Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products
Biomaterials,
Год журнала:
2024,
Номер
312, С. 122718 - 122718
Опубликована: Июль 27, 2024
Functional
hydrogels
are
used
for
numerous
biomedical
applications
such
as
tissue
engineering,
wound
dressings,
lubricants,
contact
lenses
and
advanced
drug
delivery
systems.
Most
of
them
based
on
synthetic
or
natural
polymers
forming
a
three-dimensional
network
that
contains
aqueous
media.
Among
polymers,
poly(meth)acrylates,
polyethyleneglycols,
poly(vinylalcohols),
poly(vinylpyrrolidones),
PLGA
poly(urethanes)
high
relevance,
whereas
mainly
polysaccharides
hyaluronic
acid,
alginate
chitosan
proteins
albumin,
collagen
elastin.
In
contrast
to
most
biodegradable.
Both
often
chemically
modified
in
order
improve
induce
favorable
properties
functions
like
mechanical
strength,
stiffness,
elasticity,
porosity,
adhesive
properties,
situ
gelling
water
binding
capacity
release
controlling
properties.
Within
this
review
we
provide
an
overview
about
the
broad
spectrum
functional
hydrogels,
summarize
innovative
approaches,
discuss
concept
relevant
clinical
trials
highlight
products
examples
successful
developments.
Язык: Английский
Bioactive microgel-coated electrospun membrane with cell-instructive interfaces and topology for abdominal wall defect repair
Renquan Xing,
Rui Gao,
Yini Huangfu
и другие.
Biomaterials Science,
Год журнала:
2024,
Номер
12(11), С. 2930 - 2942
Опубликована: Янв. 1, 2024
A
promising
bioactive
microgel-coated
electrospun
membrane
with
cell-instructive
interfaces
and
topology
for
abdominal
wall
defect
repair.
Язык: Английский
Fabrication of oxygen-releasing dextran microgels by droplet-based microfluidic method
RSC Advances,
Год журнала:
2024,
Номер
14(36), С. 26544 - 26555
Опубликована: Янв. 1, 2024
Dextran-based
microgels
with
controllable
oxygen
releasing
property
were
fabricated
using
droplet-based
microfluidic
system.
Язык: Английский
Gel-Based Suspension Medium Used in 3D Bioprinting for Constructing Tissue/Organ Analogs
Gels,
Год журнала:
2024,
Номер
10(10), С. 644 - 644
Опубликована: Окт. 10, 2024
Constructing
tissue/organ
analogs
with
natural
structures
and
cell
types
in
vitro
offers
a
valuable
strategy
for
the
situ
repair
of
damaged
tissues/organs.
Three-dimensional
(3D)
bioprinting
is
flexible
method
fabricating
these
analogs.
However,
extrusion-based
3D
faces
challenge
balancing
use
soft
bioinks
need
high-fidelity
geometric
shapes.
To
address
challenges,
recent
advancements
have
introduced
various
suspension
mediums
based
on
gelatin,
agarose,
gellan
gum
microgels.
The
emergence
gel-based
has
significantly
advanced
fabrication
constructs
using
bioprinting.
They
effectively
stabilize
support
bioinks,
enabling
formation
complex
spatial
geometries.
Moreover,
they
provide
stable,
cell-friendly
environment
that
maximizes
viability
during
printing
process.
This
minireview
will
summarize
properties,
preparation
methods,
potential
applications
constructing
analogs,
while
also
addressing
current
challenges
providing
an
outlook
future
Язык: Английский