Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
photochemical
radical
cascade
cyclization
reaction
of
isocyanides
with
α-carbonyl
bromides
under
mild
conditions
is
disclosed
for
accessing
1,4-dibenzodiazepines,
demonstrating
good
tolerance
towards
various
functional
groups.
Язык: Английский
Visible Light‐Induced Radical Tandem Cyclization of o‐Isocyanodiaryl Amines with Arylthiodifluoroalkyl 2‐Pyridyl Sulfones or Difluormethyl‐ Bromides
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(41)
Опубликована: Авг. 6, 2024
Abstract
A
visible‐light‐induced
photoredox‐catalyzed
radical
tandem
cyclization
of
o
‐isocyanodiaryl
amines
with
arylthiodifluoroalkyl
2‐pyridyl
sulfones
or
difluormethyl
bromides
has
been
realized
for
the
first
time.
The
reaction
works
a
broad
range
substrates
and
provides
simple
efficient
method
synthesis
11‐difluoromethyl‐substituted
dibenzodiazepines
from
easily
available
starting
materials
in
very
mild
conditions.
Язык: Английский