Synthesis of 1,4‐Naphthoquinones via Palladium(II)‐Catalyzed Tertiary C−H Alkylation of Olefins Followed by C−C Bond Cleavage DOI
Xu Zhang,

Mengfan Chang,

Tongtong Ni

и другие.

European Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Abstract An efficient method has been developed for the preparation of 1,4‐naphthoquinones via a palladium‐catalyzed reaction 2‐aryl‐1,3‐indandiones with olefins. This involves tertiary C−H alkylation olefins to produce alcohol, followed by C−C bond cleavage.

Язык: Английский

Direct Access to Furan and Cyclopropane Derivatives by Palladium-Catalyzed C-H Activation/Alkenes Insertion/Annulation DOI
Xu Zhang,

Mengfan Chang,

Xuefeng Xu

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(53), С. 6769 - 6772

Опубликована: Янв. 1, 2024

A practical and effective palladium-catalyzed C-H activation/alkene insertion/annulation has been reported for the synthesis of furans cyclopropanes from cyclic 1,3-diketones or 1,3-indandione diverse alkenes, resulting in moderate to good yields. This protocol demonstrates excellent selectivity is well-compatible with a wide range alkene substrates, exhibiting exceptional regioselectivities, high efficiency, functional group tolerance.

Язык: Английский

Процитировано

3
Synthesis of the Tetracyclic Spiro-naphthoquinone Chartspiroton DOI Creative Commons

Liesa Röder,

Klaus Wurst, Thomas Magauer

и другие.

Organic Letters, Год журнала: 2024, Номер 26(15), С. 3065 - 3068

Опубликована: Апрель 1, 2024

Chartspiroton is a recently discovered naphthoquinone natural product that features spiro-fused benzofuran lactone. We report its first synthesis via an 11-step linear sequence. The sterically hindered tetra-ortho-substituted biaryl subunit was installed by base-induced ring expansion of readily available 1,3-indandione. This step also liberated the fully substituted naphthalene core unit at same time. unique lactone constructed late-stage oxidation advanced naphthoquinone.

Язык: Английский

Процитировано

2
CuBr2 Mediated Dehydrogenative [4 + 2] Annulation of 1-Naphthyl-1,3-indandiones and Alkenes DOI
Xu Zhang,

Mengfan Chang,

Tongtong Ni

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(68), С. 9070 - 9073

Опубликована: Янв. 1, 2024

Intermolecular annulation reactions of 1-naphthyl-1,3-indandiones with alkenes proceed efficiently in the presence a copper catalyst to generate spirocarbocycle compounds.

Язык: Английский

Процитировано

1
Synthesis of 1,4‐Naphthoquinones via Palladium(II)‐Catalyzed Tertiary C−H Alkylation of Olefins Followed by C−C Bond Cleavage DOI
Xu Zhang,

Mengfan Chang,

Tongtong Ni

и другие.

European Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Abstract An efficient method has been developed for the preparation of 1,4‐naphthoquinones via a palladium‐catalyzed reaction 2‐aryl‐1,3‐indandiones with olefins. This involves tertiary C−H alkylation olefins to produce alcohol, followed by C−C bond cleavage.

Язык: Английский

Процитировано

0