The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The
blood-brain
barrier
(BBB)
is
a
crucial
structure
that
maintains
brain
homeostasis
by
regulating
the
entry
of
molecules
and
cells
from
bloodstream
into
central
nervous
system
(CNS).
Neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's
disease,
well
ischemic
stroke,
compromise
integrity
BBB.
This
leads
to
increased
permeability
infiltration
harmful
substances,
thereby
accelerating
neurodegeneration.
In
this
review,
we
explore
mechanisms
underlying
BBB
disruption,
including
oxidative
stress,
neuroinflammation,
vascular
dysfunction,
loss
tight
junction
integrity,
in
patients
with
neurodegenerative
diseases.
We
discuss
how
breakdown
contributes
neurotoxicity,
abnormal
accumulation
pathological
proteins,
all
which
exacerbate
neuronal
damage
facilitate
disease
progression.
Furthermore,
potential
therapeutic
strategies
aimed
at
preserving
or
restoring
function,
anti-inflammatory
treatments,
antioxidant
therapies,
approaches
enhance
integrity.
Given
role
neurodegeneration,
maintaining
its
represents
promising
approach
slow
prevent
progression
Язык: Английский
Colorimetric Molecularly Imprinted Polymer-Based Sensors for Rapid Detection of Organic Compounds: A Review
Chemosensors,
Год журнала:
2025,
Номер
13(5), С. 163 - 163
Опубликована: Май 4, 2025
This
review
offers
a
comprehensive
examination
of
the
development
and
current
state
art
in
field
molecularly
imprinted
polymer
(MIP)-based
colorimetric
sensors,
focusing
on
their
potential
for
rapid
detection
organic
compounds.
These
MIP-sensors
are
gaining
considerable
attention
due
to
distinctive
capacity
modify
sensor
surfaces
by
creating
recognition
cavities
within
matrix,
providing
versatile
highly
selective
platform
detecting
broad
spectrum
analytes.
systematically
examines
different
types
MIP-based
attending
target
analyte,
highlighting
applications
on-site
sample
detection,
drug
monitoring,
environmental
analysis,
food
safety
detection.
The
integration
novel
technologies,
such
as
nanozymes
smartphone-based
which
enhance
capabilities
MIP
is
also
addressed.
sensors
particularly
valuable
low
cost,
response
times,
portability,
ease
use.
Finally,
outlines
future
challenges
overcoming
existing
limitations,
improving
performance,
expanding
across
various
fields.
Язык: Английский
Effects of taurine on the growth performance, diarrhea, oxidative stress and intestinal barrier function of weanling piglets
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 7, 2024
Oxidative
damage
resulting
from
weaning
stress
significantly
impacts
the
growth
performance
and
health
status
of
piglets.
Taurine,
a
dietary
antioxidant
with
diverse
functions,
was
investigated
in
this
study
for
its
protective
role
against
stress-induced
oxidative
underlying
mechanism.
Forty
28-day-old
male
castrated
weaned
piglets
were
randomly
assigned
to
four
groups.
The
control
group
received
basal
diet,
while
experimental
groups
fed
diet
supplemented
0.1,
0.2%,
or
0.3%
taurine
over
28-day
period.
Язык: Английский
Review: Nanozyme-based point-of-care testing for portable and on-site monitoring of food contaminants
Trends in Food Science & Technology,
Год журнала:
2025,
Номер
161, С. 105062 - 105062
Опубликована: Май 2, 2025
Язык: Английский
Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection
Digital Health,
Год журнала:
2025,
Номер
11
Опубликована: Май 1, 2025
Neurodegenerative
diseases,
including
Alzheimer's
and
Parkinson's,
are
characterized
by
progressive
neuronal
loss,
leading
to
cognitive
motor
impairments.
Early
diagnosis
remains
a
challenge
due
the
slow
progression
of
symptoms
limitations
current
diagnostic
methods.
Nanobiosensors,
leveraging
high
sensitivity
specificity
nanotechnology,
offer
promising,
noninvasive,
cost-effective
approach
for
detecting
disease
biomarkers
at
ultra-low
concentrations.
This
review
highlights
recent
advancements
in
nanobiosensor
technology,
integration
gold
nanoparticles,
quantum
dots,
carbon
nanotubes,
which
have
significantly
enhanced
biomarker
detection
precision.
Furthermore,
it
examines
advantages
nanobiosensors
over
traditional
techniques,
such
as
improved
sensitivity,
rapid
detection,
minimal
invasiveness.
