Oxo-Sulfonylation of 1,7-Enynes via a Multicomponent Oxidative Radical Polar Crossover Approach
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Diastereoselective
synthesis
of
trans-3,4-difunctionalized
tetrahydroquinoline
and
chromane
derivatives
via
the
oxo-sulfonylation
1,7-enynes
is
demonstrated.
The
reaction
involves
a
three-component
oxidative
radical
polar
crossover
(ORPC)
approach
wherein
vinyl
carbocation
intermediate
undergoes
nucleophilic
substitution
to
afford
corresponding
keto
functional
group.
Deprotection
N-Ts
group,
gram-scale
synthesis,
other
synthetic
applications
were
illustrated.
Control
experiments
mechanistic
studies
show
that
water
acts
as
nucleophile
in
this
reaction.
Язык: Английский
Visible-Light-Induced photoredox aerobic coupling of sulfonium ylides and amines leading to E-selective formation of 2-amino-2-butene-1,4-diones
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
novel
visible-light-induced
photoredox
three-component
aerobic
coupling
reaction
of
sulfoxonium
ylides
and
amines
is
reported.
Язык: Английский