Cobalt-Catalyzed Three-Component Assembling of Aromatic Oximes with Substituted Dienes and Formaldehyde

Chemical Communications, Год журнала: 2024, Номер 60(76), С. 10540 - 10543

Опубликована: Янв. 1, 2024

A cobalt-catalyzed three-component assembly of substituted aryl oximes with dienes and formaldehyde

Язык: Английский

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Co(III)-Catalyzed Three-Component Assembling of 2-Pyridones with Dienes and Formaldehyde via C–H Bond Activation

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Here, we have demonstrated a Co(III)-catalyzed C–H functionalization of substituted pyridones with dienes and para-formaldehyde via three-component sequential reaction. A library homoallylic alcohols is synthesized high regio- chemoselectivity. The reaction scope widely compatible various N-pyridyl-2-pyridones, butadiene, dienes. Interestingly, N-pyridyl-4-pyridone also participated in the product was further converted into dihydrofuran-derived N-pyridyl-2-pyridone derivatives. convincing mechanism mechanistic investigations are described to justify current methodology.

Язык: Английский

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C–H Activation and Sequential Addition to Dienes and Imines: Synthesis of Amines with β-Quaternary Centers and Mechanistic Studies on the Complex Interplay Between the Catalyst and Three Reactants

ACS Catalysis, Год журнала: 2024, Номер 14(23), С. 18124 - 18133

Опубликована: Ноя. 22, 2024

A Rh(III)-catalyzed sequential C-H bond addition to dienes and in situ formed aldimines was developed, allowing for the preparation of otherwise challenging access amines with quaternary centers at

Язык: Английский

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Synthesis of α-Quaternary Amides via Cp*Co(III)-Catalyzed Sequential C–H Bond Addition to 1,3-Dienes and Isocyanates

Organic Letters, Год журнала: 2024, Номер 26(45), С. 9769 - 9774

Опубликована: Окт. 31, 2024

The synthesis of sterically congested amides was accomplished via Cp*Co(III)-catalyzed sequential C–H bond addition to 1,3-dienes followed by aminocarbonylation with isocyanates, a coupling partner that had never been utilized in reactions. A variety reactants, internally substituted dienes, and aromatic isocyanates provided secondary amide products incorporating α-all-carbon quaternary centers. conversion the other useful compound classes also demonstrated.

Язык: Английский

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Co(III)-Catalyzed C6-Selective C–H Activation/Pyridine Migration of 2-Pyridones with Propiolates

Organic Letters, Год журнала: 2023, Номер unknown

Опубликована: Дек. 21, 2023

A versatile Co(III)-catalyzed C6-selective C–H activation/pyridine migration of 2-pyridones with available propiolates as coupling partners was demonstrated. This method features high atom economy, excellent regioselectivity, and good functional group tolerance by employing an inexpensive Co(III) catalyst under mild reaction conditions. Moreover, gram-scale synthesis late-stage modifications pharmaceuticals were performed to prove the effectiveness these synthetic approaches.

Язык: Английский

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Cobalt-Catalyzed C-H Functionalization of Heterocycles

Topics in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 61 - 88

Опубликована: Янв. 1, 2024

Язык: Английский

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Co-Catalyzed Three-Component Synthesis of N-Pyrimidyl Indoles

Synfacts, Год журнала: 2023, Номер 19(08), С. 0792 - 0792

Опубликована: Июль 14, 2023

Key words cobalt catalysis - C–H activation multicomponent reaction pyrimidyl indoles

Язык: Английский

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