Cambridge Quarterly of Healthcare Ethics,
Год журнала:
2024,
Номер
unknown, С. 1 - 22
Опубликована: Дек. 4, 2024
Abstract
Brain–computer
interfaces
(BCIs)
exemplify
a
dual-use
neurotechnology
with
significant
potential
in
both
civilian
and
military
contexts.
While
BCIs
hold
promise
for
treating
neurological
conditions
such
as
spinal
cord
injuries
amyotrophic
lateral
sclerosis
the
future,
decisionmakers
countries
United
States
China
also
see
their
to
enhance
combat
capabilities.
Some
predict
that
U.S.
Special
Operations
Forces
(SOF)
will
be
early
adopters
of
BCI
enhancements.
This
article
argues
shift
focus:
Command
(SOCOM)
should
pursue
translational
research
medical
severely
injured
or
ill
SOF
personnel.
After
two
decades
continuous
engagement
on-going
high-risk
operations,
personnel
face
unique
injury
patterns,
physical
psychological,
which
technology
could
help
address.
The
identifies
six
key
applications
benefit
wounded
members
discusses
ethical
implications
involving
related
these
applications.
Ultimately,
challenges
traditional
civilian-military
divide
neurotechnology,
arguing
by
collaborating
more
closely
stakeholders,
scientists
can
not
only
individuals
needs,
including
servicemembers,
but
play
role
shaping
future
technology.
International Journal of Science and Research Archive,
Год журнала:
2024,
Номер
11(1), С. 702 - 717
Опубликована: Янв. 30, 2024
This
study
provides
a
comprehensive
analysis
of
the
developments,
ethical
considerations,
and
future
prospects
brain-computer
interfaces
(BCIs)
in
United
States.
The
primary
objective
was
to
explore
historical
evolution,
current
advancements,
potential
societal
impacts
neural
human-computer
interaction.
Employing
systematic
literature
review
content
methodology,
analyzed
peer-reviewed
articles,
government
reports,
industry
analyses
published
between
2015
2023.
Key
findings
reveal
significant
technological
advancements
interfaces,
highlighting
their
transformative
various
sectors.
However,
these
are
accompanied
by
complex
dilemmas,
particularly
concerning
privacy,
security,
equitable
access.
underscores
necessity
balancing
innovation
with
considerations
landscape
interfaces.
Strategic
recommendations
for
stakeholders
include
fostering
collaborative
efforts
across
academia,
industry,
government,
developing
robust
regulatory
frameworks,
prioritizing
responsible
research
development.
conclusion
emphasizes
importance
foresight
engagement
navigating
road
ahead
U.S.
contributes
understanding
providing
insights
into
benefits
challenges,
offers
framework
sustainable
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The
blood-brain
barrier
(BBB)
is
a
crucial
structure
that
maintains
brain
homeostasis
by
regulating
the
entry
of
molecules
and
cells
from
bloodstream
into
central
nervous
system
(CNS).
Neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's
disease,
well
ischemic
stroke,
compromise
integrity
BBB.
This
leads
to
increased
permeability
infiltration
harmful
substances,
thereby
accelerating
neurodegeneration.
In
this
review,
we
explore
mechanisms
underlying
BBB
disruption,
including
oxidative
stress,
neuroinflammation,
vascular
dysfunction,
loss
tight
junction
integrity,
in
patients
with
neurodegenerative
diseases.
We
discuss
how
breakdown
contributes
neurotoxicity,
abnormal
accumulation
pathological
proteins,
all
which
exacerbate
neuronal
damage
facilitate
disease
progression.
Furthermore,
potential
therapeutic
strategies
aimed
at
preserving
or
restoring
function,
anti-inflammatory
treatments,
antioxidant
therapies,
approaches
enhance
integrity.
Given
role
neurodegeneration,
maintaining
its
represents
promising
approach
slow
prevent
progression
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 21, 2025
Neural
interface
technologies
are
increasingly
evolving
towards
bio-inspired
approaches
to
enhance
integration
and
long-term
functionality.
Recent
strategies
merge
soft
materials
with
tissue
engineering
realize
biologically-active
and/or
cell-containing
living
layers
at
the
tissue-device
that
enable
seamless
biointegration
novel
cell-mediated
therapeutic
opportunities.
