Ultrasonics Sonochemistry, Год журнала: 2024, Номер 107, С. 106928 - 106928
Опубликована: Май 27, 2024
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by infiltration of cells, hyperplasia synovium, and destruction the joint cartilage. Owing to low drug delivery efficiency limited immunosuppression effect, complete cure for RA remains formidable challenge. Here, we show that live macrophages (Mφs) carrying protoporphyrin-loaded Fe
Язык: Английский
BMEMat, Год журнала: 2024, Номер unknown
Опубликована: Март 4, 2024
Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.
Язык: Английский
Процитировано
20
Nano-Micro Letters, Год журнала: 2025, Номер 17(1)
Опубликована: Фев. 24, 2025
Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.
Язык: Английский
Процитировано
4
Materials Today Communications, Год журнала: 2024, Номер 40, С. 109929 - 109929
Опубликована: Июль 23, 2024
Язык: Английский
Процитировано
16
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.
Язык: Английский
Процитировано
16
Small, Год журнала: 2024, Номер 20(44)
Опубликована: Июль 6, 2024
Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.
Язык: Английский
Процитировано
15
Redox Biology, Год журнала: 2025, Номер unknown, С. 103515 - 103515
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Science Advances, Год журнала: 2025, Номер 11(5)
Опубликована: Янв. 29, 2025
Cancer immunotherapies rely on CD8 + cytolytic T lymphocytes (CTLs) in recognition and eradication of tumor cells via antigens presented major histocompatibility complex class I (MHC-I) molecules. However, we observe MHC-I deficiency human murine urologic tumors, posing daunting challenges for successful immunotherapy. We herein report an unprecedented nanosonosensitizer one-dimensional bamboo-like multisegmented manganese dioxide@manganese–bismuth vanadate (BMMBV) to boost multiple branches immune responses targeting MHC-I–deficient tumors. BMMBV markedly augments sonodynamic activity contributed by heteroatoms the lattice bismuth with narrowing bandgaps. Under sonoirradiation, enhances antigen spreading emission adjuvant signals, which potentiate dendritic cell maturation, thereby eliciting high aptitude CTLs. This therapy substantially up-regulates MHC expression cells, are reversely sensitive Alongside, extensive innate complement CTLs eliminating mouse study offers a reinforced strategy against antigen-loss immune-evasive tumor.
Язык: Английский
Процитировано
2
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 9549 - 9574
Опубликована: Сен. 1, 2024
Molecular imaging is an advanced technology that utilizes specific probes or markers in conjunction with cutting-edge techniques to observe and analyze the localization, distribution, activity, interactions of biomolecules within living organisms. Tumor molecular imaging, by enabling visualization quantification characteristics tumor cells, facilitates a deeper more comprehensive understanding tumors, providing valuable insights for early diagnosis, treatment monitoring, cancer biology research. However, image quality still requires improvement, nanotechnology has significantly propelled advancement imaging. Currently, nanoparticle-based technologies encompass radionuclide fluorescence magnetic resonance ultrasound photoacoustic multimodal among others. As our microenvironment deepens, design nanoparticle also evolved, offering new perspectives expanding applications Beyond diagnostics, there marked trend towards integrated diagnosis therapy, image-guided playing pivotal role. This includes surgery, photodynamic chemodynamic therapy. Despite continuous advancements innovative developments many these remain experimental stage require breakthroughs before they can be fully into clinical practice.
Язык: Английский
Процитировано
9
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 2, 2025
Recent insights into covalent organic frameworks (COFs) provide an opportunity for developing new sonosensitizers with the advantages of both small molecules and inorganic nanoagents. Herein, we synthesize two benzotrithiophene-based imine-linked COFs (BTT-DPh-COF BTT-DPy-COF) through density-functional-theory-guided structure editing. The tailored donor-acceptor (D-A) structures optimize band position endow them good intrinsic sonodynamic activity, which can efficiently kill cancer cells, showing excellent therapeutic effect. Particularly, because enhanced D-A effect that promotes charge separation transfer behavior, BTT-DPy-COF exhibits superior ultrasound-triggered reactive oxygen species (ROS) generation capability than BTT-DPh-COF. Therefore, these studies highlight great potential elaborate editing configurations as suitable candidates advanced sonosensitizers.
Язык: Английский
Процитировано
1
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101255 - 101255
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
5