The
potential
these
innovative
sensors
revolutionize
early
improve
patient
outcomes
is
discussed,
along
with
existing
challenges
clinical
translation,
stability,
reproducibility,
regulatory
considerations.
Addressing
will
be
crucial
integrating
into
routine
practice
advancing
personalized
medicine
neurodegenerative
disorders.
Язык: Английский
Theoretical insights into the binding of mono/di-ethyl phthalates to superoxide dismutase and associated structural changes impairing antioxidant activity: A coupled molecular docking and dynamics simulation approach
The Science of The Total Environment,
Год журнала:
2025,
Номер
983, С. 179667 - 179667
Опубликована: Май 19, 2025
Язык: Английский
Nanozymes in Biomedical Applications: Innovations Originated From Metal‐Organic Frameworks
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 25, 2024
Abstract
Nanozymes
exhibit
significant
potential
in
medical
theranostics,
environmental
protection,
energy
development,
and
biopharmaceuticals
due
to
their
exceptional
catalytic
performance.
Compared
with
natural
enzymes,
nanozymes
have
the
advantages
of
simple
preparation
purification,
convenient
production
low
cost.
Therefore,
it
is
very
important
prepare
quickly
efficiently,
which
not
only
helps
expand
application
scope,
but
also
can
further
exert
great
various
fields.
Metal‐organic
frameworks
(MOF)
materials
serve
as
versatile
substrates
for
constructing
nanozymes,
offering
unique
like
adjustable
structure,
high
specific
surface
area,
porous
channels.
MOF
coordination
nodes
constructed
from
metal
ions
or
clusters
properties
that
be
leveraged
tailor
nanozyme
characteristics
different
applications.
This
review
describes
analyzes
recent
methods
using
materials,
explores
prospects
biomedicine.
By
expounding
techniques
biomedical
applications
this
aims
inspire
researchers
develop
innovative
explore
new
directions.
Язык: Английский
Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
Open Medicine,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 1, 2024
Abstract
Objective
To
explore
the
role
of
oxidative
stress
on
glycogen
synthase
kinase-3
in
lymphocytes
diabetes
mellitus
(DM)
patients
complicated
with
cerebral
infarction
(CI).
Materials
and
methods
A
total
186
DM
were
enrolled
according
to
inclusion
criteria
exclusion
criteria,
including
89
alone
(DM
group)
97
CI
+
CI)
group.
Eighty-one
selected
as
group,
80
normal
subjects
over
50
years
control
Superoxide
dismutase
(SOD)
activity,
glutathione
peroxidase
(GSH-Px)
malondialdehyde
(MDA)
content
serum
determined
by
colorimetric
assays.
Phosphorylation
GSK-3β
was
measured
enzyme-linked
immunosorbent
assay.
Results
(1)
Compared
SOD
GSH-Px
activities
group
decreased,
accompanied
higher
MDA
content.
Furthermore,
phosphorylation
decreased.
(2)
In
activity
decreased
days
7
10
month
3
compared
day
increased
from
0
On
1,
7,
10,
lower
than
3,
it
1
Conclusion
present
study,
we
demonstrated
that
peripheral
stronger,
GSK-3
higher.
It
suggested
might
enhance
which
provide
a
diagnostic
therapeutic
approach
for
CI,
targeting
is
promising
target
treatment
type
2
its
complications.
Язык: Английский
Luminescent Nanozyme-Based Sensors for Bacteria Detection
Applied Biochemistry and Microbiology,
Год журнала:
2024,
Номер
60(6), С. 1022 - 1034
Опубликована: Дек. 1, 2024
Язык: Английский
Expression, Purification, and Anti-UV Irradiation Effect of RsSOD on HCE-T Human Corneal Epithelial Cells
Genes,
Год журнала:
2024,
Номер
15(9), С. 1147 - 1147
Опубликована: Авг. 30, 2024
Superoxide
dismutase
(SOD)
is
a
class
of
enzymes
that
catalyze
the
disproportionation
superoxide
anion
radicals
into
hydrogen
peroxide
and
oxygen.
It
can
remove
excessive
free
in
organisms
acts
as
potent
antioxidant,
cleaning
generated
by
radiation
protecting
cells
from
oxidative
damage.
In
this
study,
we
obtained
MnSOD
gene
radiation-resistant
bacterium
Язык: Английский