Rh(III)-Catalyzed, Redox-Neutral, C–H Multifluoroalkenylation of Benzamides

Synthesis, Год журнала: 2024, Номер 56(19), С. 3045 - 3053

Опубликована: Июнь 11, 2024

Abstract Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Multifluoroalkyl-containing compounds have attracted increasing attention for their unique ability to alter the activity of drugs bioactive molecules. Herein, we report an efficient Rh(III)-catalyzed, redox-neutral, C–H multifluoroalkenylation benzamides with multifluoroalkenes, which provides a versatile protocol accessing wide range multifluoroalkenylated arenes.

Язык: Английский

Divergent synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes and indole-3-methanamines

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 22(1), С. 90 - 94

Опубликована: Ноя. 24, 2023

A facile and straightforward method for the successful synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes indole-3-methanamines by a Friedel–Crafts reaction is developed.

Язык: Английский