Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122718 - 122718

Published: July 27, 2024

Functional hydrogels are used for numerous biomedical applications such as tissue engineering, wound dressings, lubricants, contact lenses and advanced drug delivery systems. Most of them based on synthetic or natural polymers forming a three-dimensional network that contains aqueous media. Among polymers, poly(meth)acrylates, polyethyleneglycols, poly(vinylalcohols), poly(vinylpyrrolidones), PLGA poly(urethanes) high relevance, whereas mainly polysaccharides hyaluronic acid, alginate chitosan proteins albumin, collagen elastin. In contrast to most biodegradable. Both often chemically modified in order improve induce favorable properties functions like mechanical strength, stiffness, elasticity, porosity, adhesive properties, situ gelling water binding capacity release controlling properties. Within this review we provide an overview about the broad spectrum functional hydrogels, summarize innovative approaches, discuss concept relevant clinical trials highlight products examples successful developments.

Language: Английский

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Bioactive microgel-coated electrospun membrane with cell-instructive interfaces and topology for abdominal wall defect repair

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(11), P. 2930 - 2942

Published: Jan. 1, 2024

A promising bioactive microgel-coated electrospun membrane with cell-instructive interfaces and topology for abdominal wall defect repair.

Language: Английский

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Gel-Based Suspension Medium Used in 3D Bioprinting for Constructing Tissue/Organ Analogs

Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 644 - 644

Published: Oct. 10, 2024

Constructing tissue/organ analogs with natural structures and cell types in vitro offers a valuable strategy for the situ repair of damaged tissues/organs. Three-dimensional (3D) bioprinting is flexible method fabricating these analogs. However, extrusion-based 3D faces challenge balancing use soft bioinks need high-fidelity geometric shapes. To address challenges, recent advancements have introduced various suspension mediums based on gelatin, agarose, gellan gum microgels. The emergence gel-based has significantly advanced fabrication constructs using bioprinting. They effectively stabilize support bioinks, enabling formation complex spatial geometries. Moreover, they provide stable, cell-friendly environment that maximizes viability during printing process. This minireview will summarize properties, preparation methods, potential applications constructing analogs, while also addressing current challenges providing an outlook future

Language: Английский

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Fabrication of oxygen-releasing dextran microgels by droplet-based microfluidic method

RSC Advances, Journal Year: 2024, Volume and Issue: 14(36), P. 26544 - 26555

Published: Jan. 1, 2024

Dextran-based microgels with controllable oxygen releasing property were fabricated using droplet-based microfluidic system.

Language: Английский

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