Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: June 2, 2024

Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.

Language: Английский

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Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications

Discover Materials, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 9, 2025

Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.

Language: Английский

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O-carboxymethyl chitosan in biomedicine: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133465 - 133465

Published: June 28, 2024

Language: Английский

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Advancements in Protein-Based Bionanocomposites for Targeted and Controlled Drug Delivery Systems: A Comprehensive Review

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

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Unveiling the Diverse Principles for Developing Sprayable Hydrogels for Biomedical Applications

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Sprayable hydrogels have emerged as a transformative innovation in biomedical technology, offering versatile, efficient, and minimally invasive platform for various clinical applications. They form gels situ upon tissue contact, enabling seamless application on even complex surfaces. This property is especially useful wound care, drug delivery, engineering, where localized sustained release of therapeutics essential. Formulations can be customized to include bioactive compounds, such growth factors, antibiotics, anti-inflammatory agents, thereby enhancing targeted treatment outcomes. review delves into the fundamental principles governing sprayable hydrogels, emphasizing critical mechanisms cross-linking, shear-thinning properties, thermoresponsive behavior. Furthermore, it highlights recent advancements since 2020, including strategic incorporation agents augment therapeutic efficacy. By examining these core design strategies, this provides comprehensive perspective engineering modern medical

Language: Английский

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Colon-targeted dual-coating MOF nanoparticles for the delivery of curcumin with anti-inflammatory properties in the treatment of ulcerative colitis

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114545 - 114545

Published: Feb. 1, 2025

Language: Английский

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Applications of Artificial Intelligence and Machine Learning on Critical Materials Used in Cosmetics and Personal Care Formulation Design

Current Opinion in Colloid & Interface Science, Journal Year: 2024, Volume and Issue: 73, P. 101847 - 101847

Published: Aug. 3, 2024

Language: Английский

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Microbial assistance in nano-carrier development: Innovative strategies in drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105607 - 105607

Published: March 22, 2024

Language: Английский

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Integration of molybdenum disulfide and phosphorene into polymeric-based nanocomposite hydrogels for various biomedical applications: Recent advances and future prospects

European Polymer Journal, Journal Year: 2024, Volume and Issue: 218, P. 113347 - 113347

Published: July 28, 2024

Language: Английский

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Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

The abdominal wall plays a crucial role in safeguarding the internal organs of body, serving as an essential protective barrier. Defects are common due to surgery, infection, or trauma. Complex defects have limited self-healing capacity and require external intervention. Traditional treatments drawbacks, biomaterials not fully achieved desired outcomes. Hydrogel has emerged promising strategy that is extensively studied applied promoting tissue regeneration by filling repairing damaged its unique properties. This review summarizes five prominent properties advances using hydrogels enhance healing repair defects: (a) good biocompatibility with host tissues reduces adverse reactions immune responses while supporting cell adhesion migration proliferation; (b) tunable mechanical matching those adapt normal movement deformations reducing stress, thereby influencing regulating behavior regeneration; (c) drug carriers continuously delivering drugs bioactive molecules sites optimizing processes enhancing (d) promotion interactions simulating hydrated extracellular matrix environments, providing physical support, space, cues for migration, adhesion, (e) easy manipulation application surgical procedures, allowing precise placement close defective wall, support. Additionally, also mentioned. Finally, overview provided on current obstacles constraints faced hydrogels, along potential prospects defects.

Language: Английский

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