Sensors and Actuators Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100274 - 100274
Published: Dec. 1, 2024
Language: Английский
International Journal of Science and Research Archive, Journal Year: 2024, Volume and Issue: 11(1), P. 702 - 717
Published: Jan. 30, 2024
This study provides a comprehensive analysis of the developments, ethical considerations, and future prospects brain-computer interfaces (BCIs) in United States. The primary objective was to explore historical evolution, current advancements, potential societal impacts neural human-computer interaction. Employing systematic literature review content methodology, analyzed peer-reviewed articles, government reports, industry analyses published between 2015 2023. Key findings reveal significant technological advancements interfaces, highlighting their transformative various sectors. However, these are accompanied by complex dilemmas, particularly concerning privacy, security, equitable access. underscores necessity balancing innovation with considerations landscape interfaces. Strategic recommendations for stakeholders include fostering collaborative efforts across academia, industry, government, developing robust regulatory frameworks, prioritizing responsible research development. conclusion emphasizes importance foresight engagement navigating road ahead U.S. contributes understanding providing insights into benefits challenges, offers framework sustainable
Language: Английский
Citations
31
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 386 - 386
Published: Jan. 9, 2025
The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression
Language: Английский
Citations
5
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 21, 2025
Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering realize biologically-active and/or cell-containing living layers at the tissue-device that enable seamless biointegration novel cell-mediated therapeutic opportunities. This review maps field of electronics discusses key recent developments in tissue-like regenerative bioelectronics, from biomaterials surface-functionalized bioactive coatings 'biohybrid' 'all-living' interfaces. We define contextualize terminology this emerging highlight how biological components can bridge gap clinical translation.
Language: Английский
Citations
5
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: 13(10), P. 3390 - 3404
Published: Jan. 1, 2025
Although neural tissue engineering holds great therapeutic potential for multiple clinical applications, one important challenge is the development of scaffolds that provide cues required development. To achieve this, biomaterial systems can be leveraged to present appropriate biological, mechanical, topographical and electrical could direct cell fate. In this study, a multi-layered electrode construct was engineered used as platform 3D encapsulation in vitro applications. The first layer conductive hydrogel coating, improves conductivity from underlying platinum electrode. second biosynthetic hydrogel, specifically tailored support This layered electrochemically characterised, numerical model applied study stimuli reaching layer. shown effectively growth proliferation encapsulated astrocytes within layer, while will enable computational experimentation benchmarking validation. highly versatile system represents robust tool influence on fate, well investigating biohybrid interfaces vitro.
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: April 11, 2025
Neuromorphic computing technologies are about to change modern computing, yet most work thus far has emphasized hardware development. This review focuses on the latest progress in algorithmic advances specifically for potential use brain implants. We discuss current algorithms and emerging neurocomputational models that, when implemented neuromorphic hardware, could match or surpass traditional methods efficiency. Our aim is inspire creation deployment of that not only enhance computational performance implants but also serve broader fields like medical diagnostics robotics inspiring next generations neural
Language: Английский
Citations
0
Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 282, P. 117492 - 117492
Published: April 17, 2025
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 159, P. 114833 - 114833
Published: May 19, 2025
Language: Английский
Citations
0
Surface and Coatings Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132299 - 132299
Published: May 1, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 3, 2024
Abstract Restoring functional vision in blind patients lacking a healthy optic nerve requires bypassing retinal circuits, ideally, by directly stimulating the visual thalamus. However, available deep brain stimulation electrodes do not provide resolution required for restoration. We developed an implantable biohybrid model designed synaptic of targets. The interface combines stretchable array with aligned microfluidic axon guidance system seeded neural spheroids to facilitate development 3 mm long nerve-like structure. A bioresorbable hydrogel conduit was used as bridge between tissue and implant. demonstrated within structure vitro high-density CMOS microelectrode arrays show faithful activity conduction across device. Finally, implantation onto mouse cortex showed that grow axons vivo remain functionally active more than 22 days post-implantation.
Language: Английский
Citations
2
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(10), P. 11910 - 11920
Published: May 14, 2024
Neural electrodes are the core components of neural interfaces, which widely used in diagnosis and treatment neurological disorders by accurately detecting regulating bioelectric activity. However, traditional face challenges such as low acquisition sensitivity poor biocompatibility due to limited charge injection capability mechanical mismatch at tissue–electrode interface. Herein, we developed two-dimensional (2D) quantum material-modified based on WSe2 WS2 dots (QDs) that achieved improvements both signal recording quality biocompatibility. Due significantly increased effective reaction surface area faster electronic transfer, impedance CSCc 2D optimized have improved 2.4-fold 4.0-fold, respectively, resulted enhanced vivo detection over entire frequency range. The electrode exhibits excellent long-term stability, with a maximum 88.6%, ensuring stability structure performance. Excellent antioxidant CAT-like activity reduce glial scar neuronal death improve current work has laid foundation for application materials TMDs MXenes electrodes, holding great promise advancements neuroscience research medical applications.
Language: Английский
Citations
1