Synthesis of Spirocyclopropane Scaffolds: A Review
Synthesis,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 4, 2025
Abstract
This
review
highlights
different
synthetic
strategies
for
preparing
a
spirocyclopropane
moiety,
covering
the
literature
from
1989
to
2024.
The
moiety
is
structural
scaffold
that
used
access
libraries
of
highly
functionalized
spirocarbo-
and
heterocyclic
molecules.
showcases
routes
synthesis
spirocyclopropanes
utilize
distinct
precursors
methodologies,
including
cascade
reactions,
cyclopropanation,
Michael-initiated
ring
closure
(MIRC),
one-pot
multicomponent
synthesis.
These
discussions
are
organized
around
oxindole
core,
which
include
isatin,
oxindole,
3-chlorooxindole,
3-alkenyl
oxindoles.
Additionally,
this
explores
various
ylides
other
techniques.
goal
provide
background
chemistry
researchers
develop
new
ideas
novel
spirocyclopropanes.
1
Introduction
2
Synthesis
Spirocyclopropanes
3-Chlorooxindole
Derivatives
3
Isatin
3.1
Alkylidene
Oxindole
3.2
Diazooxindole
Compounds
4
1,3-Diones
5
N-Ylides
6
S-Ylides
7
Miscellaneous
Syntheses
8
Conclusion
9
List
Abbreviations
Язык: Английский
Optimization of Palladium-Catalyzed One-Pot Synthesis of Functionalized Furans for High-Yield Production: A Study of Catalytic and Reaction Parameters
Catalysts,
Год журнала:
2024,
Номер
14(10), С. 712 - 712
Опубликована: Окт. 11, 2024
This
study
investigates
the
palladium-catalyzed
one-pot
synthesis
of
functionalized
furans
from
1,3-Dicarbonyl
compounds
and
alkenyl
bromides,
focusing
on
various
catalysts
reaction
parameters.
Different
catalysts,
including
PdCl₂(CH₃CN)₂,
Pd(OAc)₂,
Pd(acac)2
as
well
solvents,
bases,
oxidants,
were
systematically
evaluated.
PdCl₂(CH₃CN)₂
emerged
most
effective
catalyst,
achieving
a
remarkable
yield
94%.
Optimal
conditions
identified
in
dioxane
at
80
°C
with
K₂CO₃
base
CuCl₂
oxidant.
also
explored
1,3-diketones
Cyclohexane-1,3-dione,
5,5-Dimethylcyclohexane-1,3-dione,
2H-Pyran-3,5(4H,6H)-dione,
Cyclopentane-1,3-dione,
Pentane-2,4-dione,
Ethyl
3-oxobutanoate,
1,3-Diphenylpropane-1,3-dione,
1,3-Dip-tolylpropane-1,3-dione,
1,3-Bis(4-chlorophenyl)propane-1,3-dione,
1,3-Bis(4-bromo-
phenyl)propane-1,3-dione,
alongside
different
bromides
such
allyl
bromide,
(E)-1-Bromo-3,4-dimethylpent-2-ene,
1-Bromo-3-methylbut-2-ene,
3-Bromocyclohex-1-ene,
(E)-1-Bromohex-2-ene.
These
variations
demonstrated
method’s
versatility
significant
impact
substituents
reactivity
yield.
findings
highlight
importance
optimizing
to
maximize
efficiency
provide
insights
into
improving
catalytic
processes
for
enhanced
product
yields.
Язык: Английский
Construction of Quaternary Alkyl Motifs through Palladium- Catalyzed Oxidative Coupling of 1,3-Dicarbonyl Compounds with Alkenes Followed by C-C Bond Cleavage
Xu Zhang,
Mengfan Chang,
Tongtong Ni
и другие.
Chemical Communications,
Год журнала:
2024,
Номер
60(78), С. 10958 - 10961
Опубликована: Янв. 1, 2024
A
palladium-catalyzed
coupling
reaction
has
been
developed
for
the
generation
of
tertiary
alkylation
products
by
reacting
olefins
with
diversely
functionalized
1,3-dicarbonyls.
The
involves
C-H
1,3-dicarbonyls
to
produce
a
alcohol,
followed
C-C
bond
cleavage.
Язык: Английский
Rhodaelectro-Catalyzed Synthesis of Pyrano[3,4-b]indol-1(9H)-ones via the Double Dehydrogenative Heck Reaction between Indole-2-carboxylic Acids and Alkenes
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
A
rhodaelectro-catalyzed
double
dehydrogenative
Heck
reaction
of
indole-2-carboxylic
acids
with
alkenes
has
been
developed
for
the
synthesis
pyrano[3,4-
Язык: Английский