Targets,
Год журнала:
2024,
Номер
2(4), С. 372 - 384
Опубликована: Ноя. 19, 2024
Molecular
cages
have
promising
host–guest
properties
for
drug
delivery
applications.
Specifically,
guest⊂cage
complexes
can
be
used
the
on-command
release
of
encapsulated
guest
molecules
in
response
to
specific
stimuli.
This
research
explores
both
dynamic
and
constrictive
binding
systems
encapsulation
biological
environments.
In
systems,
rapidly
passes
in-and-out
through
portals
cage,
enabling
vitro
but
facing
limitations
vivo
due
dilution
effects
that
result
release.
These
challenges
are
addressed
by
where
is
trapped
a
“gate-closed”
state
within
cage.
these
triggered
“gate
opening”
event,
which
lowers
guest–out
energy
barrier.
A
full
achieved
when
gate
opening
reduces
cage–guest
affinity,
making
more
effective
controlled
delivery.
As
result,
this
study
shows
suitable
contexts.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 2, 2025
The
development
of
new
chiral
building
blocks
for
constructing
complex
architectures,
such
as
macrocycles
and
cages,
is
both
crucial
challenging.
Although
concave-shaped
calixarenes
have
been
established
versatile
the
synthesis
cage
compounds,
there
are
no
reports
on
cages
constructed
from
calix[4]arene
derivatives.
Herein,
we
present
a
straightforward
effective
method
gram-scale
member
macrocycle
enantiomers,
namely,
phenol[4]arene
(PC[4]A).
As
proof
concept,
functionalized
these
enantiomers
into
tetraformylphenol[4]arene
(PC[4]ACHO)
derivatives
via
Duff
reaction
to
construct
porous
organic
(CPOCs)
using
polyamine
synthons.
Specifically,
employ
two
fluorescent
amine
synthons,
bis(4-aminophenyl)phenylamine
tris(4-aminophenyl)amine,
assemble
with
PC[4]ACHO
resulting
in
[2
+
4]
lantern-shaped
[6
8]
truncated
octahedral
CPOCs,
respectively.
These
structures
unambiguously
characterized
by
single-crystal
X-ray
diffraction
circular
dichroism
(CD)
spectroscopy.
Notably,
CPOCs
exhibit
internal
diameters
approximately
3.1
nm,
cavity
volume
around
5300
Å3,
high
specific
surface
areas
up
1300
m2
g-1
after
desolvation,
making
them
among
largest
reported.
Additionally,
investigations
their
sensing
performance
demonstrate
that
PC[4]A-based
enable
enantioselective
recognition
amino
acids
This
work
strongly
suggests
PC[4]A
can
serve
an
excellent
block
rational
design
materials
practical
applications.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(21), С. 10380 - 10408
Опубликована: Янв. 1, 2024
Stemming
from
early
seminal
notions
of
molecular
recognition
and
encapsulation,
three-dimensional,
cavity-containing
capsular
compounds
assemblies
have
attracted
intense
interest
due
to
the
ability
modulate
chemical
physical
properties
species
encapsulated
within
these
confined
spaces
compared
bulk
environments.
With
such
a
diverse
range
covalent
motifs
non-covalent
(supramolecular)
interactions
available
assemble
building
blocks,
an
incredibly
wide-range
capsular-type
architectures
been
developed.
Furthermore,
synthetic
tunability
internal
environments
gives
chemists
opportunity
engineer
systems
for
uses
in
sensing,
sequestration,
catalysis
transport
molecules,
just
name
few.
In
this
tutorial
review,
overview
is
provided
into
design
principles,
synthesis,
characterisation,
structural
facets
coordination
cages,
porous
organic
supramolecular
capsules,
foldamers
mechanically
interlocked
molecules.
Using
recent
examples,
advantages
limitations
each
system
are
explored,
highlighting
their
application
various
tasks
functions.
Results in Chemistry,
Год журнала:
2024,
Номер
8, С. 101588 - 101588
Опубликована: Июнь 1, 2024
Polyaromatic
hydrocarbons
(PAHs)
pose
a
significant
threat
to
ecosystems
and
human
health
due
their
widespread
presence
persistence
in
the
environment.
Conventional
remediation
techniques
often
fall
short
both
efficiency
environmental
impact.