This
review
maps
field
of
electronics
discusses
key
recent
developments
in
tissue-like
regenerative
bioelectronics,
from
biomaterials
surface-functionalized
bioactive
coatings
'biohybrid'
'all-living'
interfaces.
We
define
contextualize
terminology
this
emerging
highlight
how
biological
components
can
bridge
gap
clinical
translation.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
13(10), С. 3390 - 3404
Опубликована: Янв. 1, 2025
Although
neural
tissue
engineering
holds
great
therapeutic
potential
for
multiple
clinical
applications,
one
important
challenge
is
the
development
of
scaffolds
that
provide
cues
required
development.
To
achieve
this,
biomaterial
systems
can
be
leveraged
to
present
appropriate
biological,
mechanical,
topographical
and
electrical
could
direct
cell
fate.
In
this
study,
a
multi-layered
electrode
construct
was
engineered
used
as
platform
3D
encapsulation
in
vitro
applications.
The
first
layer
conductive
hydrogel
coating,
improves
conductivity
from
underlying
platinum
electrode.
second
biosynthetic
hydrogel,
specifically
tailored
support
This
layered
electrochemically
characterised,
numerical
model
applied
study
stimuli
reaching
layer.
shown
effectively
growth
proliferation
encapsulated
astrocytes
within
layer,
while
will
enable
computational
experimentation
benchmarking
validation.
highly
versatile
system
represents
robust
tool
influence
on
fate,
well
investigating
biohybrid
interfaces
vitro.
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 11, 2025
Neuromorphic
computing
technologies
are
about
to
change
modern
computing,
yet
most
work
thus
far
has
emphasized
hardware
development.
This
review
focuses
on
the
latest
progress
in
algorithmic
advances
specifically
for
potential
use
brain
implants.
We
discuss
current
algorithms
and
emerging
neurocomputational
models
that,
when
implemented
neuromorphic
hardware,
could
match
or
surpass
traditional
methods
efficiency.
Our
aim
is
inspire
creation
deployment
of
that
not
only
enhance
computational
performance
implants
but
also
serve
broader
fields
like
medical
diagnostics
robotics
inspiring
next
generations
neural
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 3, 2024
Abstract
Restoring
functional
vision
in
blind
patients
lacking
a
healthy
optic
nerve
requires
bypassing
retinal
circuits,
ideally,
by
directly
stimulating
the
visual
thalamus.
However,
available
deep
brain
stimulation
electrodes
do
not
provide
resolution
required
for
restoration.
We
developed
an
implantable
biohybrid
model
designed
synaptic
of
targets.
The
interface
combines
stretchable
array
with
aligned
microfluidic
axon
guidance
system
seeded
neural
spheroids
to
facilitate
development
3
mm
long
nerve-like
structure.
A
bioresorbable
hydrogel
conduit
was
used
as
bridge
between
tissue
and
implant.
demonstrated
within
structure
vitro
high-density
CMOS
microelectrode
arrays
show
faithful
activity
conduction
across
device.
Finally,
implantation
onto
mouse
cortex
showed
that
grow
axons
vivo
remain
functionally
active
more
than
22
days
post-implantation.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(10), С. 11910 - 11920
Опубликована: Май 14, 2024
Neural
electrodes
are
the
core
components
of
neural
interfaces,
which
widely
used
in
diagnosis
and
treatment
neurological
disorders
by
accurately
detecting
regulating
bioelectric
activity.
However,
traditional
face
challenges
such
as
low
acquisition
sensitivity
poor
biocompatibility
due
to
limited
charge
injection
capability
mechanical
mismatch
at
tissue–electrode
interface.
Herein,
we
developed
two-dimensional
(2D)
quantum
material-modified
based
on
WSe2
WS2
dots
(QDs)
that
achieved
improvements
both
signal
recording
quality
biocompatibility.
Due
significantly
increased
effective
reaction
surface
area
faster
electronic
transfer,
impedance
CSCc
2D
optimized
have
improved
2.4-fold
4.0-fold,
respectively,
resulted
enhanced
vivo
detection
over
entire
frequency
range.
The
electrode
exhibits
excellent
long-term
stability,
with
a
maximum
88.6%,
ensuring
stability
structure
performance.
Excellent
antioxidant
CAT-like
activity
reduce
glial
scar
neuronal
death
improve
current
work
has
laid
foundation
for
application
materials
TMDs
MXenes
electrodes,
holding
great
promise
advancements
neuroscience
research
medical
applications.
