
to
be
used
late-stage
functionalization.
Importantly,
method
general
for
Cα-1º,
Cα-2º
Cα-3º
isonitriles.
For
most
examples,
high
yields
were
obtained
through
direct
visible-light
irradiation
isonitrile
presence
a
silyl
precursor.
Interestingly,
an
organic
photocatalyst
(4CzIPN)
dramatic
acceleration
was
observed.
In
depth
mechanistic
studies
using
UV-vis
absorption,
steady-state
time-resolved
photoluminescence,
transient
absorption
spectroscopy
suggest
that
excited
state
4CzIPN
able
sensitize
single
electron
transfer.
Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
136(7)
Published: Dec. 27, 2023
Abstract
Herein,
we
report
the
use
of
isonitriles
as
alkyl
radical
precursors
in
light‐mediated
hydro‐
and
deuterodeamination
reactions.
The
reaction
is
scalable,
shows
broad
functional
group
compatibility
potential
to
be
used
late‐stage
functionalization.
Importantly,
method
general
for
C
α
‐primary,
‐secondary
‐tertiary
isonitriles.
For
most
examples,
high
yields
were
obtained
through
direct
visible‐light
irradiation
isonitrile
presence
a
silyl
precursor.
Interestingly,
an
organic
photocatalyst
(4CzIPN)
dramatic
acceleration
was
observed.
In‐depth
mechanistic
studies
using
UV/Vis
absorption,
steady‐state
time‐resolved
photoluminescence,
transient
absorption
spectroscopy
suggest
that
excited
state
4CzIPN
can
engage
single‐electron
transfer
with
isonitrile.
ChemPhotoChem,
Journal Year:
2024,
Volume and Issue:
8(8)
Published: March 12, 2024
Abstract
The
C10a‐acetoxylated
tetrahydroazepino[1,2‐
a
]indole‐6,11‐diones
are
class
of
tricyclic
oxindoles
that
feature
an
α‐keto‐
N
,
O
‐acetal
substructure,
rendering
them
highly
susceptible
to
SET
reduction
followed
by
fragmentation.
In
protic
medium,
they
undergo
PCET‐assisted
two‐step
including
interposed
C−O
bond
cleavage
can
be
initiated
photocatalytically
as
well
cathodic
reduction,
and
which
generates
nucleophilic
ketyl
radicals.
the
presence
acrylonitrile
DIPEA
additional
reactants,
photoinduced
reaction
unfolds
tandem
reduction/ketyl
radical
conjugate
addition,
furnish
C10a‐reduced,
C11‐cyanoethyl‐substituted
azepino‐[1,2‐
]indole
derivatives
with
high
stereoselectivity.
