Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 247, С. 114419 - 114419
Опубликована: Ноя. 30, 2024
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(27)
Опубликована: Июнь 2, 2024
Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.
Язык: Английский
Процитировано
31
Discover Materials, Год журнала: 2025, Номер 5(1)
Опубликована: Янв. 9, 2025
Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.
Язык: Английский
Процитировано
12
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106698 - 106698
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133465 - 133465
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
16
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
Sprayable hydrogels have emerged as a transformative innovation in biomedical technology, offering versatile, efficient, and minimally invasive platform for various clinical applications. They form gels situ upon tissue contact, enabling seamless application on even complex surfaces. This property is especially useful wound care, drug delivery, engineering, where localized sustained release of therapeutics essential. Formulations can be customized to include bioactive compounds, such growth factors, antibiotics, anti-inflammatory agents, thereby enhancing targeted treatment outcomes. review delves into the fundamental principles governing sprayable hydrogels, emphasizing critical mechanisms cross-linking, shear-thinning properties, thermoresponsive behavior. Furthermore, it highlights recent advancements since 2020, including strategic incorporation agents augment therapeutic efficacy. By examining these core design strategies, this provides comprehensive perspective engineering modern medical
Язык: Английский
Процитировано
1
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114545 - 114545
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Current Opinion in Colloid & Interface Science, Год журнала: 2024, Номер 73, С. 101847 - 101847
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
8
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105607 - 105607
Опубликована: Март 22, 2024
Язык: Английский
Процитировано
5
European Polymer Journal, Год журнала: 2024, Номер 218, С. 113347 - 113347
Опубликована: Июль 28, 2024
Язык: Английский
Процитировано
5
Biomaterials Research, Год журнала: 2024, Номер 28
Опубликована: Янв. 1, 2024
The abdominal wall plays a crucial role in safeguarding the internal organs of body, serving as an essential protective barrier. Defects are common due to surgery, infection, or trauma. Complex defects have limited self-healing capacity and require external intervention. Traditional treatments drawbacks, biomaterials not fully achieved desired outcomes. Hydrogel has emerged promising strategy that is extensively studied applied promoting tissue regeneration by filling repairing damaged its unique properties. This review summarizes five prominent properties advances using hydrogels enhance healing repair defects: (a) good biocompatibility with host tissues reduces adverse reactions immune responses while supporting cell adhesion migration proliferation; (b) tunable mechanical matching those adapt normal movement deformations reducing stress, thereby influencing regulating behavior regeneration; (c) drug carriers continuously delivering drugs bioactive molecules sites optimizing processes enhancing (d) promotion interactions simulating hydrated extracellular matrix environments, providing physical support, space, cues for migration, adhesion, (e) easy manipulation application surgical procedures, allowing precise placement close defective wall, support. Additionally, also mentioned. Finally, overview provided on current obstacles constraints faced hydrogels, along potential prospects defects.
Язык: Английский
Процитировано
4