Applied Biochemistry and Microbiology, Год журнала: 2024, Номер 60(6), С. 1022 - 1034
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression
Язык: Английский
Процитировано
5
Chemosensors, Год журнала: 2025, Номер 13(5), С. 163 - 163
Опубликована: Май 4, 2025
This review offers a comprehensive examination of the development and current state art in field molecularly imprinted polymer (MIP)-based colorimetric sensors, focusing on their potential for rapid detection organic compounds. These MIP-sensors are gaining considerable attention due to distinctive capacity modify sensor surfaces by creating recognition cavities within matrix, providing versatile highly selective platform detecting broad spectrum analytes. systematically examines different types MIP-based attending target analyte, highlighting applications on-site sample detection, drug monitoring, environmental analysis, food safety detection. The integration novel technologies, such as nanozymes smartphone-based which enhance capabilities MIP is also addressed. sensors particularly valuable low cost, response times, portability, ease use. Finally, outlines future challenges overcoming existing limitations, improving performance, expanding across various fields.
Язык: Английский
Процитировано
1
Frontiers in Veterinary Science, Год журнала: 2024, Номер 11
Опубликована: Авг. 7, 2024
Oxidative damage resulting from weaning stress significantly impacts the growth performance and health status of piglets. Taurine, a dietary antioxidant with diverse functions, was investigated in this study for its protective role against stress-induced oxidative underlying mechanism. Forty 28-day-old male castrated weaned piglets were randomly assigned to four groups. The control group received basal diet, while experimental groups fed diet supplemented 0.1, 0.2%, or 0.3% taurine over 28-day period.
Язык: Английский
Процитировано
5
Digital Health, Год журнала: 2025, Номер 11
Опубликована: Май 1, 2025
Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive motor impairments. Early diagnosis remains a challenge due the slow progression of symptoms limitations current diagnostic methods. Nanobiosensors, leveraging high sensitivity specificity nanotechnology, offer promising, noninvasive, cost-effective approach for detecting disease biomarkers at ultra-low concentrations. This review highlights recent advancements in nanobiosensor technology, integration gold nanoparticles, quantum dots, carbon nanotubes, which have significantly enhanced biomarker detection precision. Furthermore, it examines advantages nanobiosensors over traditional techniques, such as improved sensitivity, rapid detection, minimal invasiveness. The potential these innovative sensors revolutionize early improve patient outcomes is discussed, along with existing challenges clinical translation, stability, reproducibility, regulatory considerations. Addressing will be crucial integrating into routine practice advancing personalized medicine neurodegenerative disorders.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 25, 2024
Abstract Nanozymes exhibit significant potential in medical theranostics, environmental protection, energy development, and biopharmaceuticals due to their exceptional catalytic performance. Compared with natural enzymes, nanozymes have the advantages of simple preparation purification, convenient production low cost. Therefore, it is very important prepare quickly efficiently, which not only helps expand application scope, but also can further exert great various fields. Metal‐organic frameworks (MOF) materials serve as versatile substrates for constructing nanozymes, offering unique like adjustable structure, high specific surface area, porous channels. MOF coordination nodes constructed from metal ions or clusters properties that be leveraged tailor nanozyme characteristics different applications. This review describes analyzes recent methods using materials, explores prospects biomedicine. By expounding techniques biomedical applications this aims inspire researchers develop innovative explore new directions.
Язык: Английский
Процитировано
3
Trends in Food Science & Technology, Год журнала: 2025, Номер 161, С. 105062 - 105062
Опубликована: Май 2, 2025
Язык: Английский
Процитировано
0
The Science of The Total Environment, Год журнала: 2025, Номер 983, С. 179667 - 179667
Опубликована: Май 19, 2025
Язык: Английский
Процитировано
0
Genes, Год журнала: 2024, Номер 15(9), С. 1147 - 1147
Опубликована: Авг. 30, 2024
Superoxide dismutase (SOD) is a class of enzymes that catalyze the disproportionation superoxide anion radicals into hydrogen peroxide and oxygen. It can remove excessive free in organisms acts as potent antioxidant, cleaning generated by radiation protecting cells from oxidative damage. In this study, we obtained MnSOD gene radiation-resistant bacterium
Язык: Английский
Процитировано
0
Open Medicine, Год журнала: 2024, Номер 19(1)
Опубликована: Янв. 1, 2024
Abstract Objective To explore the role of oxidative stress on glycogen synthase kinase-3 in lymphocytes diabetes mellitus (DM) patients complicated with cerebral infarction (CI). Materials and methods A total 186 DM were enrolled according to inclusion criteria exclusion criteria, including 89 alone (DM group) 97 CI + CI) group. Eighty-one selected as group, 80 normal subjects over 50 years control Superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) malondialdehyde (MDA) content serum determined by colorimetric assays. Phosphorylation GSK-3β was measured enzyme-linked immunosorbent assay. Results (1) Compared SOD GSH-Px activities group decreased, accompanied higher MDA content. Furthermore, phosphorylation decreased. (2) In activity decreased days 7 10 month 3 compared day increased from 0 On 1, 7, 10, lower than 3, it 1 Conclusion present study, we demonstrated that peripheral stronger, GSK-3 higher. It suggested might enhance which provide a diagnostic therapeutic approach for CI, targeting is promising target treatment type 2 its complications.
Язык: Английский
Процитировано
0
Applied Biochemistry and Microbiology, Год журнала: 2024, Номер 60(6), С. 1022 - 1034
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0