Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines
Ao-Long Li,
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R.-Q. Xie,
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Quan Zhou
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et al.
Organic & Biomolecular Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
photochemical
radical
cascade
cyclization
reaction
of
isocyanides
with
α-carbonyl
bromides
under
mild
conditions
is
disclosed
for
accessing
1,4-dibenzodiazepines,
demonstrating
good
tolerance
towards
various
functional
groups.
Language: Английский
Visible Light‐Induced Radical Tandem Cyclization of o‐Isocyanodiaryl Amines with Arylthiodifluoroalkyl 2‐Pyridyl Sulfones or Difluormethyl‐ Bromides
Yong‐Xin Liang,
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Qing-Wen Ai,
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Zixuan Yang
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et al.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(41)
Published: Aug. 6, 2024
Abstract
A
visible‐light‐induced
photoredox‐catalyzed
radical
tandem
cyclization
of
o
‐isocyanodiaryl
amines
with
arylthiodifluoroalkyl
2‐pyridyl
sulfones
or
difluormethyl
bromides
has
been
realized
for
the
first
time.
The
reaction
works
a
broad
range
substrates
and
provides
simple
efficient
method
synthesis
11‐difluoromethyl‐substituted
dibenzodiazepines
from
easily
available
starting
materials
in
very
mild
conditions.
Language: Английский