Synthesis of Diverse 4‐Pyrrolin‐2‐ones by Electrochemically Induced Dehydrogenative Regioselective Cyclization of 3‐Aza‐1,5‐dienes and 1,3‐Dicarbonyl Compounds
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(11)
Опубликована: Янв. 20, 2024
Abstract
A
practical
and
mild
electrochemical
dehydrogenative
regioselective
cyclization
method
has
been
established
for
the
synthesis
of
4‐pyrrolin‐2‐ones
using
3‐aza‐1,5‐dienes
1,3‐dicarbonyl
compounds
as
substrates.
This
protocol
is
catalyst‐free,
metal‐free,
does
not
require
oxidizing
agents.
It
exhibits
wide
substrate
compatibility
can
be
easily
scaled
up
to
gram
scale.
Язык: Английский
Photoredox/nickel dual-catalysis-enabled synthesis of N-heterocycles from alkyl chlorides and alkenes
Molecular Catalysis,
Год журнала:
2024,
Номер
553, С. 113806 - 113806
Опубликована: Янв. 1, 2024
Язык: Английский
Copper-Catalyzed [3 + 2] Annulation of O-Acyl Oximes with 4-Sulfonamidophenols for the Synthesis of 5-Sulfonamidoindoles and 2-Amido-5-sulfonamidobenzofuran-3(2H)-ones
Organic Letters,
Год журнала:
2024,
Номер
26(20), С. 4229 - 4234
Опубликована: Май 13, 2024
A
copper-catalyzed
[3
+
2]
annulation
of
Язык: Английский
Iron-Catalyzed [3 + 2] Annulation of O-Acyl Oximes with 2-Hydroxy-1-Naphthoates for the Synthesis of Benzo[g]indoles
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
An
iron-catalyzed
[3
+
2]
annulation
of
O-acyl
oximes
with
2-hydroxy-1-naphthoates
has
been
developed.
This
strategy
features
the
simultaneous
activation
both
substrates
to
form
two
radical
intermediates.
Subsequent
selective
C-N
coupling
followed
by
sequential
condensation
and
1,3-ester
migration
affords
1H-
or
3H-benzo[g]indoles.
In
terms
derived
from
4-oxocyclohexanone
4-azacyclohexanone,
further
ring-opening
furnishes
2-(2-hydroxyethyl)-
2-(2-aminoethyl)-1H-benzo[g]indoles.
Язык: Английский
Iron-Catalyzed Double Annulation of O-Acyl Oximes with Fumaronitrile for the Synthesis of 4-Cyano-7-azaindoles
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 2, 2025
An
iron-catalyzed
double
annulation
of
O-acyl
oximes
with
fumaronitrile
has
been
developed
for
the
concise
synthesis
polysubstituted
4-cyano-7-azaindoles.
This
method
enables
construction
two
fused
heterocycles
in
a
one-step
reaction
using
readily
available
starting
materials
under
redox-neutral
conditions.
Язык: Английский
Copper-Catalyzed [3 + 2] Annulation of O-Acyl Oximes with p-Hydroquinones for the Synthesis of 5-Hydroxyindoles
Hui-Peng Zhang,
Wei Chen,
Zi-Jun Hu
и другие.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 4, 2024
A
copper-catalyzed
[3
+
2]
annulation
of
Язык: Английский
Photoredox/Nickel Dual-Catalysis-Enabled Regioselective Cyclization of Alkenes with Alkyl Chlorides
Опубликована: Янв. 1, 2023
A
photoredox/nickel
dual
catalysis
is
presented
for
the
construction
of
several
kinds
useful
nitrogen-containing
heterocycles.
This
protocol
regioselective
and
features
a
broad
substrate
scope.
It
provides
direct
access
to
heterocycles
by
reacting
alkyl
chlorides
with
readily
available
activated
unactivated
alkenes.
Moreover,
this
can
be
easily
scalable
gram-scale,
it
feasible
use
sunlight
as
light
source.
Mechanistic
studies
suggest
that
energy
transfer
pathway
involved
in
catalytic
process.
Язык: Английский