However,
recent
advancements
utilizing
organic
macrocyclic
host
molecules
show
considerable
promise
for
effectively
sequestering
eliminating
PAHs
across
diverse
media.
These
play
central
role
host–guest
chemistry
supramolecular
chemistry.
It
offers
distinct
advantages
by
virtue
of
precisely
tailored
cavities
customizable
functionalities,
greatly
enhancing
selective
recognition
abilities
towards
guest
PAHs.
The
pursuit
designing
synthesizing
novel
functional
macrocycles
has
captivated
attention
researchers,
driven
quest
address
various
challenges
research.
Over
decades
dedicated
exploration
chemistry,
an
expansive
array
molecules,
constructed
from
building
blocks,
have
emerged
as
pivotal
tools
encapsulating
This
review
presents
overview
progress
design,
synthesis,
application
purely
encapsulation
elucidates
underlying
principles
that
govern
ability
recognise
PAHs,
such
interactions,
shape
complementarity,
π-π
stacking
interactions.
Furthermore,
discusses
experimental
methodologies,
spectroscopic
analyses,
chromatography,
computational
modelling,
employed
assess
cage
PAH
trapping.
Additionally,
considerations
regarding
scalability
implications
cage-based
trapping
systems
are
addressed.
insights
gleaned
this
research
provide
valuable
guidance
development
robust
strategies
combat
pollution
contexts.
Crystal Growth & Design,
Год журнала:
2024,
Номер
24(14), С. 6081 - 6094
Опубликована: Июль 1, 2024
Due
to
their
unique
structural
characteristics,
molecular
cages
have
become
pivotal
components
in
supramolecular
chemistry
and
materials
science.
These
possess
the
remarkable
ability
encapsulate
guest
molecules
metal
nanoparticles
within
cavities,
fostering
intriguing
host–guest
interactions
demonstrating
significant
potential
across
various
domains,
including
recognition,
drug
delivery,
catalysis,
material
synthesis.
Integrating
these
with
highly
porous
crystalline
covalent
organic
frameworks
(COFs)
constitutes
a
strategic
avenue
for
enhancing
both
porosity
functional
sites.
This
transition
from
COF
involves
precise
orchestration
of
individual
into
extended,
covalently
bonded
structures
well-defined
porosity.
unlocks
novel
pathways
design
applications,
significantly
enriching
landscape
review
comprehensively
summarizes
synthetic
strategies
employed
fabricating
cage-based
COFs,
explores
diverse
provides
insights
future
prospects
growth
this
rapidly
evolving
field.
Analytical Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
novel
amide-based
molecular
cage
was
utilized
for
the
highly
selective
and
sensitive
fluorescence
based
detection
of
nicotine
in
human
urine
cigarette
samples.
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Porous
zirconium-based
coordination
cages
are
promising
materials
for
applications
in
gas
adsorption,
catalysis,
and
molecular
separation
due
to
their
tunability
stability.
However,
synthesis
is
often
complicated
by
the
formation
of
competing
phases,
including
insoluble
or
poorly
soluble
byproducts
that
impact
purity
composition.
Moreover,
product
composition
solubility
can
vary
widely
factors
such
as
humidity,
seasonal
fluctuations,
lab-to-lab
variations,
highlighting
inherent
lack
robustness
these
syntheses.
In
this
work,
we
investigate
how
solvothermal
conditions,
particularly
temperature
solvent
decomposition,
influence
cages.
We
show
elevated
temperatures
accelerate
breakdown,
leading
incorporation
formate
acetate
alter
final
cage
structures
contribute
zirconium-based,
amorphous
solids.
By
systematically
varying
reaction
optimized
isolated
products,
achieving
improved
phase
purity.
optimizing
synthetic
parameters,
achieve
control
over
particle
morphology
while
mitigating
effects
decomposition.
Our
findings
provide
insights
into
balance
between
ligand
effects,
enabling
development
strategies
enhance
purity,
porosity,
functionality
Chemical Communications,
Год журнала:
2024,
Номер
60(47), С. 6023 - 6026
Опубликована: Янв. 1, 2024
Inexpensive
calculations
and
high-throughput
crystallisations
were
used
to
identify
accessible
cage
conformations
by
‘locking’
them
in
the
solid
state.
The
conformers
suggest
adaptability
towards
binding
a
wide
array
of
target
guest
molecules.
