A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Язык: Английский

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Piezoelectric catalytic driven advanced oxidation process using two-dimensional metal dichalcogenides for wastewater pollutants remediation

Chemosphere, Год журнала: 2024, Номер 353, С. 141524 - 141524

Опубликована: Фев. 23, 2024

Язык: Английский

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Piezoelectric Persulfate Activation Process for Oxidative Degradation of Aqueous Pollutants

Korean Journal of Chemical Engineering, Год журнала: 2024, Номер 41(7), С. 1871 - 1900

Опубликована: Март 19, 2024

Язык: Английский

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Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1⁺ Macrophages for Infectious Bone Defect Regeneration

ACS Nano, Год журнала: 2024, Номер 18(52), С. 35575 - 35594

Опубликована: Дек. 18, 2024

Infectious bone defects pose significant clinical challenges due to persistent infection and impaired healing. Icam1+ macrophages were identified as crucial previously unrecognized regulators in the repair of defects, where oxidative phosphorylation within this macrophage subset represents a barrier effective regeneration. To address challenge, dual-responsive iron-doped barium titanate (BFTO) nanoparticles synthesized with magnetic ultrasonic properties. These further loaded anti-inflammatory agent curcumin coated engineered mesenchymal stem cell membranes (EMM) modified γ3 peptide, creating BFTO-Cur@EMM specifically designed target macrophages. shown disrupt bacterial biofilms under alternating fields (AMF) activate osteogenic immune responses via low-intensity pulsed ultrasound (LIPUS). Transcriptomic sequencing validation experiments demonstrated that approach activates (OXPHOS) by stimulating JAK2-STAT3 pathway inhibiting MAPK-JNK pathway, thereby promoting polarization toward pro-reparative phenotype enhancing secretion pro-angiogenic cytokines. subsequently integrated into quaternized chitosan (QCS) tricalcium phosphate (TCP) create bioink for three-dimensional (3D) printing anti-infection QT/BFTO-Cur@EMM scaffolds. In vivo studies indicated these scaffolds significantly improved healing infectious without causing thermal damage surrounding tissues. This work highlights potential material targeting an strategy simultaneously controlling

Язык: Английский

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First-principles study on the stability, electronic structure, and band alignment of AgNbO3 surfaces: Understanding the adsorption process of H2O and O2

Computational Materials Science, Год журнала: 2024, Номер 246, С. 113398 - 113398

Опубликована: Сен. 20, 2024

Язык: Английский

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Enhanced piezocatalytic activity induced by triboelectric effect and Schottky junction at interface of ABiTiO (A: Ba, Sr)

Journal of Alloys and Compounds, Год журнала: 2025, Номер unknown, С. 180939 - 180939

Опубликована: Май 1, 2025

Язык: Английский

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Bmscs-Targeting Piezoelectric Stimulation And Immunomodulatory Dual-Functional Hydrogel for Promoting Diabetic Bone Regeneration

Опубликована: Янв. 1, 2025

Язык: Английский

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Biopiezoelectric-based nanomaterials; a promising strategy in cancer therapy

Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)

Опубликована: Июнь 4, 2025

Язык: Английский

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Bibliometric and Visualized Analysis of Piezoelectric Materials in Biomedical Application

ACS Applied Electronic Materials, Год журнала: 2024, Номер 6(3), С. 1562 - 1573

Опубликована: Фев. 29, 2024

Piezoelectric materials have been extensively utilized in the field of biomedicine. Despite multiple studies reviewing progress biomedical piezoelectric materials, there is still a lack research that provides an objective summary and analysis trends this crucial field. Consequently, study employs range bibliometric methods to comprehensively assess development material-related fields. The number citations critical metric for gauging scientific impact article within its This aims application potential through while providing support future area.

Язык: Английский

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Observation of Ferroelectricity in Carbapenem Intermediates Enables Reactive Oxygen Species Generation by Ultrasound

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(47), С. 32519 - 32528

Опубликована: Ноя. 15, 2024

Organic ferroelectrics show great applications in the fields of biomedicine, including disease treatment, biosensors, and tissue engineering. Organosilicon pharmaceutical intermediates generally include chiral centers have satisfying biosafety, biocompatibility, or even biodegradability, which provide versatile platforms for design ferroelectricity. However, their academic values ferroelectricity long been overlooked. Here, we demonstrated ferroelectric properties 4-acetoxy-azacyclic butanone (4-AA), a key synthetic organosilicon-based intermediate carbapenem drugs. This compound undergoes 222F2-type ferroelectric-ferroelastic phase transition at 326 K. As an organic piezoelectric material, 4-AA can produce reactive oxygen species when subjected to ultrasonic vibrations. Combined with its desirable this material may contribute antimicrobial wound healing, tumor etc. work will inspiration discovery multifunctional biomedical materials as well related application prospects.

Язык: Английский

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