Accessing 3,4-Dihydroquinolinone from N-Arylacrylamides via Tetralone-Mediated Energy Transfer and 1,3-Hydrogen Shift
Organic Letters,
Год журнала:
2024,
Номер
26(12), С. 2398 - 2402
Опубликована: Март 18, 2024
Herein,
we
introduce
a
tetralone-mediated
photocyclization
method
of
N-arylacrylamides.
The
protocol
proceeds
smoothly
to
deliver
diverse
set
3,4-dihydroquinolinones
in
moderate
good
yields
with
excellent
functional
group
compatibility
and
readily
allows
for
late-stage
modifications
number
complex
drug
molecules.
Mechanistic
studies
reveal
that
the
present
systems
ultraviolet
light
irradiation
enable
cyclization
via
energy
transfer
exclusive
1,3-hydrogen
shift.
Язык: Английский
HFIP-promoted synthesis of imidazo [1,2-a]pyridines containing CF3-substituted tertiary alcohols at room temperature
Tetrahedron,
Год журнала:
2024,
Номер
156, С. 133943 - 133943
Опубликована: Март 19, 2024
Язык: Английский
Accessing pyrrolo[1,2-a]indole derivatives via visible-light-induced dearomatizative cyclization of indoles
Chemical Communications,
Год журнала:
2024,
Номер
60(37), С. 4902 - 4905
Опубликована: Янв. 1, 2024
Dearomatizative
cyclization
of
indoles:
a
novel
synthetic
method
for
pyrrolo[1,2-
]indole
derivatives
through
visible-light-induced
cascade
dearomatizative
indoles
with
external
nucleophiles
has
been
developed.
Язык: Английский
Formation of cyclopenta[c]quinolines through visible-light-induced photoredox cascade bis-annulations of 1,7-enynes with sulfoxonium ylides
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(37), С. 7618 - 7622
Опубликована: Янв. 1, 2024
A
novel
visible-light-driven
photoredox-catalyzed
cascade
bicyclization
of
1,7-enynes
with
aqueous
sulfoxonium
ylides
is
reported.
The
reaction
highly
chemoselective
three
new
C-C
bonds,
two
rings,
and
an
all-carbon
quaternary
stereocenter
constructed
in
a
one-pot
fashion.
This
mild
protocol
features
remarkably
broad
substrate
scope
good
functional
group
tolerance,
providing
general
practical
approach
to
access
various
cyclopenta[
Язык: Английский
Synthesis of Oxazoles Containing CF3-Substituted Alcohol Unit via Tandem Cycloisomerization/Hydroxyalkylation from N-Propargylamides with Trifluoropyruvates
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5848 - 5848
Опубликована: Дек. 11, 2024
Oxazoles
are
important
five-membered
heterocycles
that
contain
both
nitrogen
and
oxygen
atoms.
Due
to
their
wide
range
of
biological
activities,
many
oxazoles
demonstrate
potential
for
extensive
application
in
various
fields,
including
medicinal
chemistry.
Trifluoromethyl
carbinol,
an
pharmacophore,
contains
trifluoromethyl
hydroxyl
groups
is
common
molecules
with
activities.
Constructing
a
carbinol
unit
undoubtedly
valuable
expanding
the
chemical
space
drug
discovery.
In
this
study,
simple
efficient
method
was
developed
synthesis
containing
CF3-substituted
alcohol
via
tandem
cycloisomerization/hydroxyalkylation
N-propargylamides
trifluoropyruvates
through
rational
Lewis
acid
catalytic
mechanism.
This
Zn(OTf)2-catalyzed
synthetic
protocol
operationally
provides
series
moderate
good
yields.
The
demonstrates
broad
substrate
scope,
high
functional
group
tolerance,
atom
economy
can
achieve
gram-level
reactions,
indicating
strong
possibility
its
practical
application.
Язык: Английский
Hfip-Promoted Synthesis Of Imidazo[1,2-A]Pyridines Containing Cf3-Substituted Tertiary Alcohols At Room Temperature
Опубликована: Янв. 1, 2024
Download
This
Paper
Open
PDF
in
Browser
Add
to
My
Library
Share:
Permalink
Using
these
links
will
ensure
access
this
page
indefinitely
Copy
URL
DOI
Язык: Английский
Synthesis of 2,4-Dicyanoalkylated Benzoxazines through the Radical-Mediated Cascade Cyclization of Isocyanides with AIBN under Metal- and Additive-Free Conditions
Mengjia Ni,
Shuanggen Gui,
Yang Fu
и другие.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(6), С. 3970 - 3976
Опубликована: Фев. 29, 2024
A
general
and
novel
method
for
the
radical
cascade
cyclization
of
aryl
isocyanides
with
AIBN
has
been
described.
This
strategy
provides
straightforward
access
to
various
2,4-dicyanoalkylated
benzoxazines
in
moderate
good
yields
under
metal-
additive-free
conditions.
The
reaction
can
apply
a
gram
scale
tolerate
diverse
functional
groups.
2,4-Dicyanoalkylated
benzoxazine
derivatives
feature
large
Stokes
shift
intramolecular
charge
transfer
properties.
Язык: Английский
Photoredox Radical Truce–Smiles Rearrangement of N-Sulfinyl Acrylamides with Bromodifluoroacetamides
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
We
herein
report
a
photochemical
Truce–Smiles
rearrangement
reaction
of
N-sulfinyl
acrylamides
with
bromodifluoroacetamides
resulting
in
the
synthesis
series
aryl
difluoroglutaramides
moderate
to
good
yields.
The
asymmetric
using
chiral
sulfinamides
produced
quaternary
carbon-centered
glutaramide
products
modest
enantioselectivity.
This
protocol
effectively
complements
previous
methods
involving
N-sulfonyl
acrylamides.
Язык: Английский